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1.
Nutrition ; 61: 143-150, 2019 05.
Article in English | MEDLINE | ID: mdl-30711863

ABSTRACT

OBJECTIVE: The aim of this study was to review the existence and types of correlations between body composition densitometric parameters and laboratory values associated to cardiometabolic risk. METHODS: We retrospectively analyzed data from 316 individuals in the weight range from normality to super-obesity, submitted to total body dual-energy x-ray absorptiometry (DXA) scans and routine biochemistry at S.Orsola-Malpighi Hospital from June 2010 to March 2014. The study included 182 women, 45.8 ± 13.4 y of age, with a body mass index (BMI) of 31.5 (± 11) kg/m2 (group F) and 134 men, 45.4 ± 13.6 y of age, with a BMI of 27.6 (± 7.8) kg/m2 (group M). All patients underwent whole-body scan (Lunar iDXA, GE Healthcare, Madison, WI, USA) and laboratory analysis (blood fasting glucose, total cholesterol, high-density lipoprotein cholesterol, tricylglycerides [TGs], aspartate aminotransferase, and alanine aminotransferase). Correlation between laboratory values and total body and regional fat mass (including visceral adipose tissue [VAT] and subcutaneous adipose tissue in the android region), and lean mass parameters were analyzed with linear and stepwise regressions analysis (significance limit, P < 0.05). Receiver operating characteristic curves were performed to assess the accuracy of the best-fit DXA parameter (VAT) to identify at least one laboratory risk factor. RESULTS: In both groups, BMI and densitometric parameters showed a linear correlation with fasting blood glucose and TG levels and an inverse correlation with high-density lipoprotein cholesterol (P < 0.05), whereas no correlation was observed with total cholesterol levels. The only densitometric parameter retained in the final model of stepwise multiple regression was VAT for fasting blood glucose (group F: ß = 0.4627, P < 0.0001; group M: ß = 0.6221, P < 0.0001) and TG levels (group F: ß = 0.4931, P < 0.0001; group M: ß = 0.1990, P < 0.0261) independently of BMI. The optimal cutoff points of VAT to identify the presence of at least one laboratory risk factor were >1395 g and >1479 cm3 for men and >1281 g and >1357 cm3 for women. CONCLUSIONS: DXA analysis of VAT is associated with selected laboratory parameters used for the evaluation of cardiometabolic risk and could be per se a helpful parameter in the assessment of clinical risk.


Subject(s)
Absorptiometry, Photon/statistics & numerical data , Fasting/blood , Ideal Body Weight , Obesity/physiopathology , Overweight/physiopathology , Adult , Alanine Transaminase , Aspartate Aminotransferases , Blood Glucose/analysis , Body Composition , Body Mass Index , Cardiovascular Diseases/etiology , Cholesterol/blood , Female , Humans , Intra-Abdominal Fat , Lipoproteins/blood , Male , Metabolic Diseases/etiology , Middle Aged , Obesity/complications , Overweight/complications , ROC Curve , Regression Analysis , Retrospective Studies , Risk Assessment , Risk Factors , Subcutaneous Fat
2.
Ann Ital Chir ; 89: 128-137, 2018.
Article in English | MEDLINE | ID: mdl-29848810

ABSTRACT

Hepatocellular carcinoma (HCC) is one of the leading cancer in the world, susceptible to potentially curative liver resection (LR) in selected cases. Centrally located HCC (CL-HCC) are sited in central liver segments and may require complex LR because of their relationship to major vascular and biliary structures and deep parenchymal location. Even though extended segment-oriented resections are recommended for oncological reasons, more conservative LR may be indicated in patients with cirrhosis to preserve an adequate function of the future remnant liver (FRL). To extend the indication to LR and to increase the safety of the surgical procedure, preoperative portal vein embolization (PVE) or sequential transarterial embolization/chemoembolization (TAE/TACE) and PVE have been widely used, to induce atrophy of the embolized segments involved by the tumor and compensatory hypertrophy of the FLR. The most appropriate surgical strategy for small uninodular CL-HCC remains controversial, and should be decided according to the features of the tumor at preoperative imaging, the relationship with major intrahepatic vessels and the expected function of the FRL. We report here two cases of elderly cirrhotic patients with unifocal small CL-HCC, where the surgical strategy was decided according to the kind of relationship of the tumor with the hepatic hilum at preoperative imaging. In the first case there was no clear evidence of neoplastic infiltration of the hilar vessels, so that a minor conservative LR was preferred. In the second patient the tumor was suspected to infiltrate the right portal vein, and a major LR was performed after sequential TACE/PVE. KEY WORDS: Centrally located, Future remnant liver, Hepatocellular carcinoma, Liver cirrhosis, Liver resection, Portal vein embolization, Transarterial chemoembolization.


Subject(s)
Carcinoma, Hepatocellular/surgery , Hepatectomy/methods , Liver Neoplasms/surgery , Liver/surgery , Acute Disease , Aged , Carcinoma, Hepatocellular/diagnostic imaging , Carcinoma, Hepatocellular/etiology , Carcinoma, Hepatocellular/pathology , Fatal Outcome , Female , Hepatitis C, Chronic/complications , Humans , Leukemia , Liver/diagnostic imaging , Liver Cirrhosis/complications , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/etiology , Liver Neoplasms/pathology , Male , Neoplasms, Second Primary , Tomography, X-Ray Computed , Tumor Burden , Ultrasonography
3.
Obes Surg ; 25(3): 443-51, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25218013

ABSTRACT

BACKGROUND: Our aim was to monitor the impact of Roux-en-Y gastric bypass (RYGBP) on body composition over a 24-month period by dual-energy X-ray absorptiometry (DXA). METHODS: Forty-one women (40.6 ± 10.0 years old; 42.6 ± 6.6 kg/m(2)) entering a bariatric surgery programme were submitted to whole-body DXA (Lunar iDXA) before treatment and after 3, 6, 12 and 24 months. Fat mass (FM), non-bone lean mass (LM), bone mineral content (BMC) and density (BMD) were measured at whole body and regionally. Android visceral adipose tissue (VAT) was estimated by a recently validated software. RESULTS: Twenty-nine patients (44.3 ± 11.8 years old; BMI, 45.4 ± 8.9 kg/m(2)) concluded the study. Following surgery, the progressive decrease of BMI was associated with reduced whole-body and regional FM. LM showed a moderate decrease at 3 months and stabilized thereafter. A progressive decrease of total FM/LM and android FM/LM ratios were observed in the 3- to 6-month (-19.1 ± 8.4 % and -26.5 ± 10.9 %, respectively; p < 0.0001) and 6- to 12-month periods (-23.5 ± 16.8 % and -29.4 ± 23.9 %, respectively; p < 0.0001). VAT was the parameter showing the largest decrease (-65.6 ± 17.5 % at 12 months; p < 0.0001). Two years after the surgery, a slight but significant decrease of total and regional LM was observed, without any significant change in BMI. CONCLUSIONS: Body composition significantly changes after RYGBP with a metabolically healthier redistribution of total and regional FM and a positive balance of FM/LM variation. DXA should be considered as a valid supplementary tool for the clinical assessment and follow-up in patients undergoing bariatric surgery.


Subject(s)
Body Composition , Gastric Bypass , Intra-Abdominal Fat/diagnostic imaging , Obesity/surgery , Absorptiometry, Photon , Adult , Bone Density , Female , Follow-Up Studies , Humans , Middle Aged , Young Adult
4.
Obes Surg ; 24(2): 284-91, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24163189

ABSTRACT

BACKGROUND: The optimal dose of low molecular weight heparin (LMWH) to prevent venous thromboembolism (VTE) after bariatric surgery remains controversial. The aim of this multicentre, open-label, pilot study was to evaluate the efficacy and safety of two different doses of the LMWH parnaparin administered to patients undergoing bariatric surgery. METHODS: Patients were randomised to receive 4,250 IU/day (group A) or 6,400 IU/day (group B) of parnaparin s.c. for 7-11 days. Bilateral colour Doppler ultrasound of the lower limb was performed before surgery and at the end of the treatment period. The primary efficacy outcome was a composite of asymptomatic and symptomatic deep vein thrombosis, symptomatic pulmonary embolism and death from any cause during treatment. The primary safety endpoint was major and clinically relevant non-major bleeding. RESULTS: A total of 258 patients underwent randomization; 8 subjects were excluded following the safety analysis. One hundred thirty-one patients [106 females; mean age, 40.3 years (standard deviation (SD) ±9.6); mean body mass index (BMI), 44.6 kg/m(2) (SD ±5.4)] were assigned to group A and 119 patients [93 females; mean age, 41.5 years (SD ±9.9); mean BMI, 44.2 kg/m(2) (SD ±5.4)] were assigned to group B. The rate of the primary efficacy outcome was 1.5% (two cases; 95 % confidence interval (CI), 0.2-6.0%) in group A as compared with 0.8% (one case; 95% CI, 0.4-5.3%) in group B (p = ns). The composite incidence of major bleeding and clinically relevant non-major bleeding was 6.1% (eight cases; 95% CI, 2.9-12.1%) in group A and 5.0% (six cases; 95% CI, 2.1-11.1%) in group B (p = ns). CONCLUSIONS: A parnaparin dose of 4,250 IU/day seems suitable for VTE prevention in patients undergoing bariatric surgery.


Subject(s)
Anticoagulants/administration & dosage , Bariatric Surgery/adverse effects , Heparin, Low-Molecular-Weight/administration & dosage , Obesity, Morbid/surgery , Venous Thromboembolism/prevention & control , Adult , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Humans , Male , Obesity, Morbid/complications , Obesity, Morbid/drug therapy , Pilot Projects , Premedication , Prospective Studies , Treatment Outcome , Venous Thromboembolism/drug therapy
5.
Obes Surg ; 23(1): 131-9, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23129236

ABSTRACT

BACKGROUND: The aims of this study are to evaluate the macroscopic and microscopic changes in the remnant stomach at mid-term follow-up of patients who underwent a Roux-en-Y gastric bypass on vertical banded gastroplasty (RYGB-on-VBG). The stomach could be reached through a 1.1-cm gastro-gastrostomy with an endoscope of standard size. METHODS: From January 2009 to July 2010, 51 asymptomatic patients at 4 and 5 years follow-up after RYGB-on-VBG submitted to upper endoscopy. All of them were examined with standard endoscopy with collection of biopsies in gastric fundus, body, and antrum. The macroscopic and microscopic findings were analyzed according to Sydney Classification. RESULTS: The endoscopy of the remnant stomach was technically easy and already showed on macroscopic examination 90 % cases of gastritis (41.2 % mild, 49 % severe) with tendency of severity in the distal stomach part. Histological analysis detected 39.2 % of active gastritis, 50.6 % of quiescent gastritis, 7.8 % of intestinal metaplasia, and 3.9 % of lymphoma-like gastritis. CONCLUSIONS: The results surprised us. We found a very high rate of mucosa abnormalities after RYGB-on-VBG. All of the patients have to be regularly controlled in follow-up and treatment has to be introduced when needed. Again, we would like to ask the question: what is happening with the remnant stomach after standard RYGB, banded gastric bapass, or minigastric bypass? Did we reach the time to answer the question?


Subject(s)
Biliary Tract/pathology , Gastric Bypass/methods , Gastric Mucosa/pathology , Gastric Stump/pathology , Helicobacter Infections/pathology , Obesity, Morbid/pathology , Obesity, Morbid/surgery , Endoscopy, Gastrointestinal , Female , Gastric Mucosa/microbiology , Gastritis/microbiology , Gastritis/pathology , Helicobacter pylori , Humans , Male , Metaplasia/diagnosis , Middle Aged , Severity of Illness Index , Treatment Outcome , Weight Loss
6.
Surg Obes Relat Dis ; 9(1): 69-75, 2013.
Article in English | MEDLINE | ID: mdl-21978747

ABSTRACT

BACKGROUND: Obesity, well known as a risk factor for several diseases, can also lead to pelvic floor dysfunction (PFD). However, scant data are available regarding PFD in obese individuals. Our study was designed to assess the prevalence, severity, and the quality of life (QOL) effect of PFD in obese women before and after bariatric surgery at a university hospital in Italy. METHODS: A total of 100 obese (body mass index [BMI] ≥30 kg/m(2)) women completed 6 validated specific and QOL questionnaires about PFD. The patients were evaluated by physical examination, endoanal ultrasonography, rectal balloon distension test, and dynamic magnetic resonance imaging. Of the 100 patients, 87 were reassessed 12 months after bariatric surgery. RESULTS: The prevalence of PFD was 81%, and 49% of patients reported that their symptoms adversely affected their QOL. Urinary incontinence (UI) was the most common disorder (61%) and was associated with the BMI (P = .04). Fecal incontinence and pelvic organ prolapse symptoms were reported by 24 and 56 patients, respectively. Urogenital prolapse and rectocele was documented in 15% and 74% of patients, respectively. After a mean BMI reduction of 10 kg/m(2), the prevalence of PFD decreased to 48% (P = .02), with a significant improvement in QOL. The prevalence of UI decreased to 9.2% (P = .0001) and was associated with the decrease in postoperative BMI (P = .04). The rate of resolution of the symptoms was 84%, 85%, and 74% for UI, fecal incontinence, and pelvic organ prolapse, respectively. CONCLUSION: In the present sample of obese women, PFD was common and adversely affected their QOL. A clear association was found between the BMI and UI. Weight loss resulted in improved UI, fecal incontinence, and symptoms of pelvic organ prolapse.


Subject(s)
Gastric Bypass/adverse effects , Obesity/surgery , Pelvic Floor Disorders/etiology , Adult , Fecal Incontinence/etiology , Female , Humans , Middle Aged , Pelvic Organ Prolapse/etiology , Postoperative Complications/etiology , Preoperative Care , Quality of Life , Urinary Incontinence/etiology , Young Adult
7.
J Obes ; 20102010.
Article in English | MEDLINE | ID: mdl-20700409

ABSTRACT

Background. Revision of failed bariatric procedures is a significant challenge for bariatric surgeons, because of the increasing number of recurring morbid obesity or complications, especially in patients with a previous Vertical Banded Gastroplasty (VBG). Methods. Since November 1998, 109 patients with failed or complicated VBG were followed in a retrospective study. 49 patients underwent re-VBG and, since 2004, 60 underwent Roux-en-Y Gastric Bypass-on-Vertical Banded Gastroplasty (RYGB-on-VBG). Results. At 3 years follow-up, mean BMI decreased from 37.4 to 31.2 Kg/m(2) in the first group, and from 35.0 to 28.4 Kg/m(2) in the second. Early complications were 7 (14.3%) in the first group and 4 (6.5%) in the second; late complications were 33 (59.1%) and 11 (18.3%), respectively. Conclusion. Although both operations seem to be effective as bariatric revision procedures in terms of BMI, the mid-term outcomes of RYGB-on-VBG demonstrate the lowest rate of complications and better quality of life.

8.
Surg Obes Relat Dis ; 4(1): 16-25, 2008.
Article in English | MEDLINE | ID: mdl-18069072

ABSTRACT

BACKGROUND: Cancer, perforation, and bleeding in the bypassed stomach after Roux-en-Y gastric bypass (RYGB) are rare, but serious, complications that need an early diagnosis. Our goal was to perform gastric bypass such that traditional endoscopic and radiographic study of the gastric remnant would be possible and, at the same time, obtain results in terms of weight loss equivalent to those found after standard RYGB. A previously published study demonstrated that complete occlusion of the gastrogastric outlet was not necessary to lose weight. We have developed an open RYGB-on-vertical banded gastroplasty procedure. METHODS: Since 2002, 289 patients with a mean age of 40.1 +/- 14.8 years, mean body mass index of 51.4 +/- 7.3 kg/m(2), and mean percentage of excess body weight of 107.3% +/- 36.7% underwent RYGB-on-vertical banded gastroplasty as their primary procedure. RESULTS: The follow-up examinations included radiographic and, if necessary, endoscopic studies at 6 and 12 months postoperatively and annually thereafter. Two cases of anastomotic ulcer were detected, one of which involved band erosion. The percentage of excess weight loss was 48.2% +/- 18.8% after 6 months and 59.0% +/-17.7%, 63.3% +/- 13.9%, 66.9% +/- 17.5%, and 70.0% +/- 17.7% after 1, 2, 3, and 4 years, respectively. The weight loss curve was similar to that for standard RYGB. CONCLUSION: The results of our study have shown that RYGB-on-vertical banded gastroplasty is as effective as traditional RYGB, while allowing for traditional radiography of the bypassed stomach in every patient. Endoscopy of the distal stomach and, therefore, the biliary tract, was also possible. These are the fundamental aspects of the procedure.


Subject(s)
Gastric Bypass/methods , Gastroplasty/methods , Obesity/surgery , Adult , Biliary Tract/diagnostic imaging , Biliary Tract/pathology , Body Mass Index , Endoscopy , Follow-Up Studies , Gastric Stump/diagnostic imaging , Gastric Stump/pathology , Humans , Italy , Middle Aged , Obesity/diagnostic imaging , Obesity/pathology , Radiography , Treatment Outcome , Weight Loss
9.
Obes Surg ; 17(10): 1312-8, 2007 Oct.
Article in English | MEDLINE | ID: mdl-18000728

ABSTRACT

BACKGROUND: Cancer, perforation and bleeding in the bypassed stomach after RYGBP are rare but serious complications that require early diagnosis. Our goal was to perform a Roux-en-Y gastric bypass (RYGBP) whereby the traditional endoscopic and x-ray study of the bypassed stomach was possible, and at the same time obtain a good weight loss, similar to the standard RYGBP. We developed the RYGBP-on-Vertical banded gastroplasty (RYGBP on VBG), where a Goretex band surrounds the gastro-gastric outlet. METHODS: From June 2002 to September 2005, 128 patients, 94 female and 34 male, with age 50.5 +/- 14.8 SD years, BMI 51.6 +/- 7.2 SD kg/m2, and %EW 117.9 +/- 33.5 SD underwent RYGBP on VBG via an open approach. Radiological and, if necessary, endoscopic study has been carried out at 6 months, 1 year and then annually postoperatively. RESULTS: Two cases of anastomotic ulcer were detected, but no case of infection of the prosthetic material was found. Preoperative BMI fell from 51.6 +/- 7.2 to 38.1 +/- 6.6 after 6 months, to 35.0 +/- 7.1 after 1 year, to 34.4 +/- 6.1 after 2 years, and to 33.2 +/- 5.5 after 3 years. CONCLUSION: RYGBP on VBG was effective; the weight loss curve, compared to standard RYGBP, is similar, while allowing the traditional x-ray and endoscopy of the bypassed stomach and thus the biliary tract.


Subject(s)
Biliary Tract Diseases/diagnosis , Endoscopy, Gastrointestinal , Gastric Bypass/methods , Gastroplasty/methods , Postoperative Complications/diagnosis , Stomach Diseases/diagnosis , Adult , Female , Gastric Stump , Humans , Male , Middle Aged , Polytetrafluoroethylene/therapeutic use , Prostheses and Implants , Treatment Outcome
10.
Radiol Med ; 107(5-6): 515-23, 2004.
Article in English, Italian | MEDLINE | ID: mdl-15195014

ABSTRACT

PURPOSE: The aim of the study was to evaluate the role of radiological upper gastroenteric studies to detect early and postoperative complications after gastric restrictive surgery for obesity. MATERIALS AND METHODS: From October 1992 to October 2002, 650 patients submitted to vertical banded gastroplasty (VBG) and Roux-en-Y gastric bypass (RYGBP) underwent radiological follow-up to assess the presence of both early and late postoperative complications. The patients were 546 (84%) women and 104 (16%) men whose average weight was 125 kg (range: 78 to 218 kg). The average female age was 37 years (range: 17 to 69 years) and the average male age 36 (range: 19 to 64 years). Preoperative mean body mass index was 46 kg/m2 (range 31-78 kg/m2). The patients underwent radiological upper gastroenteric investigation employing water soluble contrast material between the 4th and 7th postoperative day. All patients underwent another late examination every year after surgery. RESULTS: At 10 years follow-up in 620 patients submitted to modified Mason VBG we observed the following early postoperative complications: 16 cases (2.6%) of oedema of the stoma, six cases (0.9%) of gastro-oesophageal reflux, one case (0.2%) of staple-line disruption, and one case (0.2%) of intragastric haemorrhage. Late complications in VBG included 26 cases (4.2%) of staple-line disruption, four cases (0.6%) of kinked stomas, six cases (0.9%) of pouch dilatations, two cases (0.4%) of stomal stenosis and one case (0.2%) of gastro-oesophageal reflux. In 30 RYGBP patients we observed the following early postoperative complications: one case (0.8%) of dilated pouch, one case (0.8%) of oedema of the anastomosis and one case (0.8%) of anastomotic leak. Late postoperative complications in the 30 RYGBP patients included three cases (2.5%) of stomal ulcers and one case (0.8%) of gastro-oesophageal reflux. We also examined the annual incidence of complications in late follow-up. DISCUSSION AND CONCLUSIONS: Both early and late radiological studies after gastric bariatric surgery enable the detection of postoperative complications and provided morphological and volumetric data after VBG and RYGBP. Post-operative complications (gastric perforation, stomal stenosis, etc.) need to be emphasised and the clinical approach modified to enable suitable weight loss.


Subject(s)
Gastric Bypass/adverse effects , Gastroplasty/methods , Obesity, Morbid/surgery , Postoperative Complications/diagnostic imaging , Stomach/diagnostic imaging , Stomach/surgery , Adolescent , Adult , Aged , Anastomosis, Roux-en-Y/adverse effects , Female , Follow-Up Studies , Gastroplasty/adverse effects , Humans , Male , Middle Aged , Postoperative Complications/epidemiology , Radiography , Time Factors
11.
Obes Surg ; 13(5): 788-91, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14627479

ABSTRACT

BACKGROUND: Roux-en-Y gastric bypass (RYGBP) is rarely performed in Italy because it involves gastric exclusion. RYGBP with the stomach partitioned by an adjustable gastric band has been previously described. We have developed a functional RYGBP (FRYGBP) where an adjustable band allows access from a stapled gastric bypass pouch into the distal stomach. METHODS: From October 2001 to May 2002, 16 patients underwent FRYGBP. A 30-cc vertical gastric pouch was fashioned by a 25-mm circular and 90-mm four-row stapler as in the Mason VBG. A hand-sewn retrocolic gastroenterostomy with 150-cm Roux and 30-cm afferent limbs completed the operation. The pouch outlet was encircled distal to the gastrojejunostomy by a non-inflated adjustable gastric band. The bands were inflated at 1 month during barium swallow, to demonstrate occlusion of the gastro-gastric outlet and patency of the gastrojejunostomy. RESULTS: There was no operative mortality. After 1 year, mean percent excess BMI loss (%EBMIL) was 71.2 +/- 16.2% (SD), and gastroscopy of the bypassed stomach was possible on 81% of the patients. There were three asymptomatic late complications (19%): two band erosions, converted to RYGBP, and one stenosis of the gastro-gastric outlet. CONCLUSION: FRYGBP thus far has been effective and allows the study of the excluded stomach. This ongoing study will undergo long-term evaluation.


Subject(s)
Gastric Bypass/methods , Stomach Diseases/diagnosis , Stomach Diseases/surgery , Anastomosis, Roux-en-Y , Endoscopy, Gastrointestinal , Female , Humans , Male , Radiography , Stomach Diseases/diagnostic imaging , Treatment Outcome
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