ABSTRACT
We present two middle-aged patients with pruritic, crusted scalp erosions. Skin biopsy showed epidermal acantholysis with IgG and C3 intercellular deposits on direct immunofluorescence, leading to the diagnosis of localized pemphigus vulgaris. Resolution of the lesions without relapse occurred after low doses of oral prednisone and intralesional triamcinolone acetonide.
Subject(s)
Pemphigus , Scalp Dermatoses , Humans , Pemphigus/pathology , Pemphigus/diagnosis , Pemphigus/drug therapy , Scalp Dermatoses/pathology , Scalp Dermatoses/drug therapy , Scalp Dermatoses/diagnosis , Middle Aged , Male , Triamcinolone Acetonide/therapeutic use , Triamcinolone Acetonide/administration & dosage , Female , Prednisone/therapeutic use , Glucocorticoids/therapeutic use , Scalp/pathology , Acantholysis/pathology , Acantholysis/diagnosisABSTRACT
Since the introduction of telaprevir, administered in combination with pegylated interferon and ribavirin for the treatment of patients with chronic hepatitis C, the incidence and severity of skin eruptions have increased significantly. The aim of this prospective study is to assess the frequency of drug-induced skin eruptions and their clinical and histological characteristics in patients who received the above treatment in daily clinical practice at our hospital. A total of 60 patients were included. The frequency of telaprevir-associated skin eruptions was 48.3%, which is slightly below, but close to, previously described ranges. There was a predominance of an eczematous clinical pattern, and spongiotic dermatitis on histological examination. A slightly high frequency of severe skin eruptions (13.3%) was found in our study series, which may be explained by all our patients being assessed and closely monitored by one or more dermatologists.
