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J Bacteriol ; 205(12): e0032423, 2023 12 19.
Article in English | MEDLINE | ID: mdl-37971230

ABSTRACT

IMPORTANCE: This study is the first example of C. difficile growing with siderophores as the sole iron source and describes the characterization of the ferric hydroxamate uptake ABC transporter (FhuDBGC). This transporter shows specificity to the siderophore ferrichrome. While not required for pathogenesis, this transporter highlights the redundancy in iron acquisition mechanisms that C. difficile uses to compete for iron during an infection.


Subject(s)
Clostridioides difficile , Siderophores , Iron/metabolism , Ferrichrome/metabolism , Clostridioides difficile/metabolism , Clostridioides , Membrane Transport Proteins
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