ABSTRACT
The presence of Trypanosoma in Glossina morsitans morsitans induced a decrease in the physiological activity which is expressed in particular by a statistically higher mortality rate of infected flies. A similar effect appears with sublethal doses of deltamethrin either in infected or non infected insects. A cumulative activity of both effects was also observed in infected and treated flies. Sublethal doses of the pyrethroid compound showed a delay in feeding, abortions and larval clampings. Moreover, deltamethrin demonstrated an intravectorial effect against Trypanosoma which can reduce the transmission ability of flies.
Subject(s)
Pyrethrins/pharmacology , Trypanosoma congolense/drug effects , Tsetse Flies/parasitology , Animals , Eating/drug effects , Insect Vectors , Larva/drug effects , Larva/physiology , Nitriles , Reproduction/drug effects , Trypanosoma congolense/physiology , Trypanosomiasis, African/transmission , Tsetse Flies/drug effects , Tsetse Flies/physiologyABSTRACT
In vitro tests, deltamethrin reduced the parasitemic index of Plasmodium falciparum on human red blood corpuscles. In vivo tests, at sublethal doses, deltamethrin limited the development of the sporogonic cycle of Plasmodium yoelii yoelii in Anopheles stephensi. This novel type of antiplasmodic activity involve an intravectorial route and gives an explanation about surprising antimalaria effects observed several months after treatment.
