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1.
Haemophilia ; 10(2): 183-5, 2004 Mar.
Article in English | MEDLINE | ID: mdl-14962209

ABSTRACT

A 5 month-old baby developed non-ceasing intra-peritoneal bleeding after extensive surgical biopsy for an hepatoblastoma. A single recombinant activated factor VII injection following enlarged hepatectomy helped to resolve quickly this life-threatening haemorrhagic syndrome.


Subject(s)
Coagulants/therapeutic use , Factor VIIa/therapeutic use , Hepatoblastoma/surgery , Liver Neoplasms/surgery , Postoperative Hemorrhage/prevention & control , Biopsy/methods , Hemostasis, Surgical , Humans , Infant , Injections , Liver/pathology , Male , Recombinant Proteins , Treatment Outcome
2.
Fundam Clin Pharmacol ; 11(2): 133-7, 1997.
Article in English | MEDLINE | ID: mdl-9107559

ABSTRACT

The pharmacokinetics of nalbuphine (0.3 mg/kg) administered by the rectal route were studied in ten children undergoing general anaesthesia for minor surgery. Blood sampling was carried out for 8 h after rectal administration and plasma drug concentrations were measured by high performance liquid chromatography using electrochemical detection after an optimized solid-phase extraction procedure. The mean time to achieve the maximum plasma concentration (Cmax = 24 +/- 15 ng/mL) was 25 +/- 11 min and the elimination half-life was 2.7 +/- 0.7 h. The coefficients of variation for Cmax and the concentration-time curve (AUC) were 62 and 68%, respectively. Although rectal absorption is considered irregular, the large intersubject variability is also explainable by a variable hepatic bypass for a drug, like nalbuphine, that undergoes extensive first-pass metabolism. No problem of analgesic efficacy or of local tolerance was reported. In conclusion, the rectal route of administration provides a rapid and reliable absorption of nalbuphine.


Subject(s)
Analgesics, Opioid/pharmacokinetics , Anesthesia, General , Nalbuphine/pharmacokinetics , Administration, Rectal , Analgesics, Opioid/administration & dosage , Area Under Curve , Child , Child, Preschool , Female , Humans , Male , Nalbuphine/administration & dosage
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