Alz Memory – um aplicativo móvel para treino de memória em pacientes com Alzheimer / Alz Memory – a mobile app to stimulate memory of Alzheimer’s disease patients / Alz Memory – una aplicación móvil para estimular la memoria de los pacientes con enfermedad de Alzheimer

O Alzheimer é uma demência caracterizada pelo prejuízo cognitivo, que tem como principal característica o declínio da memória no primeiro estágio da doença. Sabe-se que o Alzheimer ainda não possui cura, mas existem tratamentos para retardar o seu avanço, como o treino de memória. Este artigo tem como objetivo apresentar o Alz Memory, um jogo desenvolvido para estimular a memória de pacientes com Alzheimer, com vistas a minimizar os efeitos da doença sobre ela. Para o desenvolvimento do aplicativo foram utilizados: a linguagem HTML5, as folhas de estilo CSS3, o JavaScript, a biblioteca jQuery e o framework PhoneGap. Os resultados da avaliação preliminar de usabilidade realizada permitiram identificar que os aspectos facilidade de uso, tamanho das letras e imagens, funcionalidades do aplicativo, navegação, controle do usuário, cores e motivação para o uso de outras tecnologias, considerados para o desenvolvimento do jogo, são válidos...

The Alzheimer’s disease is a dementia characterized by cognitive decline, whose main characteristic ismemory decline in the first stage of it. It is known that Alzheimer’s does not have a cure, but there are treatments as the memory training to retard the advance of memory loss. This article aims to present the Alz Memory, a game developed for Alzheimer’s patients to memory training in order to minimize the effects of the disease on the memory. To develop the application were used: HTML5 language, style sheet languagein CSS3, JavaScript, JQuery library and PhoneGap framework. The results of the preliminary evaluation of usability have identified aspects as the ease of use, size of letters and images, application functionality, navigation, user control, colors and motivation for the use of other technologies which were considered important to the development of the game are good...

La enfermedad de Alzheimer es una demencia caracterizada por deterioro cognitivo, que tiene como principal característica la disminución de la memoria en su primera etapa. Se sabe que el alzhéimer no tiene cura, pero existen tratamientos para frenar su avance, como el entrenamiento de la memoria. Este artículo tiene como objetivo presentar el Alz Memory, un juego desarrollado para estimular la memoria de los pacientes de Alzheimer, con el fin de minimizar los efectos de la enfermedad sobre aquella. Para el desarrollo dela aplicación fueron utilizados: lenguaje HTML5, hojas de estilo CSS3, JavaScript, biblioteca jQuery y elframework PhoneGap. Los resultados de la evaluación preliminar de usabilidad realizada identificaron que los aspectos facilidad de uso, tamaño de las letras e imágenes, funcionalidad de la aplicación, navegación, control de usuario, colores y motivación para el uso de otras tecnologías, considerados para el desarrollo del juego, son valiosos...

Inter-observer agreement between dermatologists and oncologists in assessing dermatological toxicities in patients with metastatic colorectal cancer treated by cetuximab-based chemotherapies: a pilot comparative study.

The aim of this study was to measure the inter-observer agreement between two teams of three dermatologists and oncologists in labelling and grading the cetuximab-induced dermatological toxicities from 98 photographs performed in a cohort of 15 patients with metastatic colorectal cancer receiving cetuximab-based chemotherapy. Kappa coefficient (κ) assessed inter-observer grading agreement. Both teams defined by the same terms eight of the 13 (62%) toxic effects reported together. Discrepancies concerned the labelling of rash desquamation, hand-foot syndrome and xerosis and the grading (different and often going in the opposite direction) of various toxicities such as paronychia, xerosis, desquamation and hand-foot syndrome (κ value less than 0.40). Acneiform eruption was recognised by both teams, but the grading allocated by oncologists was lower. Our results suggested the need for a real consensus between oncologists and dermatologists for labelling and grading these dermatological toxicities. Better training of oncologists by using a dermatological atlas would improve inter-observer agreement.

Highly sensitive detection of melanoma based on serum proteomic profiling.

PURPOSE: There is no available tumor marker that can detect primary melanoma. Proteomics analysis has been proposed as a novel tool that would lead to the discovery of potential new tumor markers. METHODS: We developed a serum proteomic fingerprinting approach coupled with a classification method to determine whether proteomic profiling could discriminate between melanoma and healthy volunteers. A total of 108 serum samples from 30 early-stage [American Joint Committee on Cancer (AJCC) stage I or II] and 30 advanced-stage (AJCC stage III or IV) melanoma patients and 48 healthy volunteers were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) utilizing protein chip technology and artificial neural networks. RESULTS: In a first step, a multiprotein classifier was built using a training set of 30 pathologically confirmed melanoma and 24 healthy volunteer serum samples, resulting in good classification accuracy for correct diagnosis and stage classification assignment. Subsequently, our multiprotein classifier was tested in an independent validation set of 30 melanoma and 24 non-cancer serum samples patients, maintained in a good diagnostic accuracy of 98.1% (sensitivity 96.7%, specificity 100%), and 100% stage I/II classification assignment. CONCLUSIONS: Although results remain to be confirmed in larger collective patient cohorts, we could demonstrate the usefulness of proteomic profiling as a sensitive and specific assay to detect melanoma, including non-metastatic melanoma, from the serum.

Nonsurgical treatment of an adult with a Class III malocclusion.

This case report describes the orthodontic treatment of a 43-year-old man with Class III malocclusion and crossbite of the maxillary anterior teeth. Treatment options included orthognathic surgery, nonextraction treatment, premolar extractions, and mandibular incisor extraction. The patient opted for nonsurgical treatment that included the extraction of a mandibular central incisor.