ABSTRACT
PURPOSE: To evaluate acute and late skin/subcutaneous toxicities and radiation-induced lung fibrosis (RILF) in patients treated with adjuvant radiotherapy (RT) for synchronous bilateral breast cancers (SBBC), after conservative surgery. METHODS/PATIENTS: Twenty-five patients were treated with volumetric-modulated arc therapy (VMAT/RapidArc®) on both breasts, and checked clinically for detecting RT toxicities during and after treatment. A high-resolution computed tomography (HRCT) was performed, for detecting RILF during follow-up. RESULTS: We registered acute Grade-1 skin toxicity in 18 patients (72%), while six patients (24%) experienced Grade-2 toxicity. No breath symptoms were reported during and after RT. Late Grade-1 subcutaneous toxicity and late Grade-2 skin toxicity were registered in four patients (16%) and one patient (4%), respectively, at a mean follow-up of 36 months. Grade-1 RILF was detected in six patients (30%). The median volume of fibrosis area was 6.5 cc (range 1.3-21.5 cc). The partial volumes receiving a specified dose (V20, V30, V40, and V50) in patients who developed lung fibrosis were significantly bigger than who did not (p < 0.01). We showed that the mean volume of the tumour boost of patients who developed fibrosis (77.7 cc) was not significantly different from the other patients (90.8 cc) (p = 0.5). CONCLUSION: The clinical impact of this technique is favourable, and this is the first clinical study showing RILF by HRCT in a setting of SBBC. Further study with larger accrual is mandatory.
Subject(s)
Breast Neoplasms/radiotherapy , Lung/radiation effects , Neoplasms, Multiple Primary/radiotherapy , Radiation Pneumonitis/etiology , Radiotherapy, Intensity-Modulated/adverse effects , Skin/radiation effects , Adult , Aged , Aged, 80 and over , Breast Neoplasms/diagnostic imaging , Feasibility Studies , Female , Humans , Lung/diagnostic imaging , Middle Aged , Neoplasms, Multiple Primary/diagnostic imaging , Organs at Risk/diagnostic imaging , Organs at Risk/radiation effects , Radiation Pneumonitis/diagnostic imaging , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Adjuvant/adverse effects , Retrospective Studies , Tomography, X-Ray Computed/methodsABSTRACT
This paper reviews experience with 12100 Axial Loader (AL) studies of the lumbar spine both in CT and in MRI 18 years after the development of axial loaded CT and MRI. The Axial Loader device is described together with the CT and MR acquisitions. Disc, intersomatic and articular facet changes are described with a breakdown of the classification of abnormalities as elementary or complex dynamic modifications.
Subject(s)
Mutation , Nuclear Proteins/genetics , Alopecia/genetics , Arrhythmias, Cardiac/genetics , Basal Ganglia Diseases , Chromosomes, Human, Pair 2/genetics , Diabetes Mellitus/genetics , Female , Humans , Hypogonadism/genetics , Intellectual Disability/genetics , Italy , Male , Middle Aged , Open Reading Frames , Pedigree , Ubiquitin-Protein Ligase ComplexesABSTRACT
Using routine electrodiagnostic procedures, the authors searched for physiologic evidence of nerve root compromise in patients with chronic mechanical perturbation to the lumbar spine. They examined 37 patients with spondylolisthesis and various degrees of degenerative changes in the lumbar canal. Clinical and neurophysiologic findings were compared with data obtained from 36 healthy persons. The soleus H-reflex appeared to be a sensitive indicator of sensory fiber compromise at the S1 root level, because changes correlated well with the focal sensory signs and preceded clinical and electromyographic signs of motor root involvement. When these occurred, the clinical findings were consistent with a more severe nerve root deficit and with radiographic evidence of neural compression. The greater sensitivity of the soleus H-reflex may be related to the pathophysiologic events that occur at the lesion site.
Subject(s)
H-Reflex/physiology , Lumbar Vertebrae/pathology , Muscle Weakness/etiology , Muscle, Skeletal/physiopathology , Spinal Nerve Roots/injuries , Spondylolisthesis/complications , Adult , Aged , Humans , Low Back Pain/etiology , Low Back Pain/pathology , Low Back Pain/physiopathology , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/physiopathology , Middle Aged , Muscle Weakness/diagnosis , Muscle Weakness/physiopathology , Muscle, Skeletal/innervation , Muscle, Skeletal/pathology , Neural Conduction/physiology , Predictive Value of Tests , Prognosis , Radiography , Spinal Nerve Roots/pathology , Spinal Nerve Roots/physiopathology , Spondylolisthesis/pathology , Spondylolisthesis/physiopathologyABSTRACT
BACKGROUND: Detachment of the posterior part of the lumbar vertebral ring apophysis has been reported by many authors, associated or not with disc prolapse, and has been ascribed to various mechanisms, although the relationship between the two pathologies remains unclear. METHODS: We studied 26 patients (17 males and 9 females; mean age, 34.3 years) suffering from a lumbar disc herniation with nontraumatic detachment of the ring apophysis. Investigations included standard X ray, computed tomography (CT), tridimensional CT, and magnetic resonance imaging. Nineteen patients were operated on by microsurgical discectomy and removal of bone fragments. RESULTS: Clinical and neuroradiologic features of herniated disc associated with detachment of the ring apophysis have been recognized and have led to the definition of posterior retroextramarginal disc herniations. A further classification is suggested, considering two morphological types that imply clinically distinctive features and a different surgical approach. In all operated cases, removal of the bone fragments was necessary and the results were good. CONCLUSIONS: Our observations led us to postulate a common mechanism in the pathogenesis of disc herniation with nontraumatic detachment of the ring apophysis. They should be distinguished from other calcifications of the disc because a proper surgical technique, including removal of apophyseal fragments, is required.
Subject(s)
Intervertebral Disc Displacement/diagnosis , Intervertebral Disc Displacement/therapy , Lumbar Vertebrae , Adult , Female , Humans , Intervertebral Disc Displacement/diagnostic imaging , Intervertebral Disc Displacement/pathology , Magnetic Resonance Imaging , Male , Tomography, X-Ray ComputedABSTRACT
The authors evaluated the possibility of obtaining tridimensional images of the fibrotendinous structures of the carpal tunnel and interpreting their diagnostic meaning starting from high resolution axial images of computerized tomography. In all of the cases proposed 3D-CT allowed for a representation of the tendons of the flexor muscles and the transverse ligament of the carpus (when present) in a complete and totally original manner. Of particular importance is the choice of a correct threshold value in order to obtain diagnostic imaging.
Subject(s)
Carpal Tunnel Syndrome/diagnostic imaging , Tomography, X-Ray Computed , Adult , Carpal Bones/diagnostic imaging , Female , Humans , Male , Median Nerve/diagnostic imaging , Middle Aged , Muscles/diagnostic imaging , Tendons/diagnostic imaging , Tomography, X-Ray Computed/instrumentation , Tomography, X-Ray Computed/methodsABSTRACT
De Quervain's disease constitutes the most frequently occurring stenotic tenosynovitis. The authors have studied which imaging technique allows for the best representation of anatomopathologic modifications. Ultrasound examination appeared to be the most appropriate and advantageous method as it reveals involvement of the sheaths and tendons in the simplest, most complete, and least expensive manner.
Subject(s)
Tenosynovitis/diagnosis , Female , Humans , Magnetic Resonance Imaging , Male , Syndrome , Tendons/diagnostic imaging , Tendons/pathology , Ultrasonography , Wrist , XeroradiographyABSTRACT
The authors report the method used and the results obtained in 42 vertebral needle biopsies with CT scan monitoring. Material sufficient for a positive histological diagnosis was obtained in 67% of the cases. Indications for the use of this method are conditioned by a suitable clinical and instrumental evaluation, and limited to cases where a histological monomorphous lesion or when en bloc resection are predicted. The need to follow precise rules in terms of technique and manual skill is emphasized.
