ABSTRACT
INTRODUCTION: Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE: To assess the efficiency of a porous bioresorbable membrane Poly (L-co-DL lactic acid)-co-trimethylene carbonate, PL-co-DLA-co-TMC, as a dermal substitute associated with partial skin graft in rats. METHODS: A 1.5×1.5 cm defect was created on the backs of 40 Wistar rats. The rats were divided into a control group, in which the defects were filled with partial skin graft, and a treated group, in which a membrane associated with the graft was implemented. The animals were sacrificed 7 days or 60 days after the procedure and the results were evaluated by macroscopic and microscopic analysis. RESULTS: The polymer was biocompatible and allowed better regeneration of the dermis with less shrinkage, unlike what occurs in second intention healing. Compared to the control group, the treated group showed a thicker and wider dermis with the presence of skin appendages, suggesting partial graft integration and better healing. The skin graft acted as a biological protection of the wound. CONCLUSION: The study material was shown to act as a biocompatible dermal substitute and promoted less scarring of the dermis. Further studies should be conducted to improve the methodology of the surgical procedure.
ABSTRACT
Aneurysms and thromboses of the portal vein are rare pathologies of the portal system that commonly follow an asymptomatic course. The vast majority of cases are diagnosed as incidental findings during imaging studies. Symptoms of aneurysms are the result of mass effects, while thrombosis symptoms are a function of the liver's ability to form a collateral circulation network in the thrombosis. The scant experience with such cases poses a dilemma for patient management and so the vast majority of authors choose an expectant approach with rigorous patient surveillance and only intervene in symptomatic patients. We report one case of an aneurysm of the portal vein and one case of portal vein thrombosis and discuss management and observation of these patients...
O aneurisma e a trombose de veia porta são doenças raras do sistema porta, que comumente cursam sem sintomas. A grande maioria dos pacientes é diagnosticada com achados em exames de imagem. Os sintomas são atribuídos ao efeito de massa, no caso do aneurisma, e relativos à capacidade hepática de formar uma rede de circulação colateral, no caso da trombose. A escassa experiência nesses casos representa um dilema na abordagem desses pacientes e, portanto, a grande maioria dos autores opta por seguimento rigoroso e a intervenção é indicada apenas para os pacientes sintomáticos. Neste trabalho, relatamos um caso de aneurisma de veia porta e outro de trombose da veia porta, propondo o manejo e o acompanhamento desses pacientes...
Subject(s)
Humans , Male , Adult , Aged , Aortic Aneurysm, Abdominal/surgery , Aortic Aneurysm, Abdominal , Vascular Diseases/diagnosis , Vascular Diseases , Fatty Liver/complications , Venous Thrombosis/surgery , Portal Vein/pathology , Abdomen , Emergency Medical Services/methods , Tomography, X-Ray Computed/methodsABSTRACT
Objetivo: Traçar o perfil epidemiológico das queimaduras químicas do Centro de Tratamento de Queimados do Hospital Regional de Sorocaba (CTQ-Sorocaba). Método: Estudo retrospectivo de levantamento de prontuários de todas as queimaduras químicas atendidas no CTQ-Sorocaba, pelo período de 10 anos (abril de 2001 a março de 2011). Resultados: Observou-se uma relação homem-mulher de 3,71:1. Setenta e cinco por cento dos pacientes eram adultos jovens (de 19 a 45 anos). O hidróxido de sódio e o ácido clorídrico representam quase metade dos casos de queimaduras. A maioria dessas queimaduras foi de 2º grau (41%) e 92% dos casos, de pequenos queimados. O acompanhamento ambulatorial ideal (> 6 meses) foi realizado em apenas 18% dos casos. Mais da metade dos pacientes realizou seguimento inferior a 1 mês. Conclusão: A maior parte das vítimas de queimaduras químicas é do sexo masculino, na faixa etária economicamente ativa, principalmente adultos jovens. Esse dado deve direcionar as campanhas de prevenção, no sentido de reduzir o impacto social e as sequelas geradas por tal afecção.
Purpose: To describe the epidemiology profile of the chemical burns of Burn Treatment Center at the Hospital Regional de Sorocaba (CTQ-Sorocaba). Methods: Retrospective study of medical records of all chemical burns treated at CTQ/Sorocaba, in a 10 years period (April 2001 to March 2011). Results: There was a male to female ratio of 3.71 to 1. Seventy-five percent of the patients were young adults (19 to 45 years-old). Sodium hydroxide and hydrochloric acid represent almost a half of all the burns. Most of these burns were of second degree (41%) and 92% of the cases were small burns. The ideal following (> 6 months) was performed in only 18% of the cases. More than a half of the patients had follow up less than one month. Conclusion: Most victims of chemical burns are male in economically active age group, mainly young adults. This information should target prevention campaigns, to reduce the social impact and consequences generated by this pathology.
