Subject(s)
Immunosuppressive Agents/therapeutic use , Kidney Transplantation , Pregnenediones/therapeutic use , Adolescent , Adult , Cell Count , Child , Child, Preschool , Female , Glucocorticoids/therapeutic use , Humans , Lymphocyte Culture Test, Mixed , Male , Postoperative Care , Prednisone/analogs & derivatives , Prednisone/therapeutic use , Pregnenediones/adverse effects , T-Lymphocytes, Cytotoxic/pathologyABSTRACT
A double-blind, double-paired comparison study was performed to evaluate the effects of increasing concentrations of polidocanol in the sclerotherapy of essential telangiectasias of the legs. Polidocanol 0.25%, 0.50%, 0.75%, and 1.0% were compared with regard to clinical effectiveness, safety, and patient acceptance. All dosages were well tolerated by the patients. There were no allergic reactions to polidocanol and no cases of superficial ulceration nor necrosis. Among those whose veins cleared, there was little difference in time to clearing for the four concentrations, which averaged three to four treatment sessions. No statistically significant differences existed among the four dosages with respect to level of improvement, itching, or neovascularization. Polidocanol 0.75% and 1.0%, however, caused more side effects noted by patients and induced more hyperpigmentation than did the lower concentrations. Polidocanol 0.25% yielded the lowest percentage of patients whose veins cleared. The 0.50% solution was the most effective concentration for total overall clearing of the types of vessels treated in this study. From this information it appears that 0.50% polidocanol may be the sclerosing agent of choice.
Subject(s)
Polyethylene Glycols/therapeutic use , Sclerosing Solutions/therapeutic use , Telangiectasis/drug therapy , Adult , Clinical Trials as Topic , Dose-Response Relationship, Drug , Double-Blind Method , Female , Humans , Middle Aged , Polidocanol , Random AllocationABSTRACT
1. The thymic hormone thymopoietin blocks neuromuscular transmission and was proposed (Goldstein, 1974) as a modulator of synaptic conductivity. 2. The cholinergic-induced inactivation of nicotinic receptor reconstituted into asolectin lipid vesicles was studied in the presence and in the absence of thymopentin, a synthetic pentapeptide corresponding to positions 32-36 of thymopoietin. 3. The present data show that thymopentin accelerates desensitization of the nicotinic acetylcholine receptor, supporting the aforementioned physiological role proposed for thymopoietin. 4. They also suggest that the hormone itself and/or a yet unidentified hormine-derived peptide fragment may act as an endogenous ligand for nicotinic acetylcholine receptor desensitization.
Subject(s)
Peptide Fragments/pharmacology , Receptors, Nicotinic/drug effects , Thymopoietins/pharmacology , Thymus Hormones/pharmacology , Animals , Bungarotoxins/metabolism , Carbachol/pharmacology , Electric Fish , In Vitro Techniques , Receptors, Nicotinic/metabolism , ThymopentinABSTRACT
Multiple symmetric lipomatosis is a fascinating disease of uncertain etiology that manifests as massive lipomatous deposits in specific areas of the body. The clinical syndrome and possible pathogenesis are discussed. Classic surgical lipectomy has been the only treatment thus far reported; we report a patient successfully treated with liposuction.
Subject(s)
Adipose Tissue/surgery , Lipomatosis, Multiple Symmetrical/surgery , Lipomatosis/surgery , Female , Humans , Middle Aged , SuctionABSTRACT
A double-blind, double-paired comparison, placebo-controlled study was undertaken to determine the optimal agent for sclerotherapy of spider telangiectasias of the lower extremities. Sodium tetradecyl sulfate 0.5%, polidocanol 0.25%, heparsal, and normal saline control were evaluated in terms of clinical effectiveness and patient acceptance. Although all of the agents, except for the control, were effective, polidocanol was found to have the fewest adverse reactions and afforded the greatest patient comfort.
