Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs / Diagnósticos histomorfológico e imunofenotípico de tumores estromais gastrointestinais e outros sarcomas que acometem o intestino de cães

Abstract In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis.

Resumo Tendo em vista a semelhança morfológica entre tumores estromais gastrointestinais (GIST) e outros sarcomas do intestino de cães, objetivou-se realizar o diagnóstico histomorfológico e imunoistoquímico desses tumores, associando raça, sexo e idade, localização e invasão tumoral. Foram avaliados 217 casos por histopatologia e incluídos 36 diagnosticados por imuno-histoquímica (24 GIST e 12 outros sarcomas intestinais). Cães sem raça definida foram os mais diagnosticados com GIST, principalmente fêmeas idosas (9,5±2,2 anos); nos demais sarcomas intestinais, mestiços e Dachshunds, machos e fêmeas, foram igualmente acometidos. O ceco foi o mais acometido pelos GISTs, com invasão tumoral das camadas intestinais em todos os casos. O intestino delgado foi o mais acometido pelos demais sarcomas intestinais, com invasão das camadas na maioria desses tumores. GISTs expressaram marcadores como CD117 e DOG-1, ao contrário de outros sarcomas intestinais. O GIST e outros sarcomas intestinais denotaram características histomorfológicas e imunofenotípicas semelhantes à histopatologia, justificando a associação da imuno-histoquímica para o diagnóstico definitivo.

Isometry of potential attachment sites for the iliotrochanteric suture in dogs: an ex vivo study

Background: Coxofemoral luxation is the most common traumatic luxation in dogs and the iliotrochanteric suture is one of the surgical treatment options. The orthopedic suture aimed at surgically restoring joint movement should be employed in an isometric manner in order to maintain adequate tension throughout the arc of motion. This study aimed to determine the isometric points for the iliotrochanteric suture in dogs during the joint extension and flexion movements. This evaluation was performed both in the intact hip joint and in the luxation model, establishing the best combination, among the determined points, for the reestablishment of normal joint movement. Materials, Methods & Results: Radiographic analyses of 12 canine cadaveric hips, both intact and in craniodorsal luxation model, were performed in a neutral position, flexion at 50°, and extension at 150°. In the trochanteric segment, two parallel lines were drawn, creating the central vertical axis and the secondary vertical axis. Three points were then determined on each axis, from proximal to distal, corresponding to 25, 50, and 75% of the height of the axis, and were labelled as T1, T2, and T3 and T4, T5, and T6, respectively. In the iliac segment, a line perpendicular to the longitudinal axis of the ilium was drawn, and 25, 50, and 75% of this height corresponded to points I1, I2, and I3, respectively. The lengths between the points were measured, with the objective of evaluating which combination of points presented less variation in the joint positions. The central location of the iliac and trochanteric segments, determined respectively by I2 and T2, provided smaller variations during the maximal movements of hip flexion and extension. Discussion: The surgical techniques of iliotrochanteric suture target to maintain the internal rotation of the femoral head inside the acetabulum and abduction of the femur until...

Parafimose traumática: relato em cão

A parafimose, uma das diferentes afecções que podem atingir o sistema reprodutor masculino, é uma condição caracteriza da pela incapacidade do pênis em se retrair corretamente, que atinge cães machos de diferentes raças e idades. A gravidade é variável, podendo acarretar desde problemas reprodutivos a óbito. O objetivo do presente relato é descrever um caso de parafimose em um paciente canino sem raça definida, de quatro anos de idade, atendido no Hospital Veterinário da Universidade de Franca (UNIFRAN -SP), que respondeu favoravelmente ao tratamento conservativo instituído.

Paraphimosis, one of the different conditions that can reach the male reproductive system, is a condition characterized by the inability of the penis to retract properly affecting male dogs of different races and ages. The severity is variable, and can lead from reproductive problems to deaths. The aim of this report is to describe a case of paraphimosis in a canine patient, four years, treated at the Veterinary Hospital of the University of Franca (UNIFRAN -SP), who responded favorably to the conservative treatment instituted.

Parafimose traumática: relato em cão

A parafimose, uma das diferentes afecções que podem atingir o sistema reprodutor masculino, é uma condição caracteriza da pela incapacidade do pênis em se retrair corretamente, que atinge cães machos de diferentes raças e idades. A gravidade é variável, podendo acarretar desde problemas reprodutivos a óbito. O objetivo do presente relato é descrever um caso de parafimose em um paciente canino sem raça definida, de quatro anos de idade, atendido no Hospital Veterinário da Universidade de Franca (UNIFRAN -SP), que respondeu favoravelmente ao tratamento conservativo instituído.(AU)

Paraphimosis, one of the different conditions that can reach the male reproductive system, is a condition characterized by the inability of the penis to retract properly affecting male dogs of different races and ages. The severity is variable, and can lead from reproductive problems to deaths. The aim of this report is to describe a case of paraphimosis in a canine patient, four years, treated at the Veterinary Hospital of the University of Franca (UNIFRAN -SP), who responded favorably to the conservative treatment instituted.(AU)