ABSTRACT
We report a case of bilateral lacrimal gland involvement as the first sign of Waldenstrom's macroglobulinaemia in a patient with sarcoidosis. Histological analysis of an incisional biopsy revealed a lymphoplasmocytic lymphoma consistent with Waldenstrom's macroglobulinaemia. No noncaseating granulomas were encountered. Systemic treatment was initiated and resulted in complete resolution of the lesions. In a patient with a systemic disease, such as sarcoidosis, and lacrimal gland involvement, a biopsy of the lacrimal gland mass should be taken to make a correct diagnosis and start appropriate treatment.
Subject(s)
Lacrimal Apparatus Diseases/diagnosis , Lacrimal Apparatus Diseases/therapy , Sarcoidosis/diagnosis , Sarcoidosis/therapy , Waldenstrom Macroglobulinemia/diagnosis , Waldenstrom Macroglobulinemia/therapy , Female , Humans , Lacrimal Apparatus Diseases/etiology , Middle Aged , Sarcoidosis/complications , Waldenstrom Macroglobulinemia/etiologySubject(s)
Brain Diseases/complications , Calcinosis/complications , Epilepsy, Tonic-Clonic/complications , Myoclonus/complications , Adolescent , Adult , Brain Diseases/diagnosis , Calcinosis/diagnosis , Cerebellar Cortex/pathology , Cerebellar Diseases/complications , Electroencephalography , Epilepsy, Tonic-Clonic/diagnosis , Follow-Up Studies , Globus Pallidus/pathology , Humans , Male , Myelin Sheath , Myoclonus/diagnosis , Myoclonus/etiology , Red Nucleus/pathology , Reticular Formation/pathology , Typhoid Fever/complicationsABSTRACT
Serums obtained from patients during acute exacerbations of multiple sclerosis produce a reversible depression of polysynaptic reflex responses when applied to the isolated spinal cord of the frog. Motoneuron discharges initiated by monosynaptic activation through an axosomatic spinal pathway are much less affected than reflex discharges. The active factor in serum appears to depend on the presence of complement.
