ABSTRACT
El empleo de corticoides ante la posibilidad de un parto prematuro ha disminuido la incidencia de distrés respiratorio, hemorragia intraventricular y muerte neonatal. En aquellas mujeres en que el parto se pospone más allá de una semana, el empleo de nuevas dosis semanales ha sido empleado en la práctica obstétrica pese a que hay poca evidencia de su eficacia. Nuevos estudios sugieren en estas pautas repetidas pocos beneficios y riesgos potenciales, por lo que sugieren las dosis únicas (AU)
A single course of corticosteroids given to women before an anticipated preterm birth reduces the incidence of respiratory distress syndrome, intraventricular hemorrhage, and neonatal death. For women who do not deliver within 1 week, administration of repeat courses of corticosteroids has become common obstetric practice, despite little evidence of efficacy. Emerging data suggest that this practice produces little benefit and may potentially be harmful. Therefore, the use of corticosteroids to improve perinatal outcomes should be restricted to a single course (AU)
Subject(s)
Pregnancy , Animals , Male , Female , Rats , Mice , Steroids/administration & dosage , Steroids/adverse effects , Steroids , Risk Factors , Prenatal Care/methods , Prenatal Diagnosis/methods , Fetal Growth Retardation/chemically induced , Fetal Growth Retardation/diagnosis , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/analysis , Prenatal Exposure Delayed Effects , Sheep , Dexamethasone/adverse effects , Betamethasone/adverse effects , Adrenal Cortex Hormones/adverse effects , Retrospective StudiesABSTRACT
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