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Dissection of the signalling mechanisms underlying FcgammaRIIB-mediated apoptosis of mature B-cells.
Biochem Soc Trans
; 32(Pt 6): 973-5, 2004 Dec.
Article
in English
| MEDLINE
| ID: mdl-15506939
ABSTRACT
The low-affinity receptor for IgG, FcgammaRIIB, negatively regulates BCR (B-cell antigen receptor)-mediated proliferative signalling and thus plays an important role in feedback inhibition of the humoral immune response. Whereas crosslinking of BCR on mature B-cells results in proliferation, co-ligation of FcgammaRIIB results in growth arrest and apoptosis. We have now investigated the signals underlying FcgammaRIIB-driven apoptosis and found this to be dependent on disruption of mitochondrial potential (Deltapsi), involve the pro-apoptotic Bcl-2 family members, Bid and Bad, and be caspase-independent.