ABSTRACT
PURPOSE: It is still not clear the role of perilesional biopsy (PL) and the extension of the random biopsy (RB) scheme to be adopted during mpMRI-guided ultrasound fusion biopsy (FB). To evaluate the increase in diagnostic accuracy achieved by PL and different RB schemes over target biopsy (TB). METHODS: We collected prospectively 168 biopsy-naïve patients with positive mpMRI receiving FB and concurrent 24-core RB. The diagnostic yields of the different possible biopsy schemes (TB only; TB + 4 PL cores; TB + 12-core RB; TB + 24-core RB) were compared by the McNemar test. Clinically significant (CS) prostate cancer (PCA) was defined according to the definition of the PROMIS trial. Regression analyses were used to identify independent predictors of the presence of any cancer, csPCA. RESULTS: The detection rate of CS cancers increased to 35%, 45%, and 49% by adding 4 PL cores, 12, and 24 RB cores, respectively (all p < 0.02). Notably, the largest scheme including 3 TB and 24 RB cores identified a small but statistically significant 4% increase in detection rate of CS cancer, as compared with the second largest scheme. TB alone identified only 62% of the CS cancers. Such figure increased to 72% by adding 4 PL cores, and to 91% by adding 14 RB cores. CONCLUSIONS: We found that PL biopsy increased the detection rate of CS cancers as compared with TB alone. However, the combination of those cores missed about 30% of the CS cancers identified with larger RB cores, notably including a considerable 15% of cases located contralaterally to the index tumor.
Subject(s)
Multiparametric Magnetic Resonance Imaging , Prostatic Neoplasms , Male , Humans , Prostatic Neoplasms/diagnostic imaging , Prostatic Neoplasms/pathology , Prostate/diagnostic imaging , Prostate/pathology , Image-Guided Biopsy , Ultrasonography , Magnetic Resonance Imaging , Ultrasonography, InterventionalABSTRACT
Um levantamento parasitológico foi realizado em 165 funcionários de um frigorifíco situado na área da Grande Vitória, Espírito Santo. As amostras foram submetidas a três métodos de exame: sedimentaçäo, Baermann-Moraes e Kato-Katz. Das 165 amostras, 89,62 por cento foram positivas, sendo os helmintos mais frequentes Strongyloides stercoralis (35,15 por cento), Ancilostomideos (35,15 por cento), Trichocephalus trichiurus (19,39 por cento), Ascaris lumbricoides (16,96 por cento) e Schistosoma mansoni (12,12 por cento). Dentre os protozoários Entamoeba histolytica (13,33 por cento), Endolimax nana (11,51 por cento), Giardia lamblia (10,30 por cento) e Sarcocystis hominis (4,24 por cento).
Subject(s)
Humans , Abattoirs , Intestinal Diseases, Parasitic/epidemiology , Parasite Egg Count , Occupational Groups , Ascaris lumbricoides/parasitology , Endolimax/parasitology , Entamoeba histolytica/parasitology , Giardia lamblia/parasitology , Sarcocystis/parasitology , Schistosoma mansoni/parasitology , Strongyloides stercoralis/parasitology , Trichuris/parasitologyABSTRACT
Os autores apresentam a frequência de parasitas intestinais observados na populaçäo da Grande Vitória, Estado do Espírito Santo - Brasil, durante o período de Janeiro de 1975 a Dezembro de 1982. O total de exames parasitológicos realizados foi de 117.590 em pacientes de diferentes condiçöes sócio-econômicas, usando as técnicas de Sedimentaçäo, Willis, Baermann-Moraes e Kato-Katz. Foram positivos 72.178 (61,38%) para uma ou mais espécies de parasito. O Trichocephalus trichiurus foi o parasito mais frequente - 28,21%, seguido pelo Ascaris lumbricoides - 21,41%, Ancilostomídeos - 16,41%, Strongyloides stercorales - 15,34%, Giardia lamblia - 9,51%, Schistosoma mansoni - 6,04%, Entamoeba histolytica - 4,01%, Sarcocystis hominis - 1,55% e Isospora belli - 0,14%.
