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1.
Infection ; 48(6): 871-877, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32725598

ABSTRACT

INTRODUCTION: The novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection with Mycoplasma pneumoniae has been described both in adults and pediatrics whereas only two cases of Chlamydia pneumoniae have been reported in a large US study so far. METHODS: In the present report, we describe a series of seven patients where co-infection with C. pneumoniae (n = 5) or M. pneumoniae (n = 2) and SARS-CoV-2 was detected in a large teaching hospital in Rome. RESULTS AND CONCLUSION: An extensive review of the updated literature regarding the co-infection between SARS-CoV-2 and these atypical pathogens is also performed.


Subject(s)
COVID-19/diagnosis , COVID-19/virology , Chlamydial Pneumonia/diagnosis , Chlamydial Pneumonia/microbiology , Coinfection , Pneumonia, Mycoplasma/diagnosis , Pneumonia, Mycoplasma/microbiology , Adult , Aged , Aged, 80 and over , COVID-19/epidemiology , COVID-19/therapy , Chlamydial Pneumonia/epidemiology , Chlamydial Pneumonia/therapy , Comorbidity , Disease Management , Female , Hospitals, Teaching , Humans , Male , Middle Aged , Pneumonia, Mycoplasma/epidemiology , Pneumonia, Mycoplasma/therapy , Retrospective Studies , Rome/epidemiology , Symptom Assessment , Treatment Outcome , Young Adult
2.
Infection ; 38(2): 102-7, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20191397

ABSTRACT

BACKGROUND: The aim of this paper was to enlarge the available knowledge on clinical and etiological aspects of patients affected by spondylodiscitis. PATIENTS AND METHODS: All patients with spondylodiscitis admitted between January 2001 and December 2007 at the 1,300-bed University Hospital "Policlinico Umberto I" of Rome, Italy, were followed. Demographic characteristics, underlying diseases, invasive procedures, imaging studies, isolated microorganisms, treatment, complications, and outcome were recorded. RESULTS: Eighty-one patients of mean age 57.7 +/- 14.7 years with lumbosacral (72.8%), thoracic (14.8%), and cervical tract (12.3%) site of infection were included, of which 38 developed community-acquired (CA) spondylodiscitis and 43 developed hospital-acquired (HA) spondylodiscitis. Underlying disease was present in 49.4% of patients. HA spondylodiscitis was diagnosed earlier (46.8 +/- 49.7 days) than CA spondylodiscitis (65.0 +/- 55.4 days) (P < 0.05). The most frequently isolated microorganisms were Staphylococcus aureus (28 strains, 43.1%), coagulase-negative staphylococci (CNS) (eight strains, 12.3%), Pseudomonas aeruginosa (eight strains, 12.3%), and three methicillin-resistant S. aureus (MRSA) strains were isolated in CA spondylodiscitis. Fungi and yeasts, isolated in six patients, represented 9.2% of all strains but 17.6% when considering only HA spondylodiscitis. Over 85% of patients were managed by conservative treatment alone, and the treatment time depended on clinical and laboratory evidence. Poor outcome was recorded in 12 (14.8%) patients, and was associated with neurological deficit symptoms (relative risk [RR] 2.87; 95% confidence interval [CI] 1.02-8.07; P < 0.05) and the time between diagnosis and the onset of symptoms > or = 60 days (RR 2.65; 95% CI 0.92-7.59; P < 0.05). CONCLUSIONS: Infectious spondylodiscitis affects most frequently the elderly population, who are more exposed to healthcare contacts. Consequently, the infection etiology includes a growing proportion of multi-resistant bacteria and fungi.


Subject(s)
Bacteria/isolation & purification , Bacterial Infections/epidemiology , Discitis/epidemiology , Discitis/microbiology , Fungi/isolation & purification , Mycoses/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Animals , Bacteria/classification , Bacterial Infections/microbiology , Bacterial Infections/pathology , Discitis/pathology , Female , Fungi/classification , Humans , Male , Middle Aged , Mycoses/microbiology , Mycoses/pathology , Prospective Studies , Risk Factors , Rome/epidemiology , Young Adult
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