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1.
Atherosclerosis ; 240(2): 351-4, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25875387

ABSTRACT

OBJECTIVE: The MEDCOR trial is a double-blind, randomized study aiming at demonstrating the superiority of molsidomine (direct NO donor) over placebo, used as add-on treatments, on improving endothelial function (EF) after 12 months, in stable angina patients undergoing percutaneous coronary intervention. METHODS: EF was assessed by peripheral vasodilator response (i.e. Endoscore) using arterial tonometry and by several biomarkers, in terms of changes versus baseline after a one-year treatment. RESULTS: The change in Endoscore was +75 ± 130% in placebo group and +39 ± 145% in molsidomine group (p = 0.143). There was a decrease in sICAM-1 with molsidomine (-6%) and an increase with placebo (+6%). The MPO activity/antigen ratio slightly increased with placebo (+9%) and strongly decreased with molsidomine (-42%) (p = 0.020). CONCLUSION: The MEDCOR trial was not able to demonstrate significant differences between molsidomine and placebo for all parameters, except the MPO activity/antigen ratio which significantly decreased with molsidomine (p = 0.020 versus placebo).


Subject(s)
Angina, Stable/therapy , Coronary Artery Disease/therapy , Endothelium, Vascular/drug effects , Molsidomine/therapeutic use , Nitric Oxide Donors/therapeutic use , Percutaneous Coronary Intervention , Vasodilation/drug effects , Vasodilator Agents/therapeutic use , Aged , Angina, Stable/blood , Angina, Stable/diagnosis , Angina, Stable/physiopathology , Belgium , Biomarkers/blood , Combined Modality Therapy , Coronary Artery Disease/blood , Coronary Artery Disease/diagnosis , Coronary Artery Disease/physiopathology , Double-Blind Method , Endothelium, Vascular/metabolism , Endothelium, Vascular/physiopathology , Female , Humans , Intercellular Adhesion Molecule-1/blood , Male , Manometry , Middle Aged , Molsidomine/adverse effects , Nitric Oxide Donors/adverse effects , Percutaneous Coronary Intervention/adverse effects , Peroxidase/blood , Time Factors , Treatment Outcome , Vasodilator Agents/adverse effects
2.
J Cardiovasc Transl Res ; 7(2): 226-31, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24142804

ABSTRACT

The effects of molsidomine (a direct nitric oxide donor) on the endothelial dysfunction have never been evaluated using reactive hyperemia peripheral arterial tonometry (RH-PAT). The objective of the MEDCOR double-blind trial will be to demonstrate the superiority of molsidomine (Coruno® 16 mg, once daily) over placebo, on improving the endothelial function (Endoscore by RH-PAT) after 12 months of treatment in stable angina patients undergoing elective percutaneous coronary intervention (PCI). Study design will take care of the real-life situation, in which patients are being offered PCI and stent placement (drug-eluting or bare metal), but also gold standard medical therapy (beta-blockers, statins, angiotensin-converting enzyme inhibitors (ACEIs), and/or calcium antagonists). Demonstrating clinical and statistical superiority of the study drug over placebo will be a real challenge. Therefore, a sequential approach has been designed with a pilot phase aiming at recruiting 50 patients. Upon evaluation of the results by an independent data steering committee, a larger sample size phase will eventually be considered.


Subject(s)
Angina, Stable/therapy , Coronary Vessels/drug effects , Endothelium, Vascular/drug effects , Molsidomine/therapeutic use , Nitric Oxide Donors/therapeutic use , Percutaneous Coronary Intervention , Research Design , Angina, Stable/diagnosis , Angina, Stable/physiopathology , Belgium , Clinical Protocols , Coronary Vessels/physiopathology , Double-Blind Method , Drug Therapy, Combination , Endothelium, Vascular/physiopathology , Humans , Percutaneous Coronary Intervention/adverse effects , Percutaneous Coronary Intervention/instrumentation , Pilot Projects , Stents , Time Factors , Treatment Outcome
3.
Can Vet J ; 52(4): 394-7, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21731092

ABSTRACT

Porcine circovirus type 2 systemic infection was diagnosed in 2 slaughter-weight pigs based on postmortem examination. The infection was associated with unusual central nervous system lesions characterized by a multifocal lymphohistiocytic to granulomatous meningoencephalomyelitis with giant cell formation. The role of these nervous system lesions in the development of the clinical signs in these pigs remains uncertain.


Subject(s)
Central Nervous System/pathology , Circoviridae Infections/veterinary , Circovirus/isolation & purification , Swine Diseases/pathology , Animals , Circoviridae Infections/diagnosis , Circoviridae Infections/pathology , Fatal Outcome , Immunohistochemistry/veterinary , Polymerase Chain Reaction/veterinary , Swine , Swine Diseases/diagnosis
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