ABSTRACT
BACKGROUND: Before the coronavirus disease 2019 (COVID-19) vaccine release, polls showed only 50% of Americans had intention to receive the COVID-19 vaccine. The vaccine hesitancy may result from a lack of confidence in vaccine safety and efficacy. More research is needed to identify whether knowledge of vaccine approval processes relates to vaccination intentions. OBJECTIVES: The objectives of this study were to (1) evaluate participants' knowledge regarding COVID-19 and vaccine approval processes, (2) evaluate participants' intentions to receive the COVID-19 vaccine, and (3) compare participants' knowledge assessment results with COVID-19 vaccine intentions. METHODS: A prospective, cross-sectional questionnaire was administered to patients participating in a pharmacist-led chronic disease state management program. The 22-item questionnaire assessed demographic information and evaluated the participant's knowledge and vaccine intentions. Data were analyzed with an a priori alpha value of 0.05. RESULTS: Nearly all participants answered correctly on questions pertaining to COVID-19 infection (n = 92, 93%), COVID-19 symptoms (n = 96, 96%), and the Food and Drug Administration's roles in vaccine approval processes (n = 92, 92%). Participants scored lower on questions involving the differing requirements between clinical trial phases (n = 20, 21%) and vaccine safety in the United States (n = 51, 53%). Most participants (n = 54, 55.1%) did not believe the trials were taking too long to produce a vaccine, but 40.4% of the participants (n = 40) believed the vaccine was approved too quickly. More than half of the participants (n = 55, 56.1%) desired more information on how vaccines get approved in the United States. Participants who scored higher on the knowledge assessment were more likely to have a plan to receive the vaccine (P = 0.008). CONCLUSIONS: The results of this study demonstrate the influence knowledge has on intentions to receive vaccines and may aid health care providers in their attempts to promote vaccinations.
