ABSTRACT
Introducción. Los tumores tiroideos son neoplasias de presentación infrecuente en la población pediátrica. El objeto de este estudio fue valorar la evolución terapéutica y seguimiento (supervivencia) a lo largo de 30 años. Materiales. Se revisaron 28 casos con diagnóstico de carcinoma de tiroides desde 1978 a 2008. Las variables a estudiar fueron: epidemiológicas, métodos diagnósticos utilizados, tipo de histología, tratamiento y supervivencia a 300 meses posterior al tratamiento. Consideramos como significativo una p<0,05. Resultados. El 73,1% de los casos fueron de sexo femenino. La edad promedio fue 12,3 años (1,6-19). La ecografía fue la prueba más solicitada (78,5%). La mutación RET se presento en tres casos asociados a MEN. El tipo histológico papilar fue el más frecuente (50%). Latiroidectomía total (TT) fue la cirugía más practicada (67,9%). La radioiodoablación (RIA) se usó en el 46,4% de los casos. La terapia de sustitución hormonal se usó en 27 pacientes de la serie. El 89,29% de la serie al cabo de 300 meses se encontraron libres de enfermedad. Conclusiones. El tratamiento de la serie ha variado a lo largo de (..) (AU)
Introduction. The thyroid tumours are infrequent neoplasms of presentation in paediatric. The object of this study was to value therapeutic evolution and the survival throughout 30 years. Materials. 28 cases with diagnosis of thyroid carcinoma. Were reviewed from 1978 to 2008. Were the variables to study: epidemiologists, methods used diagnostic, type of histology, later treatment and survival to 300 months to the treatment. We like considered significant p <0.05. Results. 73.1% of the cases were of feminine sex. The average age was 12.3 years (1.6 to 19). The ultrasound was asked for the test more(78.5%). The RET mutation associated appear in three cases to MEN. The histology type to papillary was most frequent (50%). The total thyroidectomy (TT) was the (..) (AU)
Subject(s)
Humans , Male , Female , Child , Adolescent , Thyroidectomy/statistics & numerical data , Thyroid Neoplasms/surgery , Thyroid Neoplasms/epidemiology , Risk FactorsABSTRACT
Discusión y revisión de la literatura a partir del caso de un adolescente con síndrome deDown (SD) y sintomatología compatible con encefalitis de Hashimoto (EH).Caso clínico. Varón de 16 años con SD que de forma subaguda inicia síntomas neuropsiquiátricos.Tras confi rmarse una tiroiditis de Hashimoto (TH) y tratado favorablementecon corticoides, se llega al diagnóstico de EH.Discusión. La TH es frecuente sobre todo en pacientes con tendencia a padecer enfermedadesautoinmunes como en el SD. La EH se trata de una patología escasamente descritaen la edad pediátrica, tratable, que sólo ha sido comunicada en 2 pacientes con SD (AU)
This review and discussion of current literature is based on the case of a teenager withDown syndrome (DS) who presents symptoms compatible with Hashimotos encephalitis(HE).Clinical case. A sixteen-year-old male with DS had a subacute onset of neuropsychiatricsymptoms. Hashimotos thyroiditis (HT) was confi rmed and steroid treatment initiated,with positive results, so the diagnosis of HE was made.Discussion. HT is a particularly common disease among patients that usually haveautoimmune disorders, such as persons with DS. HE is a treatable condition that is poorlyrecognized in children and has been reported only twice with DS (AU)
Subject(s)
Humans , Male , Adolescent , Hashimoto Disease/complications , Hashimoto Disease/diagnosis , Down Syndrome/complications , Adrenal Cortex Hormones/therapeutic use , Psychomotor Agitation/complications , Steroids/therapeutic use , Methylprednisolone/therapeutic use , Prednisone/therapeutic use , Intellectual Disability/complications , Intellectual Disability/psychology , Autistic Disorder/complications , Autistic Disorder/diagnosis , Immunologic Factors/pharmacologyABSTRACT
INTRODUCTION: The thyroid tumours are infrequent neoplasms of presentation in paediatric. The object of this study was to value therapeutic evolution and the survival throughout 30 years. MATERIALS: 28 cases with diagnosis of thyroid carcinoma. Were reviewed from 1978 to 2008. Were the variables to study: epidemiologists, methods used diagnostic, type of histology, later treatment and survival to 300 months to the treatment. We like considered significant p <0.05. RESULTS: 73.1% of the cases were of feminine sex. The average age was 12.3 years (1.6 to 19). The ultrasound was asked for the test more (78.5%). The RET mutation associated appear in three cases to MEN. The histology type to papillary was most frequent (50%). The total thyroidectomy (TT) was the surgery practice more (67.9%). The radioiodine (RI) was used in 46.4% of the cases. The substitute hormonal therapy was used 27 patients. 89.29% of the were series after 300 months free of disease. CONCLUSIONS: The treatment of the series these are hundreds throughout 30 years, but when valuing our experience we include / understand that: 1) the TT with selective lymphatic dissection, 2) it in the RI cases with positive to the body tracking and/or of factors of risk and 3) the substitute hormonal therapy, is the at the moment best offer alternatives to than we can these paediatric patients and prolong the survival in adult its age.
Subject(s)
Thyroid Neoplasms , Adolescent , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Male , Survival Rate , Thyroid Neoplasms/mortality , Thyroid Neoplasms/therapy , Time Factors , Young AdultSubject(s)
Carotid Artery, Internal/abnormalities , Ear, Middle/abnormalities , Adolescent , Carotid Artery, Internal/diagnostic imaging , Congenital Abnormalities/diagnosis , Diagnosis, Differential , Ear, Middle/diagnostic imaging , Female , Humans , Male , Middle Aged , Tomography, X-Ray ComputedABSTRACT
We designed a strategy to select genomic clones of mouse replication-independent H3.3 histone genes. We obtained three clones which met our selection criteria for being H3.3 genes. Upon sequencing two of these clones we found that they were unlike previously isolated chicken H3.3 clones: they code for several unpredicted amino acid substitutions and contain no introns in the coding regions. We showed by S1 nuclease assays that these genes are protected by mRNAs that have expression characteristics of H3.3 mRNA. The protection data and nucleotide sequence analysis show that the H3.3 transcripts can be processed at one of four cleavage/polyadenylation sites. We show that these genes probably evolved through reverse transcription intermediates, and are processed pseudogenes which are no longer under selective pressure. The 5' and 3' transcribed, nontranslated sequences show extensive homology to those of a human cDNA clone, and we suggest that these sequences may be required for appropriate regulation of expression of H3.3 genes.
Subject(s)
DNA/genetics , Histones/genetics , Pseudogenes , Animals , Biological Evolution , Humans , Mice , Molecular Sequence Data , Nucleic Acid Hybridization , RNA/genetics , Ribonucleases/analysis , Sequence Homology, Nucleic AcidABSTRACT
The bacteriological examination of 100 butchers' blocks has led to the identification of eight strains (two from the same sample) of Salmonella belonging to the following serotypes: S. wien, S. coeln (horsemeat), S. newport (poultry), S. infantis, S. derby, S. panama, S. bredeney, S. sofia. The relative importance of these serotypes in the region of Toulon is considered and compared to the frequency of human serotypes, the most important of which is S. typhi murium. The methods used for isolation seem to have little influence on these apparently-conflicting results.
