Practices of Intellectual Labor in the Republic of Letters: Leibniz and Edward Bernard on Language and European Origins.

For a project on the origins and migrations of the European nations, Leibniz wanted to see a comparative lexicon purporting to derive the Germanic languages from Asiatic sources. Friends in nearby Gotha were known to have the book; its author had corresponded with Leibniz a few years earlier. But actually getting the book was more difficult than one might expect. In addition to the actual logistics and manners of scholarly communication in the late seventeenth century, this essay shows what scholars were trying to accomplish by establishing the prehistoric origins of the modern nations.

Polynesia and polygenism: the scientific use of travel literature in the early 19th century.

Christoph Meiners (1747-1810) was one of 18th-century Europe's most important readers of global travel literature, and he has been credited as a founder of the disciplines of ethnology and anthropology. This article examines a part of his final work, "Untersuchungen über die Verschiedenheiten der Menschennaturen" [Inquiries on the differences of human natures], published posthumously in the 1810s. Here Meiners developed an elaborate argument, based on empirical evidence, that the different races of men emerged indigenously at different times and in different places in natural history. Specifically this article shows how a sedentary scholar who never left Europe constructed a narrative of human origins and migrations on the basis of (1) French theory from the 1750s (Charles de Brosses and Simon Pelloutier) and (2) data gathered by explorers as reported in travel literature (J.R. Forster, Pérouse, Cook, Marsden).

Incidence of thoracic and lumbar spine injuries for restrained occupants in frontal collisions.

The increased utilization of three-point restraint systems has greatly reduced the incidence of spinal injuries in motor vehicle accidents. Nevertheless, several studies which rely upon the National Automotive Sampling System (NASS) have documented lower thoracic and upper lumbar fractures in restrained occupants involved in frontal collisions of moderate severities. Although it has been postulated that the injury mechanism may be related to the occupant being out-of-position or sitting in an unusual posture, conclusions with regard to the precise mechanism of injury are difficult due to the lack of information contained in the NASS database. In addition, previous studies have not reported statistical significance of these injuries. In this study, we combined statistical analysis of frontal collisions in the NASS database with the analysis of data acquired from sled and crash tests, which utilized anthropomorphic test devices (ATDs), in order to evaluate the incidence and potential injury mechanisms underlying thoracic and lumbar spine fractures in moderate frontal impacts. In the first portion of the study, we performed a statistical analysis of the NASS database to estimate the incidence rate of spinal fracture. This was complemented with measurements and analysis of lumbar spine load data derived from frontal sled and crash tests. Analysis of the NASS database demonstrated that thoracolumbar spinal injuries are rare when an occupant is restrained by a lap and shoulder belt, and are often accompanied by abdominal injury. The spinal loads measured during frontal impacts with restrained and nominally positioned ATDs were found to be well below injury thresholds. Our results also suggest that the potential for isolated fracture is increased when the geometry of occupant-to-restraint interaction is compromised, as occurs when an occupant submarines the lap belt.

Modulation effects of epidural spinal cord stimulation on muscle activities during walking.

Epidural spinal cord stimulation (ESCS) combined with partial weight bearing therapy (PWBT) has been reported to facilitate recovery of functional walking for individuals after chronic incomplete spinal cord injury (ISCI). Muscle activities were analyzed in this report to examine the modulation effect of ESCS on muscle recruitment during gait training. Two ISCI individuals participated in the study and both are classified as ASIA C with low motor scores in the lower limbs. Stimulating electrodes were placed at the epidural space over T10-L2 spinal segments, along the midline in participant 1 (S1), and off-midline in participant 2 (S2). Surface electromyograms (EMGs) from leg muscles under both ESCS ON and OFF conditions recorded during treadmill gait were analyzed in time-frequency domains. ESCS application produced acute modulations in muscle activities in both participants, but the observed pattern, magnitude, and spectral content of the EMGs differed. In S1, ESCS induced a significant shift in the temporal pattern of muscle activity toward normal comparing with that when ESCS was OFF, though without eliciting noticeable change in frequency distribution between ESCS ON and OFF conditions. When ESCS was applied in S2, a modulation of EMG magnitude was observed and, consequently, improved joint kinematics during walking. In this case, a stimulation entrainment appeared in time-frequency analysis. The results suggest that ESCS activates neural structures in the dorsal aspect of the spinal cord and facilitates gait-related muscle recruitment. The exact effects of ESCS depend on the electrode placement and possibly injury history and residual functions, but in general ESCS produces a positive effect on improved walking speed, endurance, and reduced sense of effort in both ISCI subjects.

Epidural spinal-cord stimulation facilitates recovery of functional walking following incomplete spinal-cord injury.

We investigated a novel treatment paradigm for developing functional ambulation in wheelchair-dependent individuals with chronic, incomplete spinal-cord injury. By coordinating epidural stimulation of the dorsal structures of the spinal cord with partial weight bearing treadmill therapy, we observed improvement in treadmill and over-ground ambulation in an individual with chronic incomplete tetraplegia. The application of partial weight-bearing therapy alone was not sufficient to achieve functional ambulation over ground, though treadmill ambulation improved significantly. Combining epidural spinal-cord stimulation (ESCS, T10-T12 vertebral levels) with partial weight-bearing therapy resulted in further improvement during treadmill ambulation. Moreover, the combination of therapies facilitated the transfer of the learned gait into over ground ambulation. Performance improvements were elicited by applying continuous, charge-balanced, monophasic pulse trains at a frequency of 40-60 Hz, a pulse duration of 800 micros, and an amplitude determined by the midpoint (50%) between the sensory and motor threshold values. The participant initially reported a reduction in sense of effort for over ground walking from 8/10 to 3/10 (Borg scale), and was able to double his walking speed. After several weeks of over ground training, he reached maximum walking speeds of 0.35 m/s, and was able to ambulate over 325 m. We propose that ESCS facilitated locomotor recovery in this patient by augmenting the use-dependent plasticity created by partial weight bearing therapy. Confirmation of these promising results in a controlled study of groups of spinal-cord-injured subjects is warranted.