Gas chromatographic determination of some chlorothyl phthalimide compounds.

The use of small-bore glass columns packed with low liquid-phase-loaded insert supports has provided the capability for the separation and quantitative determination of a series of chloroethyl phthalimides. Compounds such as N-(2-chlorovinyl) and N-(1,2-DICHLOROETHYL) PHTHALIMIDE HAVE BEEN MEASURED WITH A RELATIVE STANDARD DEVIATION OF NO MORE THAN 1.4%. The N-(1-chloroethyl) phthalimide compound is not stable even in thisinert system, but it can be stabilized by the room temperature preparation of the N-(1-ethoxyethyl) phthalimide derivative. Methods of standards preparation, calibration, and analysis of N-(1,2-dichloroethyl) phthalimide reaction mixtures are presented.