Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Language
Publication year range
1.
Acta Odontol Scand ; 80(8): 635-640, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35635285

ABSTRACT

OBJECTIVE: Development of a new questionnaire, Oral Health-Related Quality of Life - Neurosensory Disturbances after Orthognathic Surgery (OHRQL-NDO), designed to measure the effects of neurosensory disturbance (NSD) on patients' oral health-related quality of life (OHRQL) and to evaluate reliability and validity of this questionnaire. MATERIALS AND METHODS: A questionnaire including 11 items was constructed. Thirty patients with NSD affecting the lower lip and/or chin following orthognathic surgery were included. Convergent validity was assessed by comparing OHRQL-NDO with OHIP-14 and two global questions. Test-retest reliability was assessed by asking the patients to complete OHRQL-NDO at two different occasions with an interval of two to three weeks. RESULTS: The internal consistency, measured with Cronbach's alpha, was 0.84. The test-retest reliability, measured with ICC, was 0.89 (95% CI 0.77-0.95). The correlation between the mean sum score for the OHRQL-NDO and the mean sum score for the OHIP-14 was r = 0.75, using Pearson correlation coefficient. The correlations between the mean total score for the OHRQL-NDO and the global questions 1 and 2 were r = 0.74 and r = 0.72, respectively. CONCLUSIONS: The current instrument OHRQL-NDO is a promising test, but needs further development to better capture the different aspects of OHRQL. Further tests of the questionnaire must follow in other samples to finalize the instrument.


Subject(s)
Orthognathic Surgery , Quality of Life , Humans , Reproducibility of Results , Pilot Projects , Oral Health , Surveys and Questionnaires , Psychometrics
2.
Bone Rep ; 14: 101089, 2021 Jun.
Article in English | MEDLINE | ID: mdl-34026952

ABSTRACT

Primary chronic osteomyelitis (PCO) of the jaw is a non-infectious, inflammatory state of the jawbone of unknown etiology. In recurrent periods, these patients often exhibit swelling of the cheek, impaired ability to open their mouth as well as pain. Available treatments today include anti-inflammatory or antiresorptive drugs, hyperbaric oxygen, surgical decortication or resection followed by reconstruction where none of them have been described to lead to restored anatomy and complete relief of symptoms. We here report the unexpected complete regression of all clinical symptoms of PCO within three months after initiating pubertal suppression therapy with a gonadotropin-releasing hormone analogue in a 9-year-old girl with PCO of the jaw and early onset of pubertal development. Radiology of the jawbone confirmed complete PCO remission when performed 18 months after starting the hormone suppression therapy. To our knowledge, total regression of PCO in such a short period of time has not been described earlier suggesting an effect of the anti-hormonal therapy per se. In this case report, we discuss possible underlying mechanisms and hypothesize that anti-hormonal treatment could be a potential effective treatment in patients with PCO of the jaw.

3.
Acta Odontol Scand ; 79(1): 19-24, 2021 Jan.
Article in English | MEDLINE | ID: mdl-32432962

ABSTRACT

INTRODUCTION: In orthognathic surgery, understanding the patient's motives for treatment is a key factor for postoperative patient satisfaction and treatment success. In countries/systems where orthognathic surgery is funded by public means, patients are referred mainly due to functional problems, although studies of quality of life related changes after treatment indicate that psychosocial and aesthetic reasons might be equal or more important for the patient. There is no available validated condition specific instruments in the Swedish language for quality of life evaluation of patients with dentofacial deformities. Aims/objectives: Cross cultural translation and adaptation of the English-language instrument 'Orthognathic Quality of Life Questionnaire' (OQLQ) into Swedish. Methods: OQLQ was translated into Swedish. A total of 121 patients in four groups were recruited and the Swedish version of the OQLQ (OQLQ-S) was tested by psychometric methods. Reliability was assessed by internal consistency and test-retest reliability. Validity was evaluated by face, convergent and discriminant validity. Results/findings and conclusions: OQLQ-S is reliable and showed good construct validity and internal consistency and can be used in a Swedish speaking population as a complement to clinical variables to evaluate patients with dentofacial deformity.


Subject(s)
Language , Quality of Life , Esthetics, Dental , Humans , Psychometrics , Reproducibility of Results , Surveys and Questionnaires , Sweden
4.
J Biomed Mater Res A ; 106(4): 997-1007, 2018 04.
Article in English | MEDLINE | ID: mdl-29143443

ABSTRACT

Cortical bone plays a vital role in determining overall bone strength. We investigate the structural, compositional, and nanomechanical properties of cortical bone following ovariectomy (OVX) of 12-week-old Sprague Dawley rats, since this animal model is frequently employed to evaluate the performance of implantable biomaterials in compromised bone healing conditions. Morphological parameters and material properties of bone in the geometrical center of the femoral cortex were investigated four and eight weeks post-OVX and in unoperated controls (Ctrl), using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, Raman spectroscopy, and nanoindentation. The OVX animals showed increase in body weight, diminished bone mineral density, increased intracortical porosity, but increased bone mass through periosteal apposition (e.g., increases in periosteal perimeter, cortical cross-sectional thickness, and cross-sectional area). However, osteocyte densities, osteocyte lacunar dimensions, and the nanomechanical behavior on the single mineralized collagen fibril level remained unaffected. Our correlative multiscale investigation provides structural, chemical, and nanomechanical evidence substantiating earlier reports suggesting that rats ovariectomized at 12 weeks undergo simultaneous bone loss and growth, resulting in the effects of OVX being less obvious. Periosteal apposition contradicts the conventional view of bone loss in osteoporosis but appears advantageous for the greater functional demand imposed on the skeleton by increased body weight and fragility induced by increased intracortical porosity. Through a variety of morphological changes, it is likely that 12-week-old rats are able to adapt to OVX-related microstructural and compositional alterations. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 997-1007, 2018.


Subject(s)
Cortical Bone/pathology , Cortical Bone/physiopathology , Nanoparticles/chemistry , Osteoporosis/pathology , Osteoporosis/physiopathology , Animals , Biomechanical Phenomena , Body Weight , Cell Count , Cortical Bone/diagnostic imaging , Extracellular Matrix/metabolism , Female , Femur/pathology , Femur/physiopathology , Linear Models , Minerals/metabolism , Osteocytes/metabolism , Osteoporosis/diagnostic imaging , Porosity , Rats, Sprague-Dawley , X-Ray Microtomography
5.
Clin Implant Dent Relat Res ; 17 Suppl 2: e679-91, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25916730

ABSTRACT

UNLABELLED: Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonate treatment. PURPOSE: A detailed characterization of sampled peri-necrotic jawbone from bisphosphonate-treated patients was performed at tissue and cellular level (histological analyses and gene expression). MATERIALS AND METHODS: Alveolar bone samples were collected from patients with (n = 5) and without ONJ (n = 5). Healthy patients served as controls (n = 10). RESULTS: The histological analysis demonstrated low to moderate inflammation, displaying areas of inflammatory infiltrate in the bone marrow. Multinuclear giant cells and osteoclasts were found in both groups. Markers of bone formation (alkaline phosphatase, Col1a1, and osteocalcin), bone resorption (receptor activator of NF-kappaB ligand [RANKL], osteoprotegerin [OPG], tartrate-resistant acid phosphatase, and cathepsin K), inflammation (tumor necrosis factor-alpha, interleukin [IL]-1ß, and IL-6), angiogenesis (vascular endothelial growth factor A), and apoptosis (Casp3, Casp8, p53, and Smac) were evaluated. Nonparametric statistical tests were used to identify differences between the groups. In patients with ONJ, the expression level of the proinflammatory marker IL-1ß was strongly up-regulated compared with controls (p = .040). CONCLUSIONS: A down-regulated expression of Casp8 compared with controls was observed (p = .014) in patients treated with bisphosphonates. The RANKL/OPG ratios were similar in the three groups. The results indicate a need to further investigate the molecular mechanisms involved in the course of ONJ related to antiresorptive treatment.


Subject(s)
Bisphosphonate-Associated Osteonecrosis of the Jaw/pathology , Aged , Aged, 80 and over , Alveolar Process/drug effects , Alveolar Process/pathology , Bisphosphonate-Associated Osteonecrosis of the Jaw/metabolism , Case-Control Studies , Female , Gene Expression/drug effects , Gene Expression Profiling , Humans , Male , Middle Aged , Pilot Projects
6.
PLoS One ; 8(12): e84932, 2013.
Article in English | MEDLINE | ID: mdl-24376855

ABSTRACT

The healing of bone defects may be hindered by systemic conditions such as osteoporosis. Calcium phosphates, with or without ion substitutions, may provide advantages for bone augmentation. However, the mechanism of bone formation with these materials is unclear. The aim of this study was to evaluate the healing process in bone defects implanted with hydroxyapatite (HA) or strontium-doped calcium phosphate (SCP) granules, in non-ovariectomised (non-OVX) and ovariectomised (OVX) rats. After 0 (baseline), six and 28d, bone samples were harvested for gene expression analysis, histology and histomorphometry. Tumour necrosis factor-α (TNF-α), at six days, was higher in the HA, in non-OVX and OVX, whereas interleukin-6 (IL-6), at six and 28d, was higher in SCP, but only in non-OVX. Both materials produced a similar expression of the receptor activator of nuclear factor kappa-B ligand (RANKL). Higher expression of osteoclastic markers, calcitonin receptor (CR) and cathepsin K (CatK), were detected in the HA group, irrespective of non-OVX or OVX. The overall bone formation was comparable between HA and SCP, but with topological differences. The bone area was higher in the defect centre of the HA group, mainly in the OVX, and in the defect periphery of the SCP group, in both non-OVX and OVX. It is concluded that HA and SCP granules result in comparable bone formation in trabecular bone defects. As judged by gene expression and histological analyses, the two materials induced different inflammatory and bone remodelling responses. The modulatory effects are associated with differences in the spatial distribution of the newly formed bone.


Subject(s)
Bone Remodeling/physiology , Bony Callus/physiology , Calcium Phosphates/metabolism , Durapatite/metabolism , Fracture Healing/physiology , Strontium/metabolism , Animals , Bone Remodeling/drug effects , Enzyme-Linked Immunosorbent Assay , Female , Gene Expression Profiling , Histological Techniques , Ovariectomy , RANK Ligand/metabolism , Rats , Receptors, Calcitonin/metabolism , Statistics, Nonparametric , X-Ray Diffraction
7.
J Craniomaxillofac Surg ; 41(7): e154-8, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23321050

ABSTRACT

The aim of this cohort study was to evaluate the stability after multi-segmentation of the maxilla for correction of anterior open bite deformities. A total of 33 patients who underwent segmented maxillary osteotomy between 1994 and 2006 were included in the study. Rigid fixation with plates and postsurgical intermaxillary fixation for 6 weeks was applied to each patient. All patients were then followed in a standardized examination procedure at months 6, 12, 18 and up to 30 months postoperatively. Vertical and horizontal relation of the incisors was measured both clinically and on cast models. The main finding was that statistically significant relapse was found vertically, whereas the horizontal relationship to the mandible was unchanged. The vertical relapses were predominantly seen in patients with severe open bite evident preoperatively.


Subject(s)
Maxilla/surgery , Maxillary Osteotomy/methods , Open Bite/surgery , Bone Plates , Cephalometry/methods , Cohort Studies , Facial Asymmetry/surgery , Female , Follow-Up Studies , Humans , Incisor/pathology , Jaw Fixation Techniques , Male , Maxilla/abnormalities , Micrognathism/surgery , Models, Dental , Occlusal Splints , Recurrence , Retrognathia/surgery , Vertical Dimension , Young Adult
8.
Biomaterials ; 34(5): 1546-61, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23182921

ABSTRACT

Bisphosphonates reverse the negative effects of ovariectomy on bone, but they have also been associated with adverse processes in human jawbone. The molecular events determining bone regeneration and implant integration in osteoporotic conditions, with and without bisphosphonate treatment, are unclear. In this study, ovariectomised rats, to which a single dose of saline (NaCl) or zoledronic acid (Zol) was administered, received titanium alloy implants in their tibiae and mandibles. An enzyme-linked immunosorbent assay, gene expression analysis and histomorphometry were performed. The results show that ovariectomy, per se, upregulated the expression of genes denoting bone formation in the tibia, bone remodelling in the mandible and apoptosis in the tibia and mandible. Zoledronic acid administration resulted in lower levels of a remodelling marker in serum and downregulated gene expression for inflammation, bone formation, angiogenesis and apoptosis, mainly in the mandible, after 28 d of healing. Histomorphometry revealed improved bone-to-implant contact in the tibia, while the opposite was observed in the mandible. The present data show that a systemic single dose of zoledronic acid, in ovariectomised animals, results in site-specific differences in the regulation of genes involved in bone healing and regeneration in association with implant installation. These events occur in parallel with site-specific differences in the rate of osseointegration, indicating diverse tissue responses in the tibia and mandible after zoledronic acid treatment. The zoledronic acid effect on gene expression, during the late phase of healing in the mandible, suggests negative effects by the anti-resorptive agent on osseointegration at that particular site.


Subject(s)
Diphosphonates/administration & dosage , Fractures, Bone/therapy , Imidazoles/administration & dosage , Osteitis/prevention & control , Osteogenesis/drug effects , Ovariectomy , Prostheses and Implants , Animals , Bone Density Conservation Agents/administration & dosage , Combined Modality Therapy , Female , Fractures, Bone/metabolism , Fractures, Bone/pathology , Osteitis/metabolism , Osteitis/pathology , Rats , Rats, Sprague-Dawley , Treatment Outcome , Zoledronic Acid
9.
Clin Implant Dent Relat Res ; 11(4): 288-91, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19170719

ABSTRACT

BACKGROUND: Surgery performed under sterile operating conditions, as well as atraumatic surgery, has been stated to be among the most important requirements for successful osseointegration. However, there are few reports concerning the sterile surgical technique in association with implant placement, and the appropriate level of operatory setup is not fully known. PURPOSE: The purpose of this study was to analyze implant survival rate using a simplified surgical operatory setup compared with the use of the original Brånemark System (Nobel Biocare AB, Göteborg, Sweden) protocol. MATERIALS AND METHODS: A total of 1,285 consecutively treated patients were included in the study. Four thousand implants were placed during the period of 1985 to 2003. Group A (using the Brånemark System protocol) comprised of 654 patients and 2,414 implants. Group B (using a simplified operatory setup) comprised of 631 patients and 1,586 implants. Healing was evaluated after 6 months of clinical function. Failure was defined as the removal of implants because of nonosseointegration. Statistic analysis was performed using t-test for paired data. The level of significance was set at 5% for comparison of data. RESULTS: No significant difference with regard to complications and implant survival rate was found in the study. CONCLUSION: The result from the present study suggests that a simplified operatory setup does not affect the survival rate of oral implant treatment.


Subject(s)
Dental Implantation, Endosseous/methods , Dental Implants , Operating Rooms/organization & administration , Adolescent , Adult , Aged , Aged, 80 and over , Clinical Protocols , Dental Implantation, Endosseous/instrumentation , Dental Prosthesis Design , Dental Restoration Failure , Female , Follow-Up Studies , Humans , Male , Middle Aged , Osseointegration/physiology , Protective Clothing , Retrospective Studies , Survival Rate , Wound Healing/physiology , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...