ABSTRACT
La Unidad de Oncología e Inmunohematología Pediatricas del Hospital Universitario Miguel Servet (HUMS) de Zaragoza es la única de referencia en la Cornunidad Autónoma de Aragón para el tratamiento integral y seguimiento de los pacientes pediátricos con cáncer y otras enfermedades hematológicas e inmunológicas graves. Asiste, también, a un número importante de pacientes de otras provincias limítrofes con Aragón, como la Rioja y Soria. Las labores asistencial e investigadora de esta Unidad, que se revisaran a continuación, han evolucionado y se han ampliado de forma continua desde su inauguración, hace mas de 30 años (AU)
Hospital Miguel Servet Pediatric Oncology and Immunohematology Unit, is the only reference center in Aragon for the treatment and follow-up of children with cancer and other severe hematological and immunological diseases. It is also responsible for a significant number of patients from nearby regions to Aragon, such as La Rioja and Soria. Its clinical activity and research work, which will be reviewed next, has improved continuously since its opening, over more than 30 years ago (AU)
Subject(s)
Humans , Male , Female , Child , /organization & administration , Hospitals, Pediatric/classification , Transplantation/education , Education, Medical, Continuing , Teaching/ethics , Spain/ethnology , /history , /standards , Hospitals, Pediatric/standards , Transplantation/history , Education, Medical, Continuing/methods , Teaching/methods , Health Services ResearchABSTRACT
Adult acute myeloid leukemia (AML) is a highly heterogeneous stem cell malignancy characterized by the clonal expansion of immature myeloid precursors. AML may emerge de novo, following other hematopoietic malignancies or after cytotoxic therapy for other disorders. Here, we investigated the clonal vs reactive nature of residual maturing bone marrow cells in 59 newly diagnosed adult AML and mixed phenotype acute leukemia (MPAL) patients as assessed by interphase fluorescence in situ hybridization analysis of AML and myelodysplastic syndrome-associated cytogenetic alterations and/or the pattern of chromosome X inactivation, in females. In addition, we investigated the potential association between the degree of molecular/genetic involvement of hematopoiesis and coexistence of altered immunophenotypes by flow cytometry. Our results indicate that residual maturing neutrophils, monocytes and nucleated red cell precursors from the great majority of newly diagnosed AML and MPAL cases show a clonal pattern of involvement of residual maturing hematopoietic cells, in association with a greater number of altered immunophenotypes. These findings are consistent with the replacement of normal/reactive hematopoiesis by clonal myelopoiesis and/or erythropoiesis in most newly diagnosed AML and MPAL cases, supporting the notion that in most adults presenting with de novo AML, accumulation of blast cells could occur over a pre-existing clonal hematopoiesis.
Subject(s)
Bone Marrow/pathology , Hematopoiesis , Leukemia, Biphenotypic, Acute/pathology , Leukemia, Myeloid, Acute/pathology , Adult , Aged , Bone Marrow/immunology , Female , Follow-Up Studies , Humans , Immunophenotyping , In Situ Hybridization, Fluorescence , Karyotyping , Leukemia, Biphenotypic, Acute/genetics , Leukemia, Biphenotypic, Acute/immunology , Leukemia, Myeloid, Acute/genetics , Leukemia, Myeloid, Acute/immunology , Male , Middle Aged , Mutation/genetics , Polymerase Chain Reaction , Prognosis , Proto-Oncogene Proteins c-kit/geneticsABSTRACT
No disponible
Subject(s)
Female , Child , Humans , Sacroiliac Joint , Sarcoma, Ewing/diagnosis , Sarcoma, Ewing/pathology , Seizures, Febrile/etiology , Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Lung Neoplasms/secondary , Follow-Up Studies , Sarcoma, Ewing/drug therapy , Lung Neoplasms/drug therapy , Bone Neoplasms/drug therapyABSTRACT
No disponible
