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1.
Rev Assoc Med Bras (1992) ; 64(2): 148-153, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29641672

ABSTRACT

OBJECTIVE: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. METHOD: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. RESULTS: The mean CIMC measurement in heterozygous ATM was 0.72 ± 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]; p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. CONCLUSION: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations.


Subject(s)
Ataxia Telangiectasia/blood , Cardiovascular Diseases/diagnosis , Carotid Intima-Media Thickness , Heterozygote , Adult , Ataxia Telangiectasia/genetics , Biomarkers/blood , C-Reactive Protein/analysis , Carotid Arteries , Case-Control Studies , Cholesterol, HDL/blood , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Nutritional Status , Parents , Risk Assessment , Risk Factors , Sex Factors
2.
Rev. Assoc. Med. Bras. (1992) ; 64(2): 148-153, Feb. 2018. tab, graf
Article in English | LILACS | ID: biblio-896432

ABSTRACT

Summary Objective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 ± 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]; p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations.


Resumo Objetivo: Avaliar a espessura do complexo médio-intimal da carótida (CMIC) e os biomarcadores do metabolismo lipídico associados ao risco cardiovascular (RC) em pais de pacientes com ataxia-telangiectasia (AT) e verificar associação com gênero. Método: Estudo transversal prospectivo e controlado com 29 ATM heterozigotos e 14 controles saudáveis. Foram realizados exames bioquímicos e a espessura do CMIC por ultrassonografia. Resultados: A média da medida do CMIC nos ATM heterozigotos foi de 0,72± 0,1 mm (mínimo: 0,5 mm e máximo: 1,0 mm). Observou-se elevado percentual de valores acima do percentil 75 em relação ao referencial populacional (16 [76,2%]), sem diferença estatisticamente significante entre o gênero feminino e o masculino (11/15 [73,3%] vs. 5/6 [83,3%]; p=0.550). A comparação entre os ATM heterozigotos e os controles, estratificados por gênero, mostrou que, nos ATM heterozigotos, as mulheres tinham maiores concentrações de HDL-c em comparação aos homens, e valores mais elevados de PCR-us em relação às mulheres controle. Nos ATM heterozigotos, estratificando segundo gênero, a correlação entre HDL-c e PCR-us foi inversamente proporcional e mais forte entre as mulheres, com tendência à significância estatística. Conclusão: Os ATM heterozigotos não diferiram dos controles em relação aos biomarcadores estudados relacionados ao RC. Entretanto, a maioria deles apresentou aumento na espessura do CMIC, preditor independente de morte, risco para infarto do miocárdio e AVC, quando comparado ao referencial para a mesma faixa etária. Esse achado sugere RC nos ATM heterozigotos e aponta para a necessidade de monitoramento da espessura do CMIC e de orientações nutricionais.


Subject(s)
Humans , Male , Female , Adult , Ataxia Telangiectasia/blood , Cardiovascular Diseases/diagnosis , Carotid Intima-Media Thickness , Heterozygote , Parents , C-Reactive Protein/analysis , Ataxia Telangiectasia/genetics , Biomarkers/blood , Carotid Arteries , Case-Control Studies , Sex Factors , Nutritional Status , Cross-Sectional Studies , Risk Factors , Risk Assessment , Cholesterol, HDL/blood , Middle Aged
3.
J Clin Immunol ; 36(7): 725-32, 2016 10.
Article in English | MEDLINE | ID: mdl-27539235

ABSTRACT

The use of HLA-identical hematopoietic stem cell transplantation (HSCT) demonstrates overall survival rates greater than 75 % for T-B-NK+ severe combined immunodeficiency secondary to pathogenic mutation of recombinase activating genes 1 and 2 (RAG1/2). Limited data exist regarding the use of HSCT in patients with hypomorphic RAG variants marked by greater preservation of RAG activity and associated phenotypes such as granulomatous disease in combination with autoimmunity. We describe a 17-year-old with combined immunodeficiency and immune dysregulation characterized by granulomatous lung disease and autoimmunity secondary to compound heterozygous RAG mutations. A myeloablative reduced toxicity HSCT was completed using an unrelated bone marrow donor. With the increasing cases of immune dysregulation being discovered with hypomorphic RAG variants, the use of HSCT may advance to the forefront of treatment. This case serves to discuss indications of HSCT, approaches to preparative therapy, and the potential complications in this growing cohort of patients with immune dysregulation and RAG deficiency.


Subject(s)
Autoimmune Diseases/complications , Autoimmune Diseases/genetics , Granulomatous Disease, Chronic/complications , Hematopoietic Stem Cell Transplantation , Homeodomain Proteins/genetics , Severe Combined Immunodeficiency/complications , Severe Combined Immunodeficiency/therapy , Adolescent , Alleles , Autoimmune Diseases/diagnosis , Biomarkers , Granulomatous Disease, Chronic/diagnosis , Hematopoietic Stem Cell Transplantation/adverse effects , Hematopoietic Stem Cell Transplantation/methods , Humans , Immunoglobulins, Intravenous/therapeutic use , Immunophenotyping , Infections/diagnosis , Infections/etiology , Infections/therapy , Lymphocyte Count , Mutation , Severe Combined Immunodeficiency/diagnosis , T-Lymphocytes/immunology , T-Lymphocytes/metabolism , Transplantation, Homologous , Treatment Outcome
4.
J Clin Immunol ; 34(2): 146-56, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24402618

ABSTRACT

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here we summarize data from the HIGM syndrome Registry of the Latin American Society for Immunodeficiencies (LASID). Of the 58 patients from 51 families reported to the registry with the clinical phenotype of HIGM syndrome, molecular defects were identified in 37 patients thus far. We retrospectively analyzed the clinical, immunological and molecular data from these 37 patients. CD40 ligand (CD40L) deficiency was found in 35 patients from 25 families and activation-induced cytidine deaminase (AID) deficiency in 2 unrelated patients. Five previously unreported mutations were identified in the CD40L gene (CD40LG). Respiratory tract infections, mainly pneumonia, were the most frequent clinical manifestation. Previously undescribed fungal and opportunistic infections were observed in CD40L-deficient patients but not in the two patients with AID deficiency. These include the first cases of pneumonia caused by Mycoplasma pneumoniae, Serratia marcescens or Aspergillus sp. and diarrhea caused by Microsporidium sp. or Isospora belli. Except for four CD40L-deficient patients who died from complications of presumptive central nervous system infections or sepsis, all patients reported in this study are alive. Four CD40L-deficient patients underwent successful bone marrow transplantation. This report characterizes the clinical and genetic spectrum of HIGM syndrome in Latin America and expands the understanding of the genotype and phenotype of this syndrome in tropical areas.


Subject(s)
Hyper-IgM Immunodeficiency Syndrome/epidemiology , CD40 Ligand/deficiency , CD40 Ligand/genetics , Child, Preschool , Comorbidity , Cytidine Deaminase/deficiency , Cytidine Deaminase/genetics , Female , Hispanic or Latino , Humans , Hyper-IgM Immunodeficiency Syndrome/complications , Hyper-IgM Immunodeficiency Syndrome/diagnosis , Hyper-IgM Immunodeficiency Syndrome/therapy , Infant , Infant, Newborn , Infections/diagnosis , Infections/etiology , Lung/pathology , Male , Registries , Retrospective Studies , Tomography, X-Ray Computed , Treatment Outcome
5.
J Clin Immunol ; 32(2): 212-20, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22193914

ABSTRACT

CD40 ligand (CD40L) deficiency or X-linked hyper-IgM syndrome (X-HIGM) is a well-described primary immunodeficiency in which Pneumocystis jiroveci pneumonia is a common clinical feature. We have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 X-HIGM patients from nine unrelated Brazilian families. Among these, we describe the first case of paracoccidioidomycosis (PCM) in X-HIGM. The molecular genetic analysis of CD40L was performed by gene sequencing and evaluation of CD40L protein expression. Nine of these 11 patients (82%) had fungal infections. These included fungal species common to CD40L deficiency (P. jiroveci and Candida albicans) as well as Paracoccidioides brasiliensis. One patient presented with PCM at age 11 years and is now doing well at 18 years of age. Additionally, one patient presented with a simultaneous infection with Klebsiella and Acinetobacter, and one with condyloma caused by human papilloma virus. Molecular analysis revealed four previously described CD40L mutations, two novel missense mutations (c.433 T > G and c.476 G > C) resulting in the absence of CD40L protein expression by activated CD4(+) cells and one novel insertion (c.484_485insAA) within the TNFH domain leading to a frame shift and premature stop codon. These observations demonstrated that the susceptibility to fungal infections in X-HIGM extends beyond those typically associated with X-HIGM (P. jiroveci and C. albicans) and that these patients need to be monitored for those pathogens.


Subject(s)
Hyper-IgM Immunodeficiency Syndrome, Type 1/complications , Hyper-IgM Immunodeficiency Syndrome, Type 1/genetics , Paracoccidioidomycosis/complications , Adolescent , Adult , Age of Onset , Amino Acid Sequence , Base Sequence , Brazil/epidemiology , CD40 Ligand/deficiency , CD40 Ligand/genetics , CD40 Ligand/metabolism , Child , Child, Preschool , Cohort Studies , Humans , Hyper-IgM Immunodeficiency Syndrome, Type 1/diagnosis , Immunoglobulin Isotypes/blood , Immunoglobulin Isotypes/immunology , Incidence , Infant , Lymphocyte Count , Lymphocyte Subsets/immunology , Lymphocyte Subsets/metabolism , Male , Molecular Sequence Data , Mutation , Paracoccidioidomycosis/epidemiology , Paracoccidioidomycosis/pathology , Pedigree , Sequence Alignment , Young Adult
6.
Rev. bras. alergia imunopatol ; 34(2): 59-64, mar.-abr. 2011. ilus
Article in Portuguese | LILACS | ID: lil-597374

ABSTRACT

Objetivo: Descrever um caso de síndrome de Wiskott-Aldrich, enfatizandoa importância do diagnóstico precoce de uma imunodeficiênciarara, para seu tratamento adequado.Descrição do caso: Criança do sexo masculino, que aos seismeses de idade apresentou eczema em face e pescoço. Três mesesapós, evoluiu com piora, sendo internado com infecção secundária doeczema. Aos dez meses foi novamente internado por otite média comsecreção sanguinolenta, sangramento oral e lesões em pele com sufusõeshemorrágicas. Com um ano foi internado pela terceira vez, devidoà diarreia sanguinolenta, evoluindo com sepse. Exames laboratoriaisevidenciaram plaquetopenia e anemia, além de número reduzido delinfócitos T CD4+ e CD8+. A pesquisa para proteína da síndrome deWiskott-Aldrich foi ausente.Discussão: A Síndrome de Wiskott-Aldrich (WAS) é uma imunodeficiênciarara, ligada ao X, com manifestações clínicas característicasque incluem trombocitopenia com plaquetas pequenas, eczema, infecçõesrecorrentes e incidência aumentada de manifestações autoimunese malignidades. O diagnóstico precoce é muito importante para umtratamento adequado. Até o momento, a única terapia curativa é otransplante de células tronco.


Objective: Describe a case of Wiskott-Aldrich syndrome, emphasizingthe importance of early diagnosis of a rare immunodeficiency, for itsappropriate treatment.Case description: Male child, who at six months of age presentedeczema in face and neck. Three months later, progressed to worse,being admitted with secondary infection of the eczema. At ten monthswas again hospitalized due to otitis media with drainage of blood, oralbleeding and skin lesions with hemorrhagic suffusions. With one yearold was hospitalized for the third time, due to bloody diarrhea, evolvingto sepsis. Laboratory tests showed anemia and thrombocytopenia, andreduced number of CD4 and CD8 T lymphocytes. The search for theWiskott-Aldrich syndrome protein was absent.Discussion: The Wiskott-Aldrich Syndrome (WAS) is a rareimmunodeficiency, X-linked, with clinical features that includethrombocytopenia with small platelets, eczema, recurrent infections andincreased incidence of autoimmune manifestations and malignancies.Early diagnosis is very important for appropriate treatment. So far, theonly curative therapy is the transplantation of stem cells.


Subject(s)
Humans , Male , Child , Eczema , Purpura, Thrombocytopenic , Wiskott-Aldrich Syndrome , Wiskott-Aldrich Syndrome Protein , X-Linked Combined Immunodeficiency Diseases , Diagnostic Techniques and Procedures , Methods
7.
Rev. bras. alergia imunopatol ; 32(5): 184-188, set.-out. 2009.
Article in Portuguese | LILACS | ID: lil-544647

ABSTRACT

Objetivo: Revisar as principais características das células Tregulatórias (Tregs) e os estudos de suas funções nas doenças humanas. As Tregs são componentes da tolerância imunológica, e são moduladores essenciais na resposta imune à patógenos, alérgenos, células cancerígenas e antígenos próprios.Método: Levantamento bibliográfico nos bancos de dados PubMed, Medline, LILACS, SCIELO e capítulos de livros, nos últimos 10 anos.Resultados: Neste trabalho são descritas as principais características fenotípicas e funcionais das Tregs, as três hipótesesde mecanismos de ação das Tregs sobre as células T efetoras e estudos de Tregs em diversas doenças humanas.Conclusão: A identificação dos genes relacionados ao FOXP3 e o esclarecimento dos mecanismos de ação das Tregs, poderão melhorar a terapêutica nas doenças com desregulação imune.


Objective: To review the main characteristics of regulatory T cells (Tregs) and the studies of their function in human diseases. Treg cells are members of immune tolerance, and are essentia I modulators of immune response, including down-modulationof immune response to pathogens, allergens, cancer cells and self-antigens.Methods: Searches in MEDLINE, LILACS, SCIELO data base and book chapters, in the last 10 years.Results: This review describes the role of Tregs on immune regulation, the three current hypotheses of Tregs' action mechanisms on effector T cells, and some studies of Tregs in human diseases.Conclusion: The identification of genes related to FOXP3 and a better comprehension of Tregs' action mechanism, could improve the therapy in diseases with immune dysregulation.


Subject(s)
Humans , Autoimmunity , Common Variable Immunodeficiency , Defense Mechanisms , Immunologic Techniques , Immunologic Tests , T-Lymphocytes, Regulatory , Methods , Diagnostic Techniques and Procedures , Virulence
8.
Immunol Lett ; 94(1-2): 43-6, 2004 Jun 15.
Article in English | MEDLINE | ID: mdl-15234534

ABSTRACT

We demonstrate here that neutrophils from chronic granulomatous disease (CGD) patients release larger amounts of interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha) than neutrophils from control subjects. Incremental cytokine production was observed under both basal and stimulated conditions in neutrophils from two CGD (gp 91phox) patients. The basal production of IL-8 was over seven-fold greater in CGD patients. The two samples assayed showed 3- and 10-fold increases in TNF-alpha. Basically, the same magnitude of increment was observed in lypopolysaccharide (LPS) and serum amyloid A protein (SAA)-stimulated cells. We also found that the levels of SAA and IL-8 were higher in the serum of CGD patients than the levels found in the serum of healthy donors. The increased responsiveness of neutrophils from CGD patients may be closely related with a deficiency in the assembly of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase enzyme system, or it may be due to a frequent inflammatory condition in these patients. In the latter case, the increased serum levels of systemic inflammatory factors, among them SAA, would contribute to the sustained accumulation and activation of phagocytes. Whatever the origin, the excessive production of cytokines may lead to inappropriate activation and tissue injury and even to increased susceptibility to invasive microorganisms, impairing the quality life of CGD patients.


Subject(s)
Granulomatous Disease, Chronic/enzymology , Granulomatous Disease, Chronic/immunology , Lipopolysaccharides/pharmacology , Membrane Glycoproteins/deficiency , NADPH Oxidases/deficiency , Neutrophils/immunology , Serum Amyloid A Protein/pharmacology , Adult , Child , Female , Granulomatous Disease, Chronic/genetics , Humans , Interleukin-8/analysis , Interleukin-8/blood , Male , Membrane Glycoproteins/genetics , NADPH Oxidase 2 , NADPH Oxidases/genetics , Neutrophils/chemistry , Neutrophils/drug effects , Tumor Necrosis Factor-alpha/analysis
9.
J Pediatr (Rio J) ; 79(3): 273-6, 2003.
Article in Portuguese | MEDLINE | ID: mdl-14506539

ABSTRACT

OBJECTIVE: To present a case report of a child who developed sepsis by Salmonella enteritidis associated with the diagnosis of primary immunodeficiency. DESCRIPTION: A twenty-one month old boy presenting fever and skin lesions, bilateral pneumonia with pleural effusion and septic shock. Salmonella enteritidis was isolated in blood cultures and pleural fluid. The identification of the bacteria suggested the presence of the MIM syndrome. The diagnosis of IL-12Rbeta1 was confirmed after IL-12 and IFN-gamma levels were measured using patient cells in a culture medium. The results showed absence of IL-12 and the IFN-gamma post stimulation using BCG. COMMENTS: A severe infection by Salmonella enteritidis is strongly suggestive of an immune system dysfunction. Laboratory tests for humoral, cellular and innate immunity were performed. Interleukin 12 receptor beta1 (IL-12 Rbeta1) deficiency was confirmed after specific laboratory evaluation. The use of INF-gamma is recommended in severe cases.


Subject(s)
Bacteremia/etiology , Receptors, Interleukin/deficiency , Salmonella Infections/etiology , Humans , Infant , Male , Receptors, Interleukin-12
10.
Hum Mutat ; 22(1): 43-50, 2003 Jul.
Article in English | MEDLINE | ID: mdl-12815592

ABSTRACT

Mutations in the ATM gene are responsible for the autosomal recessive disorder ataxia-telangiectasia (A-T). Many different mutations have been identified using various techniques, with detection efficiencies ranging from 57 to 85%. In this study, we employed short tandem repeat (STR) haplotypes to enhance mutation identification in 55 unrelated A-T families of Iberian origin (20 Spanish, 17 Brazilian, and 18 Hispanic-American); we were able to identify 95% of the expected mutations. Allelic sizes were standardized based on a reference sample (CEPH 1347-2). Subsequent mutation screening was performed by PTT, SSCP, and DHPLC, and abnormal regions were sequenced. Many STR haplotypes were found within each population and six haplotypes were observed across several of these populations. Single nucleotide polymorphism (SNP) haplotypes further suggested that most of these common mutations are ancestrally related, and not hot spots. However, two mutations (8977C>T and 8264_8268delATAAG) may indeed be recurring mutational events. Common haplotypes were present in 13 of 20 Spanish A-T families (65%), in 11 of 17 Brazilian A-T families (65%), and, in contrast, in only eight of 18 Hispanic-American families (44%). Three mutations were identified that would be missed by conventional screening strategies. In all, 62 different mutations (28 not previously reported) were identified and their associated haplotypes defined, thereby establishing a new database for Iberian A-T families, and extending the spectrum of worldwide ATM mutations.


Subject(s)
Genetic Testing/methods , Haplotypes/genetics , Mutagenesis/genetics , Protein Serine-Threonine Kinases/genetics , Ataxia Telangiectasia/epidemiology , Ataxia Telangiectasia/ethnology , Ataxia Telangiectasia/genetics , Ataxia Telangiectasia Mutated Proteins , Brazil/epidemiology , Cell Cycle Proteins , Costa Rica/epidemiology , DNA-Binding Proteins , Databases, Genetic , Founder Effect , Hispanic or Latino/genetics , Humans , Internet , Phosphatidylinositol 3-Kinases/genetics , Polymorphism, Single Nucleotide/genetics , Portugal/epidemiology , Spain/epidemiology , Tandem Repeat Sequences/genetics , Tumor Suppressor Proteins , United States/epidemiology
11.
J. pediatr. (Rio J.) ; 79(3): 273-276, maio-jun. 2003. ilus
Article in Portuguese | LILACS | ID: lil-347290

ABSTRACT

Objetivo: descrever caso clínico de uma criança que desenvolveu septicemia por Salmonella enteritidis, sendo diagnosticada imunodeficiência primária. Descrição: paciente masculino, de um ano e nove meses, com febre e lesões de pele há 50 dias, internado com lesão perilabialulcerada com secreção purulenta, lesão ulcerada friável em língua, lesões ulcerocrostosas em membros, pneumonia bilateral com derrame pleural e choque séptico, sendo diagnosticado Salmonella enteritidis como agente etiológico. A identificação desta bactéria direcionou a investigação para a síndrome MIM. O diagnóstico de defici-ência do receptor da interleucina-12 (IL-12Rß1) foi confirmado através da dosagem de IL-12 e do interferon (IFN)-y produzido pelas células do paciente em meio de cultura. O resultado demonstrou ausência de produção de IL-12 e do IFN-y, mesmo após estímulo adequado.Comentários: a identificação da Salmonella enteritidis como agente etiológico de septicemia sugere uma disfunção do sistema imunológico. Foi realizada avaliação laboratorial das imunidades humoral, celular e inata. Após avaliação laboratorial direcionada para síndrome MIM, foi confirmada a deficiência do receptor da interleucina-12 (IL-12Rß1). O uso do IFN-y é recomendado nos casos graves, assim como o tratamento de suporte e o aconselhamento genético


Subject(s)
Humans , Male , Infant , Interferons , Interleukins , Salmonella enteritidis , Sepsis
12.
In. Farhat, Calil Kairalla; Carvalho, Eduardo da Silva; Weckx, Lily Yin; Carvalho, Luiza Helena Falleiros R; Succi, Regina Célia de Menezes. Imunizaçöes: fundamentos e prática. Säo Paulo, Atheneu, 2000. p.19-36, tab, graf.
Monography in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-281261
13.
J. pediatr. (Rio J.) ; 74(sup.1): S3-S11, nov.-dez. 1998. ilus
Article in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-234939

ABSTRACT

Objetivo: O objetivo desta revisäo é apresentar de forma simplificada alguns aspectos da açäo do sistema imunológico frente aos microorganismos. Métodos: Foram revistos artigos de literatura, específicos da área, selecionando-se aspectos mais interessantes para o pediatra. Resultados: Descrevemos no artigo a resposta do istema imunológico frente aos diferentes antígenos, assim como as funçöes de células e citocinas nela envolvidas. Tentamos também enfatizar as características peculiares da resposta imune no recém-nascido e na criança. Conclusäo: O conhecimento dos mecanismos pelos quais o sistema imumológico atua é de vital importância para que o pediatra possa entender a defesa contra infecçöes e a imaturidade decorrente da idade.


Subject(s)
Humans , Infant, Newborn , Child , Immunity, Cellular , Antibody Formation/immunology , Infections/immunology , Immunoglobulin A , Immunoglobulin E , Immunoglobulin M
14.
In. Farhat, Calil Kairalla; Carvalho, Eduardo da Silva; Carvalho, Luiza Helena Falleiros Rodrigues; Succi, Regina Célia de Menezes. Infectologia pediátrica. Säo Paulo, Atheneu, 2 ed; 1998. p.3-11, tab.
Monography in Portuguese | LILACS, Sec. Est. Saúde SP | ID: lil-260863
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