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1.
MMWR Morb Mortal Wkly Rep ; 63(43): 982-3, 2014 Oct 31.
Article in English | MEDLINE | ID: mdl-25356607

ABSTRACT

On December 13, 2013, MMWR published a report describing three cases of sudden cardiac death associated with Lyme carditis. State public health departments and CDC conducted a follow-up investigation to determine 1) whether carditis was disproportionately common among certain demographic groups of patients diagnosed with Lyme disease, 2) the frequency of death among patients diagnosed with Lyme disease and Lyme carditis, and 3) whether any additional deaths potentially attributable to Lyme carditis could be identified. Lyme disease cases are reported to CDC through the Nationally Notifiable Disease Surveillance System; reporting of clinical features, including Lyme carditis, is optional. For surveillance purposes, Lyme carditis is defined as acute second-degree or third-degree atrioventricular conduction block accompanying a diagnosis of Lyme disease. During 2001-2010, a total of 256,373 Lyme disease case reports were submitted to CDC, of which 174,385 (68%) included clinical information. Among these, 1,876 (1.1%) were identified as cases of Lyme carditis. Median age of patients with Lyme carditis was 43 years (range = 1-99 years); 1,209 (65%) of the patients were male, which is disproportionately larger than the male proportion among patients with other clinical manifestations (p<0.001). Of cases with this information available, 69% were diagnosed during the months of June-August, and 42% patients had an accompanying erythema migrans, a characteristic rash. Relative to patients aged 55-59 years, carditis was more common among men aged 20-39 years, women aged 25-29 years, and persons aged ≥75 years.


Subject(s)
Death, Sudden, Cardiac/etiology , Lyme Disease/complications , Myocarditis/complications , Population Surveillance , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Death, Sudden, Cardiac/epidemiology , Female , Humans , Infant , Infant, Newborn , Lyme Disease/epidemiology , Male , Middle Aged , Myocarditis/epidemiology , Risk Assessment , Risk Factors , Sex Distribution , United States/epidemiology , Young Adult
2.
Clin Infect Dis ; 47(5): 616-23, 2008 Sep 01.
Article in English | MEDLINE | ID: mdl-18637756

ABSTRACT

BACKGROUND: Enteroviruses are shed in human stool and can cause a wide spectrum of illness. They are the leading cause of aseptic meningitis. METHODS: In 2004, the Connecticut Department of Public Health investigated a meningitis cluster among persons returning from a school-organized trip to Mexico. RESULTS: Among 29 travelers (25 teenagers and 4 adult chaperones), 21 became acutely ill. Viral culture and nucleic acid amplification testing of stool (n=27) and cerebrospinal fluid (n=4) specimens identified enteroviral infection in 20 of 28 travelers from whom any specimen was obtained; 4 had echovirus 30 only, 11 had coxsackievirus (CV) A1 only, 4 had both echovirus 30 and CVA1, and 1 had CVA5 only. Illness onset dates were tightly clustered 4 days after a prolonged swim in the Gulf of Mexico. Time spent swimming was significantly associated with the odds of enteroviral infection (univariate odds ratio for each additional hour swimming, 14.3; 95% confidence interval, 1.3-154.3). Headache, fever, vomiting, and nausea occurred more frequently among the echovirus 30-infected travelers than among the uninfected control subjects (P< .05). The most frequent symptoms among travelers infected with only CVA1 identified were nausea and diarrhea (36% each), but neither was significantly associated with CVA1 infection; 5 patients with CVA1 infection were asymptomatic. CONCLUSIONS: We identified multiple enteroviruses among the travelers. Clustered illness onsets suggest point-source exposure, which likely was a sea swim in sewage-contaminated seawater. Novel molecular amplification and sequencing methodologies were required to recognize the rarely identified CVA1, but it is ambiguous whether CVA1 infection caused illness. Travelers should be aware of risks associated with swimming in natural waters when visiting areas where there is limited sewage treatment.


Subject(s)
Coxsackievirus Infections/epidemiology , Disease Outbreaks , Echovirus Infections/epidemiology , Enterovirus B, Human/isolation & purification , Enterovirus/isolation & purification , Meningitis, Viral/epidemiology , Travel , Adolescent , Adult , Cerebrospinal Fluid/virology , Child , Connecticut/epidemiology , Coxsackievirus Infections/virology , Echovirus Infections/virology , Enterovirus/classification , Enterovirus B, Human/classification , Face/virology , Humans , Meningitis, Viral/virology , Mexico/epidemiology , Swimming , Young Adult
3.
Emerg Infect Dis ; 8(10): 1078-82, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12396919

ABSTRACT

On November 19, 2001, a case of inhalational anthrax was identified in a 94-year-old Connecticut woman, who later died. We conducted intensive surveillance for additional anthrax cases, which included collecting data from hospitals, emergency departments, private practitioners, death certificates, postal facilities, veterinarians, and the state medical examiner. No additional cases of anthrax were identified. The absence of additional anthrax cases argued against an intentional environmental release of Bacillus anthracis in Connecticut and suggested that, if the source of anthrax had been cross-contaminated mail, the risk for anthrax in this setting was very low. This surveillance system provides a model that can be adapted for use in similar emergency settings.


Subject(s)
Anthrax/epidemiology , Bioterrorism/statistics & numerical data , Population Surveillance , Absenteeism , Aged , Aged, 80 and over , Anthrax/diagnosis , Connecticut/epidemiology , Coroners and Medical Examiners , Data Collection , Death Certificates , Female , Humans , Influenza, Human/diagnosis , Inhalation Exposure , Occupational Exposure , Postal Service , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/epidemiology , Respiratory Tract Infections/microbiology , Skin Diseases, Bacterial/diagnosis , Skin Diseases, Bacterial/epidemiology , Skin Diseases, Bacterial/microbiology , Veterinarians
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