ABSTRACT
Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 microg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.
Subject(s)
Candida/isolation & purification , Candidiasis/microbiology , Cross Infection/microbiology , Hematologic Neoplasms/complications , Immunocompromised Host , Adult , Candidiasis/complications , Candidiasis/epidemiology , Cluster Analysis , Cross Infection/complications , Cross Infection/epidemiology , Disease Outbreaks , Female , Fungemia/microbiology , Humans , Leukemia, Myeloid, Acute/complications , Lymphoma, Follicular/complications , Male , Middle AgedSubject(s)
Food Handling , Hepatitis Antibodies/analysis , Hepatovirus/immunology , Adolescent , Adult , Age Factors , Aged , Female , Hepatitis A/epidemiology , Humans , Immunoenzyme Techniques , Italy/epidemiology , Male , Middle Aged , Prevalence , Risk FactorsABSTRACT
Blastoschizomyces capitatus strains resistant to fluconazole were isolated in three cancer patients. All of the strains had identical genomic DNA restriction profiles. Our findings give evidence for the emergence of fluconazole-resistant B. capitatus and suggest a nosocomial acquisition emanating from a common source within the hospital environment.
Subject(s)
Antifungal Agents/pharmacology , Cross Infection/etiology , Fluconazole/pharmacology , Neoplasms/complications , Trichosporon/isolation & purification , Adult , Aged , Humans , Male , Middle Aged , Trichosporon/drug effectsABSTRACT
The Authors carried out a survey in 25 gyms in the city of Pescara during the period May-July '93 to evaluate their building characteristics, management and organization and to assess microclimate and microbial contamination of the indoor environment. Most of the gyms were not in conformity with the current regulatory issues and because of the lack of basic requirements, e.g. climatisation, the microclimate, expressed as comfort indexes, was by far inadequate. The microbiological findings clearly demonstrated poor hygienic conditions particularly in dressing-rooms and toilets. The Authors, given the inadequacy of most of the gyms examined, point out the need of specific mandatory regulations to assure acceptable levels of indoor climate, hygiene and safety.
