ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Atypical Hemolytic Uremic Syndrome/drug therapy , Thrombotic Microangiopathies/physiopathology , Antibodies, Monoclonal, Humanized/therapeutic use , Hematuria/etiology , Proteinuria/etiologySubject(s)
Atypical Hemolytic Uremic Syndrome/complications , Hematoma/etiology , Liver Diseases/etiology , Adult , Antibodies, Monoclonal, Humanized/therapeutic use , Atypical Hemolytic Uremic Syndrome/drug therapy , Atypical Hemolytic Uremic Syndrome/therapy , Combined Modality Therapy , Female , Hematoma/diagnostic imaging , Hemorrhagic Disorders/etiology , Hemorrhagic Disorders/physiopathology , Heparin/adverse effects , Humans , Liver Diseases/diagnostic imaging , Plasma Exchange , Renal Dialysis , Tomography, X-Ray Computed , UltrasonographyABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Atypical Hemolytic Uremic Syndrome/complications , Atypical Hemolytic Uremic Syndrome/diagnosis , Hematoma/complications , Hematoma/diagnosis , Renal Insufficiency/complications , Hypertension/complications , Systemic Inflammatory Response Syndrome/complications , Systemic Inflammatory Response Syndrome/diagnosis , Anemia, Hemolytic/complications , Anemia, Hemolytic/diagnosis , AbdomenABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Gitelman Syndrome/physiopathology , Hyponatremia/physiopathology , Hypokalemia/physiopathology , Sodium-Potassium-Chloride Symporters/physiology , Diagnosis, DifferentialSubject(s)
Gitelman Syndrome/complications , Hyponatremia/etiology , Adult , Female , Gitelman Syndrome/diagnosis , HumansABSTRACT
Cantharidin is a poisonous substance secreted by blister beetles, including the 'Spanish fly'. Historically, cantharidin was used as an aphrodisiac, vesicant and abortifacient. Symptoms of poisoning include gastrointestinal and genitourinary mucosal irritation along with renal dysfunction. We present the case of a reckless 23-year-old soldier who accepted the challenge of eating a beetle (Berberomeloe majalis). Six hours later he was admitted to the emergency room with abdominal pain, dysuria, gross haematuria with clots, hypotension, fever and renal insufficiency. With intravenous fluid therapy, he recovered clinically. Laboratory parameters returned to normal within 1 week.
ABSTRACT
BACKGROUND: Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus (SLE) that can lead to end-stage renal disease. According to the Kidney Disease Outcomes Global Improving clinical Guidelines for Glomerulonephritis, spot urine protein/creatinine (P/C) ratio should be used for monitoring LN. However, some reports write that the random spot urine P/C ratio is unreliable in monitoring proteinuria in SLE glomerulonephritis patients. The aim of this study was to evaluate the agreement of these two assay methods. METHODS: The prospective observational study was performed. Fifty-three paired (total 106) spot and 24-h urine collections were evaluated. STATISTICAL ANALYSIS: SPSS 20.0. RESULTS: Paired samples t-test did not reveal significant differences between the two-paired assay methods (spot P/C ratio versus 24-h proteinuria and 24-h P/C ratio) and a statistically significant correlation was observed between them: Pearson's coefficient of 0.847 (P < 0.001) and 0.863 (P < 0.001), respectively. However, after stratifying by degrees of proteinuria, a poor correlation was found in the range of <500 mg/day and only 26.6% of 24-h P/C ratio was explained by the spot P/C ratio. Adding to this, for proteinuria range between 500 and 1000 mg/day, there was no correlation (Pearson's -0.098; P > 0.05). In fact, only 1% of 24-h measurements could be explained by the spot P/C ratio. CONCLUSIONS: Our study demonstrated a good correlation between 24-h proteinuria and random P/C ratio among patients with LN. However, this correlation was poor for proteinuria under 500 mg/day and did not exist in a range between 500 and 1000 mg/day. This finding is of greater importance because this range is quite common in patients with LN remission. Until further clarification, to the best of our knowledge, we maintain reluctant to completely substitute the 24-h collection by the P/C ratio especially when a renal flare is suspected, or before any change in therapy.
