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1.
J Endocrinol Invest ; 44(2): 255-264, 2021 Feb.
Article in English | MEDLINE | ID: mdl-32449094

ABSTRACT

AIM: To evaluate, in Systemic sclerosis (SSc) patients, the body composition and the bone status according to the peripheral microcirculatory condition, assessed and scored by nailfold videocapillaroscopy (NVC, "Early", "Active", "Late" patterns). METHODS: Body composition and bone mineral density (BMD) were assessed by Dual X-ray absorptiometry and dedicated software (GE Lunar USA) in 37 female SSc patients classified according to the 2013 EULAR/ACR criteria and 40 sex-matched healthy subjects. Clinical, laboratory, body composition and bone parameters were analyzed according to the different NVC patterns. Means were compared by the Student's t test or one-way analysis of variance; medians were compared by the Kruskal-Wallis test; and frequencies by the chi-square test. RESULTS: Higher prevalence of vertebral (21% vs 7%) and femoral (35% vs 7%) osteoporosis (OP) was found in SSc. Particularly SSc patients with "Late" NVC pattern showed a significantly higher prevalence of vertebral (p = 0.018) and femoral OP (p = 0.016). Regional assessment of bone mass (BM) in seven different body areas showed a significantly lower BMD only at the total spine (p = 0.008) and femoral neck (p = 0.027) in advanced microvascular damage. Patients with "Late" NVC pattern showed a lower whole-body lean mass (LM) compared to "Early" and "Active" NVC patterns, particularly at upper limbs. To note, in all body sites, BMD correlates with LM and BMC according to NVC pattern severity. CONCLUSIONS: SSc patients with most severe microvascular damage show a significantly altered body composition and bone status suggesting a strong link between microvascular failure and associated muscle/bone sufferance.


Subject(s)
Bone Diseases, Metabolic/pathology , Microcirculation , Osteoporosis/pathology , Scleroderma, Systemic/complications , Aged , Body Composition , Bone Diseases, Metabolic/epidemiology , Bone Diseases, Metabolic/etiology , Case-Control Studies , Female , Follow-Up Studies , Humans , Italy/epidemiology , Male , Middle Aged , Osteoporosis/epidemiology , Osteoporosis/etiology , Prognosis , Retrospective Studies
3.
Microvasc Res ; 125: 103874, 2019 09.
Article in English | MEDLINE | ID: mdl-30974112

ABSTRACT

OBJECTIVE: The aim of this study was to identify any correlations between microvascular damage, assessed by nailfold videocapillaroscopy and skin impairment, evaluated by three different methods, the modified Rodnan skin score (mRSS), skin high-frequency ultrasound (US) and the plicometer skin test (PST) in systemic sclerosis (SSc) patients. METHODS: Sixty-three SSc patients and 63 healthy subjects were enrolled. Nailfold videocapillaroscopy (NVC) was used to assess the nailfold capillaroscopy pattern ("Early", "Active" or "Late"), according to the Cutolo classification. All subjects were assessed by mRSS, US and PST to evaluate their dermal thickness (DT) in the seventeen skin areas of the body usually evaluated by mRSS (zygoma, fingers, hands, dorsum of hands, forearms, arms, chest, abdomen, thighs, legs, feet). Statistical evaluation was performed by nonparametric tests. RESULTS: All the three methods demonstrated progressively higher values of skin impairment in patients with "Early", "Active" or "Late" pattern of nailfold microangiopathy (for mRSS p < 0.01, US p < 0.02 and PST p < 0.02). A positive correlation was also observed in SSc patients between the three methods used to evaluate skin involvement (mRSS vs US, mRSS vs PST, PST vs US, p < 0.0001 respectively). CONCLUSIONS: This study demonstrates that there is a correlation between two of the most important aspects to classify and monitor the SSc patients, i.e. microvascular damage progression (evaluated by NVC) and skin damage (assessed by mRss, US and PST).


Subject(s)
Capillaries/pathology , Microscopic Angioscopy , Nails/blood supply , Scleroderma, Systemic/pathology , Skin/blood supply , Skin/pathology , Aged , Aged, 80 and over , Case-Control Studies , Disease Progression , Female , Humans , Male , Middle Aged , Observer Variation , Predictive Value of Tests , Prognosis , Reproducibility of Results , Scleroderma, Systemic/diagnostic imaging , Severity of Illness Index , Ultrasonography
4.
Aging Clin Exp Res ; 25 Suppl 1: S27-9, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23963883

ABSTRACT

Osteoporosis is predominantly a condition of the elderly with a consequent increase in bone fragility and susceptibility to fracture. A number of clinical as well as biological studies have been pivotal in providing us with an understanding of the pathophysiology of this condition. This article discusses the current concepts of age-related osteoporosis.


Subject(s)
Osteoporosis/prevention & control , Osteoporosis/therapy , Osteoporotic Fractures/prevention & control , Accidental Falls , Aged , Aged, 80 and over , Aging , Bone Density/drug effects , Female , Hip Fractures/diagnosis , Humans , Life Style , Male , Middle Aged , Osteoporosis/diagnosis , Osteoporosis/epidemiology , Osteoporotic Fractures/diagnosis , Quality of Life , Vitamin D/therapeutic use
5.
Arch. argent. dermatol ; 38(6): 369-82, nov.-dic. 1988. ilus, Tab
Article in Spanish | BINACIS | ID: bin-28884

ABSTRACT

Se resumen los niveles séricos de Cobre (Cu) y Ceruloplasmina (Cp) en medicina general y particularmente en diversos procesos malignos y benignos. Se menciona la hipótesis que vincula las metástasis, el crecicmiento tumoral y la angiogénesis concomitante con la elevación del Cu sérico. Se mensionan los resultados obtenidos en 20 pacientes con melanoma maligno concluyendo que para el Estadio I una elevación brusca de Cu sérico obliga a pensar en una sistematización del proceso oncológico (AU)


Subject(s)
Adult , Middle Aged , Aged , Humans , Male , Female , Biomarkers, Tumor , Copper/metabolism , Ceruloplasmin/metabolism , Melanoma/metabolism , Skin Neoplasms/metabolism , Copper/deficiency , Copper/blood , Ceruloplasmin/physiology , Prognosis
6.
Arch. argent. dermatol ; 38(6): 369-82, nov.-dic. 1988. ilus, tab
Article in Spanish | LILACS | ID: lil-74907

ABSTRACT

Se resumen los niveles séricos de Cobre (Cu) y Ceruloplasmina (Cp) en medicina general y particularmente en diversos procesos malignos y benignos. Se menciona la hipótesis que vincula las metástasis, el crecicmiento tumoral y la angiogénesis concomitante con la elevación del Cu sérico. Se mensionan los resultados obtenidos en 20 pacientes con melanoma maligno concluyendo que para el Estadio I una elevación brusca de Cu sérico obliga a pensar en una sistematización del proceso oncológico


Subject(s)
Adult , Middle Aged , Humans , Male , Female , Ceruloplasmin/metabolism , Copper/metabolism , Melanoma/metabolism , Biomarkers, Tumor , Skin Neoplasms/metabolism , Ceruloplasmin/physiology , Copper/blood , Copper/deficiency , Prognosis
7.
Chemotherapy ; 33(5): 316-21, 1987.
Article in English | MEDLINE | ID: mdl-3665629

ABSTRACT

In order to avoid gentamicin toxicity trough serum concentrations when drug monitoring is not available, a correction factor for serum creatinine was calculated and evaluated. In a first group of 35 patients under aminoglycoside treatment with variable serum creatinine (SCr) values, the regression plot of SCr concentrations versus half-life (T1/2) values was established: log T1/2 = log 2.28 + 1.45 log SCr, r = 0.90, p less than 0.01. A second group of 18 patients was treated with doses of 1.0 mg/kg of gentamicin. Dose intervals equivalent to 3 T1/2 were daily adjusted. The T1/2 was calculated from SCr according to the relationship established for the patients of the first group. All the patients studied maintained trough levels within the therapeutic range.


Subject(s)
Bacterial Infections/drug therapy , Creatinine/blood , Gentamicins/administration & dosage , Adult , Aged , Bacterial Infections/blood , Dose-Response Relationship, Drug , Drug Administration Schedule , Gentamicins/pharmacokinetics , Glomerular Filtration Rate , Half-Life , Humans , Middle Aged
10.
Geogr Med ; 9: 28-37, 1979.
Article in English | MEDLINE | ID: mdl-546680

ABSTRACT

The presence of organochlorinated pesticides in water samples drawn in the Argentine Antarctic Sector and Atlantic coastline has been proved. In general, these samples showed quantities that varied between a few hundredths of a ppmm to slightly more than 1 ppmm, although in some cases and for certain pesticides, depending on the locations, the levels found were definitely higher. With the exception of Dieldrin, which appeared in only one sample/in what would seem to be its course few hundredths of a ppm, to slightly more than 1 ppmm, although in some cases and for certain pesticides found were the same as those reported in previous investigations. The isolated cases of high pesticide contents in water samples drawn at wharves and of snow in the vicinity of Almirante Brown Base show up clearly the influence of human activity on the contamination of the environment.


Subject(s)
Insecticides/isolation & purification , Seawater/analysis , Aldrin/isolation & purification , Antarctic Regions , Argentina , Chromatography, Gas , DDT/isolation & purification , Dichlorodiphenyl Dichloroethylene/isolation & purification , Dieldrin/isolation & purification , Heptachlor/isolation & purification , Hexachlorobenzene/isolation & purification
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