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1.
Invest Radiol ; 58(5): 363-371, 2023 05 01.
Article in English | MEDLINE | ID: mdl-36729753

ABSTRACT

OBJECTIVES: This study aims to evaluate the utility of simultaneous multislice (SMS) acceleration for routine magnetic resonance neurography (MRN) at 3 T. MATERIALS AND METHODS: Patients with multiple sclerosis underwent MRN of the sciatic nerve consisting of a standard fat-saturated T2-weighted turbo spin echo (TSE) sequence using integrated parallel acquisition technique (PAT2) acceleration and 2 T2 TSE sequences using a combination of PAT-SMS acceleration (1) to reduce scan time (PAT2-SMS2; SMS-TSE FAST ) and (2) for time neutral increase of in-plane resolution (PAT1-SMS2; SMS-TSE HR ). Acquisition times were 5:29 minutes for the standard T2 TSE, 3:12 minutes for the SMS-TSE FAST , and 5:24 minutes for the SMS-TSE HR . Six qualitative imaging parameters were analyzed by 2 blinded readers using a 5-point Likert scale and T2 nerve lesions were quantified, respectively. Qualitative and quantitative image parameters were compared, and both interrater and intrarater reproducibility were statistically assessed. In addition, signal-to-noise ratio/contrast-to-noise ratio (CNR) was obtained in healthy controls using the exact same imaging protocol. RESULTS: A total of 15 patients with MS (mean age ± standard deviation, 38.1 ± 11 years) and 10 healthy controls (mean age, 29.1 ± 7 years) were enrolled in this study. CNR analysis was highly reliable (intraclass correlation coefficient, 0.755-0.948) and revealed a significant CNR decrease for the sciatic nerve for both SMS protocols compared with standard T2 TSE (SMS-TSE FAST /SMS-TSE HR , -39%/-55%; P ≤ 0.01). Intrarater and interrater reliability of qualitative image review was good to excellent (κ: 0.672-0.971/0.617-0.883). Compared with the standard T2 TSE sequence, both SMS methods were shown to be superior in reducing pulsatile flow artifacts ( P < 0.01). Ratings for muscle border sharpness, detailed muscle structures, nerve border sharpness, and nerve fascicular structure did not differ significantly between the standard T2 TSE and the SMS-TSE FAST ( P > 0.05) and were significantly better for the SMS-TSE HR than for standard T2 TSE ( P < 0.001). Muscle signal homogeneity was mildly inferior for both SMS-TSE FAST ( P > 0.05) and SMS-TSE HR ( P < 0.001). A significantly higher number of T2 nerve lesions were detected by SMS-TSE HR ( P ≤ 0.01) compared with the standard T2 TSE and SMS-TSE FAST , whereas no significant difference was observed between the standard T2 TSE and SMS-TSE FAST . CONCLUSIONS: Implementation of SMS offers either to substantially reduce acquisition time by over 40% without significantly impeding image quality compared with the standard T2 TSE or to increase in-plane resolution for a high-resolution approach and improved depiction of T2 nerve lesions while keeping acquisition times constant. This addresses the specific needs of MRN by providing different imaging approaches for 2D clinical MRN.


Subject(s)
Multidetector Computed Tomography , Multiple Sclerosis , Sciatic Nerve , Feasibility Studies , Multiple Sclerosis/diagnostic imaging , Sciatic Nerve/diagnostic imaging , Humans , Male , Female , Adult , Middle Aged , Prospective Studies , Case-Control Studies
2.
J Magn Reson Imaging ; 44(3): 745-57, 2016 09.
Article in English | MEDLINE | ID: mdl-26919224

ABSTRACT

PURPOSE: To present a technique, which allows for the in vivo quantification of the spectral line broadening of the human lung in a single breathhold. The line broadening is an interesting parameter of the lung because it can provide information about important lung properties, namely: inflation and oxygen uptake. The proposed technique integrates the asymmetric spin-echo (ASE) approach, which is commonly used to quantify the line broadening, with a single shot turbo spin-echo pulse sequence with half-Fourier acquisition (HASTE), to reduce the acquisition times. MATERIALS AND METHODS: Imaging experiments were performed at 1.5 Tesla on 14 healthy volunteers, using a ASE-prepared HASTE sequence. The line broadening was quantified using a two-points method. Data were acquired at different breathing states: functional residual capacity (FRC) and total lung capacity (TLC), and with different breathing gases: room-air and pure-oxygen. Image acquisition was accomplished within a single breathhold of approximately 15 s duration. The violation of the Carr-Purcell-Meiboom-Gill conditions, deriving from inhomogeneities of the static magnetic field, was overcome by means of radiofrequency-phase cycling and generalized autocalibrating partially parallel acquisitions (GRAPPA) reconstruction. RESULTS: Significant increase of the line broadening was observed with both lung inflation and oxygen concentration (P < 0.0001). Values of the line broadening obtained within the lung parenchyma at different breathing states (1.48 ± 0.29 ppm at FRC and 1.95 ± 0.43 ppm at TLC) are in agreement with previous reports and show excellent reproducibility, with a coefficient of variation <0.03. The mean relative difference observed with oxygen-enhancement was approximately 14%. CONCLUSION: The presented technique offers a robust way to quantify the spectral line broadening of the human lung in vivo. Image acquisition can be accomplished in a single breathhold, which could be suitable for clinical applications on patients with lung diseases. J. Magn. Reson. Imaging 2016;44:745-757.


Subject(s)
Breath Holding , Image Interpretation, Computer-Assisted/methods , Lung/diagnostic imaging , Lung/physiology , Magnetic Resonance Imaging/methods , Respiratory Function Tests/methods , Signal Processing, Computer-Assisted , Adult , Algorithms , Female , Humans , Image Enhancement/methods , Lung/anatomy & histology , Male , Reproducibility of Results , Sensitivity and Specificity , Young Adult
3.
Quant Imaging Med Surg ; 5(6): 799-805, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26807361

ABSTRACT

BACKGROUND: In this study, two practical dual-tuned birdcage configurations for quantitative assessment of articular cartilage with sodium magnetic resonance imaging (MRI) were designed and compared. METHODS: Two 1.5 T dual-tuned birdcages, a four-ring birdcage (FRB) and an alternating rungs birdcage (ARB), were built and then characterized by bench and MRI measurements. The relative uniformity (RU) and the efficiency of the coils were compared using (23)Na and (1)H B1 maps. In vivo images of a volunteer were acquired. RESULTS: Bench measurements showed matching and decoupling coefficients of the quadrature channels lower than -20 dB. The RUs and 180° pulse amplitudes of the FRB/ARB were determined as: (1)H RU =94.4/74.4%, (23)Na RU =95.2/93.6%, (1)H 180° pulse amplitude =69.2/75.4 V and (23)Na 180° pulse amplitude =45.1/45.9 V. The in vivo (23)Na images acquired with the FRB show a signal-to-noise ratio (SNR) of 6 to 14 in the cartilage. CONCLUSIONS: Due to its superior (1)H homogeneity and efficiency and its slightly better (23)Na homogeneity, the FRB is the overall preferred coil for the given requirements of this study. The achieved in vivo SNR is adequate for quantitative (23)Na and high resolution (1)H imaging.

4.
J Magn Reson Imaging ; 41(5): 1454-64, 2015 May.
Article in English | MEDLINE | ID: mdl-24943462

ABSTRACT

PURPOSE: To present a technique for non-contrast-enhanced in vivo imaging of the blood volume fraction of the human lung. The technique is based on the intravoxel incoherent motion (IVIM) approach. However, a substantial novelty is introduced here: the need for external diffusion sensitizing gradients is eliminated by exploiting the internal magnetic field gradients typical of the lung tissue, due to magnetic susceptibility differences at air/tissue interfaces. MATERIALS AND METHODS: A single shot turbo spin-echo sequence with stimulated-echo preparation and electrocardiograph synchronization was used for acquisition. Two images were acquired in a single breath-hold of 10 seconds duration: one reference image and one blood-suppressed image. The blood volume fraction was quantified using a two-compartment signal decay model, as given by the IVIM theory. Experiments were performed at 1.5T in eight healthy volunteers. RESULTS: Values of the blood volume fraction obtained within the lung parenchyma (36 ± 16%) are in good agreement with previous reports, obtained using contrast-enhanced magnetic resonance angiography (33%), and show relatively good reproducibility. CONCLUSION: The presented technique offers a robust way to quantify the blood volume fraction of the human lung parenchyma without using contrast agents. Image acquisition can be accomplished in a single breath-hold and could be suitable for clinical applications on patients with lung diseases. J. Magn. Reson. Imaging 2015;41:1454-1464. © 2014 Wiley Periodicals, Inc.


Subject(s)
Blood Volume Determination/methods , Blood Volume/physiology , Image Interpretation, Computer-Assisted/methods , Lung/physiology , Magnetic Resonance Angiography/methods , Pulmonary Circulation/physiology , Adult , Female , Humans , Imaging, Three-Dimensional/methods , Male , Motion , Reproducibility of Results , Sensitivity and Specificity
5.
PLoS One ; 8(3): e57982, 2013.
Article in English | MEDLINE | ID: mdl-23472127

ABSTRACT

Knowledge of the transmission field (B1(+)) of radio-frequency coils is crucial for high field (B0  = 3.0 T) and ultrahigh field (B0 ≥7.0 T) magnetic resonance applications to overcome constraints dictated by electrodynamics in the short wavelength regime with the ultimate goal to improve the image quality. For this purpose B1(+) mapping methods are used, which are commonly magnitude-based. In this study an analysis of five phase-based methods for three-dimensional mapping of the B1(+) field is presented. The five methods are implemented in a 3D gradient-echo technique. Each method makes use of different RF-pulses (composite or off-resonance pulses) to encode the effective intensity of the B1(+) field into the phase of the magnetization. The different RF-pulses result in different trajectories of the magnetization, different use of the transverse magnetization and different sensitivities to B1(+) inhomogeneities and frequency offsets, as demonstrated by numerical simulations. The characterization of the five methods also includes phantom experiments and in vivo studies of the human brain at 3.0 T and at 7.0 T. It is shown how the characteristics of each method affect the quality of the B1(+) maps. Implications for in vivo B1(+) mapping at 3.0 T and 7.0 T are discussed.


Subject(s)
Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methods , Algorithms , Brain/pathology , Brain Mapping/methods , Computer Simulation , Humans , Image Processing, Computer-Assisted/methods , Imaging, Three-Dimensional/methods , Models, Theoretical , Phantoms, Imaging
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