1.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 1): 54-8, 2011 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-21206024
ABSTRACT
The serine protease thrombin plays a major role in thrombosis and haemostasis. This has driven interest in thrombin inhibitors as potential antithrombotic drugs. Here, the crystallization and preliminary crystallographic analysis of human α-thrombin in complex with three noncovalent peptide inhibitors of the general sequence D-Phe-Pro-D-Arg-P1'-CONH2 are reported. The crystals belonged to the orthorhombic space group P2(1)2(1)2(1) and diffracted to beyond 1.3â Å resolution.