ABSTRACT
HLA-DRB4*01:01:12 differs from HLA-DRB4*01:01:01:01 by one nucleotide substitution in codon 175 in exon 3.
Subject(s)
Alleles , Base Sequence , Exons , HLA-DRB4 Chains , Histocompatibility Testing , Sequence Analysis, DNA , Humans , Histocompatibility Testing/methods , Sequence Analysis, DNA/methods , HLA-DRB4 Chains/genetics , Codon , Sequence AlignmentABSTRACT
HLA-DQA1*02:32 differs from DQA1*02:01:01 by one nucleotide substitution in codon 210 in exon 4.
Subject(s)
Alleles , Exons , HLA-DQ alpha-Chains , High-Throughput Nucleotide Sequencing , Histocompatibility Testing , Humans , HLA-DQ alpha-Chains/genetics , High-Throughput Nucleotide Sequencing/methods , Histocompatibility Testing/methods , Base Sequence , Codon , Sequence Analysis, DNA/methodsABSTRACT
HLA-DQA1*01:03:11 differs from HLA-DQA1*01:03:01:02 by one nucleotide substitution in codon 59 in exon 2.
Subject(s)
Nucleotides , Humans , Alleles , HLA-DQ alpha-Chains/genetics , Exons/geneticsABSTRACT
HLA-DRB1*04:04:20 differs from HLA-DRB1*04:04:01:04 by one nucleotide substitution in codon 135 in exon 3.
Subject(s)
Nucleotides , Humans , Alleles , Exons/genetics , HLA-DRB1 Chains/geneticsABSTRACT
HLA-A*32:177 differs from HLA-A*32:01:01:01 by one nucleotide substitution in codon -16 in exon 1.
Subject(s)
HLA-A Antigens , Nucleotides , Humans , Alleles , Exons/genetics , Sequence Analysis, DNA , HLA-A Antigens/geneticsABSTRACT
HLA-DPB1*1516:01 differs from HLA-DPB1*1229:01 by seven nucleotide substitutions in exon 3.
Subject(s)
Base Sequence , Humans , Alleles , HLA-DP beta-Chains/genetics , Exons/geneticsABSTRACT
HLA-DQB1*03:512 differs from DQB1*03:02:01 by one nucleotide substitution in codon 89 in exon 2.
Subject(s)
High-Throughput Nucleotide Sequencing , Humans , Alleles , HLA-DQ beta-Chains/genetics , CodonABSTRACT
HLA-DRB1*14:253 differs from DRB1*14:54:01 by one nucleotide substitution in codon 233 in exon 5.
Subject(s)
High-Throughput Nucleotide Sequencing , Humans , HLA-DRB1 Chains/genetics , Alleles , Codon , Exons/geneticsABSTRACT
HLA-B*14:121 differs from HLA-B*14:01:01:01 by one nucleotide substitution in codon 319 in exon 6.
Subject(s)
Genes, MHC Class I , HLA-B Antigens , Humans , Alleles , Histocompatibility Testing , Codon , HLA-B Antigens/genetics , Sequence Analysis, DNAABSTRACT
HLA-C*05:286 differs from HLA-C*05:01:01:02 by one nucleotide substitution in codon 283 in exon 5.
Subject(s)
Genes, MHC Class I , HLA-C Antigens , Humans , HLA-C Antigens/genetics , Alleles , Histocompatibility Testing , Codon , Sequence Analysis, DNAABSTRACT
HLA-B*51:394Q differs from HLA-B*51:01:01:05 by one nucleotide substitution in codon 339 in exon 7.
Subject(s)
HLA-B Antigens , Humans , Alleles , Histocompatibility Testing , Codon , HLA-B Antigens/genetics , Sequence Analysis, DNAABSTRACT
HLA-C*01:263 differs from HLA-C*01:02:01:01 by one nucleotide substitution in codon 98 in exon 3.
Subject(s)
Genes, MHC Class I , HLA-C Antigens , Humans , HLA-C Antigens/genetics , Alleles , Histocompatibility Testing , Codon , Sequence Analysis, DNAABSTRACT
HLA-B*14:122 differs from HLA-B*14:02:01:01 by one nucleotide substitution in codon 102 in exon 3.
Subject(s)
Genes, MHC Class I , HLA-B Antigens , Humans , Alleles , Histocompatibility Testing , Codon , HLA-B Antigens/genetics , Sequence Analysis, DNAABSTRACT
T-cell mediated rejection (TCMR), de novo anti-HLA donor-specific antibodies (dnDSAs) and ensuing antibody-mediated rejection (ABMR) reduce kidney transplantation (KT) survival. The immunomodulatory effects of 25-hydroxyvitamin D [25(OH)D] could be beneficial for KT outcomes. We aimed to evaluating the association between 25(OH)D levels, the development of dnDSAs, clinical TCMR and ABMR, and graft survival. This single center retrospective study included 253 KT recipients (KTRs) transplanted without preformed DSA between 2010 and 2013. We measured 25(OH)D in successive serum samples: at KT (M0) and M12 for the entire cohort, and additionally at M24 and/or M36 when sera were available. We assessed graft outcomes up to 5 years post-KT. The proportion of KTRs having sufficient 25(OH)D at KT (M0) was high (81.4%) and then dropped at M12 (71.1%). KTRs with sufficient 25(OH)D at M0 experienced less clinical TCMR (HR, 0.41; 95% CI, 0.19-0.88 in multivariate analysis). A sufficient 25(OH)D at M12 was independently associated with a longer dnDSA-free survival (HR, 0.34; 95% CI, 0.17-0.69). There was no association between 25(OH)D and clinical AMBR. Studying the KTRs with 25(OH)D measurements at M12, M24 and M36 (n = 203), we showed that 25(OH)D sufficiency over the 3 first-years post-KT was associated with a longer graft survival in multivariate analyses (HR, 0.39; 95% CI, 0.22-0.70). To our knowledge, this study is the first showing an association between 25(OH)D sufficiency post-KT and dnDSA occurrence in KTRs. Moreover, we reinforce previously published data showing an association between 25(OH)D, TCMR and graft survival in KT.
Subject(s)
Kidney Transplantation , Vitamin D/analogs & derivatives , Humans , Retrospective Studies , Risk Factors , HLA Antigens , Alleles , Antibodies , Graft Rejection , IsoantibodiesABSTRACT
HLA-DRB1*13:03:13 differs from HLA-DRB1*13:03:01:01 by one nucleotide substitution in codon 180 in exon 3.
Subject(s)
HLA-DRB1 Chains , Humans , HLA-DRB1 Chains/genetics , Base Sequence , Alleles , Exons/genetics , CodonABSTRACT
HLA-DRB1*11:324 differs from HLA-DRB1*11:62:02 by one nucleotide substitution in codon 38 in exon 2.
Subject(s)
HLA-DRB1 Chains , Humans , HLA-DRB1 Chains/genetics , Base Sequence , Alleles , Exons/genetics , CodonABSTRACT
HLA-C*06:176:02 differs from HLA-C*06:176:01 by two nucleotide substitutions in codons 236 and 237 in exon 4.
Subject(s)
Genes, MHC Class I , HLA-C Antigens , Humans , HLA-C Antigens/genetics , Alleles , Histocompatibility Testing , Exons/genetics , Sequence Analysis, DNAABSTRACT
HLA-B*51:384 differs from HLA-B*51:01:01:01 by one nucleotide substitution in codon 267 in exon 4.
Subject(s)
HLA-B Antigens , Humans , Alleles , Histocompatibility Testing , Codon , HLA-B Antigens/genetics , Sequence Analysis, DNAABSTRACT
HLA-DRB3*02:192 differs from DRB3*02:02:01:02 by one nucleotide substitution in codon 204 in exon 4.
ABSTRACT
HLA-DPA1*01:159 differs from HLA-DPA1*01:03:01:03 by one nucleotide substitution in codon 120 in exon 3.