ABSTRACT
Entre las sustancias prohibidas por la Agencia Mundial Antidopaje, en el apartado S2 se clasifican como prohibidas, tanto en competición como fuera de competición, las «hormonas peptídicas, factores de crecimiento y sustancias relacionadas y miméticos». En este trabajo realizamos una revisión de: la hormona de crecimiento y sus péptidos liberadores; el factor de crecimiento similar a la insulina tipo 1 como principal factor de crecimiento; la insulina, y la eritropoyetina y otros agentes que afectan la eritropoyesis. En esta revisión analizamos la prevalencia de uso en deportistas profesionales y clientes de gimnasios; las formas de uso, dosis, efectos ergogénicos y sobre el rendimiento físico, así como los efectos secundarios y métodos de detección antidopaje (AU)
Among the substances prohibited by the World Anti-Doping Agency, peptide hormones, growth factors, related substances, and mimetics are classified as prohibited both in- and out-of-competition in section S2. This work reviews growth hormone and its releasing peptides, insulin-like growth factor 1 as the main growth factor, insulin, and erythropoietin and other agents that affect erythropoiesis. This review analyzes the prevalence of use among professional athletes and gym clients, the forms of use, dosing, ergogenic effects and effects on physical performance, as well as side effects and anti-doping detection methods (AU)
Subject(s)
Humans , Doping in Sports , Epoetin Alfa/pharmacology , Erythropoietin/pharmacology , Human Growth Hormone/pharmacology , Erythropoiesis/drug effects , Insulin-Like Growth Factor I , Insulin, Regular, HumanABSTRACT
Among the substances prohibited by the World Anti-Doping Agency, "peptide hormones, growth factors, related substances, and mimetics" are classified as prohibited both in- and out-of-competition in section S2. This work reviews growth hormone and its releasing peptides, insulin-like growth factor 1 as the main growth factor, insulin, and erythropoietin and other agents that affect erythropoiesis. This review analyzes the prevalence of use among professional athletes and gym clients, the forms of use, dosing, ergogenic effects and effects on physical performance, as well as side effects and anti-doping detection methods.
Subject(s)
Doping in Sports , Erythropoietin , Human Growth Hormone , Humans , Growth Hormone , Insulin , Insulin-Like Growth Factor I/adverse effects , Epoetin Alfa , Insulin, Regular, HumanABSTRACT
El consumo de anabolizantes hormonales afecta no solamente a atletas profesionales, sino también a la población general (culturistas, clientes de gimnasios y adolescentes entre otros). En el primer caso su uso está prohibido y sancionado por la Agencia Mundial Anti-Dopaje y los comités olímpicos. Para los segundos es difícil establecer la prevalencia ya que muchos obtienen los productos a través de compras por Internet. Los motivos para su uso son diversos y se han descrito distintas formas de uso, así como diferentes tipologías de consumidores. Entre los efectos secundarios, el hipogonadismo es la causa más frecuente de consulta endocrinológica. En esta revisión se describen, tras una introducción general al dopaje, los antecedentes históricos de los andrógenos anabolizantes, su clasificación, las formas de uso, los efectos fisiológicos, los efectos adversos en diferentes órganos y sistemas, el tratamiento del hipogonadismo, así como los métodos de detección (AU)
The use of anabolic steroids affects not only professional athletes but also the general population (bodybuilders, gym clients, and adolescents). In the first case, its use is prohibited and sanctioned by the World Anti-Doping Agency and Olympic committees. For the other users, it is difficult to establish its prevalence since many obtain the products via the Internet. The reasons for its use are varied and different forms of use and other types of users have been described. Among the side effects of steroid use, hypogonadism is the most frequent cause for endocrinological consultation. After a general introduction to doping, this review describes the historical background of anabolicandrogenic steroids, their classification, forms of use, physiological effects, adverse effects on different organs and systems, treatment of hypogonadism, as well as detection methods (AU)
Subject(s)
Humans , Anabolic Agents/administration & dosage , Androgens/administration & dosage , Hypogonadism/chemically induced , Doping in Sports , Anabolic Agents/adverse effects , Androgens/adverse effects , Hypogonadism/therapyABSTRACT
The use of anabolic steroids affects not only professional athletes but also the general population (bodybuilders, gym clients, and adolescents). In the first case, its use is prohibited and sanctioned by the World Anti-Doping Agency and Olympic committees. For the other users, it is difficult to establish its prevalence since many obtain the products via the internet. The reasons for its use are varied and different forms of use and other types of users have been described. Among the side effects of steroid use, hypogonadism is the most frequent cause for endocrinological consultation. After a general introduction to doping, this review describes the historical background of anabolic-androgenic steroids, their classification, forms of use, physiological effects, adverse effects on different organs and systems, treatment of hypogonadism, as well as detection methods.
Subject(s)
Anabolic Agents , Hypogonadism , Sports , Adolescent , Humans , Anabolic Agents/adverse effects , Anabolic Androgenic Steroids , Testosterone Congeners/adverse effects , Athletes , Hypogonadism/chemically inducedABSTRACT
OBJECTIVES: To analyze by means of a systematic review the general knowledge about strokes of the Spanish population. MATERIALS AND METHODS: A systematic review is performed following PRISMA guidelines and with data from PubMed, Scopus and EMBASE. All studies carried out in Spain, centred around the knowledge of strokes are compiled (terminology, pathophysiology, signs and symptoms, risk factors, treatment, and willingness to make use of the Emergency Services). From the 4,627 articles collected, 21 were ultimately included in this review. RESULTS: In Spain, the term stroke is less known than others such as embolism or cerebrovascular accident. Loss of strength is the most widely recognized symptom, whereas arterial hypertension is the most widely identified risk factor. The least known symptom and risk factor are visual impairment and diabetes mellitus, respectively. When faced with a suspected stroke, the attitude of most respondents is adequate as they decide to go to the hospital or call the Emergency Services. However, in rural areas or in cases in which the symptoms suddenly stop, a greater number of participants choose to go to their family physician. The main sources of information of the participants are their family members and their doctors. CONCLUSIONS: General knowledge about strokes is scarce among the general population. Nonetheless, the attitude of most of the participants is adequate as they choose to contact specialized Emergency Services.
TITLE: Conocimiento sobre el ictus en la población española. Una revisión sistemática.Objetivos. Analizar mediante una revisión sistemática el estado de conocimiento sobre el ictus en la población española. Materiales y métodos. Se ha llevado a cabo una revisión sistemática siguiendo las directrices PRISMA en las bases de datos PubMed, Scopus y EMBASE. Se incorporaron todos los estudios realizados en España que versaran sobre el conocimiento del ictus (terminología, fisiopatología, síntomas y signos, factores de riesgo, tratamiento e intención de acudir a servicios de emergencias). Se identificaron 4.627 artículos, de los cuales 21 se incluyeron finalmente en la revisión. Resultados. El término ictus es menos reconocido que otros, como embolia o infarto cerebral. La pérdida de fuerza es el síntoma más reconocido y la hipertensión arterial es el factor de riesgo más identificado. El síntoma y el factor de riesgo menos reconocidos son los déficits visuales y la diabetes mellitus, respectivamente. Ante la sospecha de ictus, la actitud de la mayoría de los encuestados es adecuada, ya que eligen acudir al hospital o llamar a los servicios de emergencias. Sin embargo, en el medio rural, y ante síntomas que ceden espontáneamente, un mayor número de participantes elige acudir a su médico de familia. Las principales fuentes de información de los participantes son sus familiares y médicos. Conclusiones. El conocimiento global sobre el ictus es escaso entre la población española. Sin embargo, la actitud de la mayoría de los participantes es adecuada, ya que elige mayoritariamente contactar con servicios de emergencias especializados.
Subject(s)
Emergency Medical Services , Hypertension , Stroke , Health Knowledge, Attitudes, Practice , Humans , Hypertension/epidemiology , Risk Factors , Stroke/epidemiologyABSTRACT
Objetivos: Analizar mediante una revisión sistemática el estado de conocimiento sobre el ictus en la población española. Materiales y métodosSe ha llevado a cabo una revisión sistemática siguiendo las directrices PRISMA en las bases de datos PubMed, Scopus y EMBASE. Se incorporaron todos los estudios realizados en España que versaran sobre el conocimiento del ictus (terminología, fisiopatología, síntomas y signos, factores de riesgo, tratamiento e intención de acudir a servicios de emergencias). Se identificaron 4.627 artículos, de los cuales 21 se incluyeron finalmente en la revisión. Resultados: El término ictus es menos reconocido que otros, como embolia o infarto cerebral. La pérdida de fuerza es el síntoma más reconocido y la hipertensión arterial es el factor de riesgo más identificado. El síntoma y el factor de riesgo menos reconocidos son los déficits visuales y la diabetes mellitus, respectivamente. Ante la sospecha de ictus, la actitud de la mayoría de los encuestados es adecuada, ya que eligen acudir al hospital o llamar a los servicios de emergencias. Sin embargo, en el medio rural, y ante síntomas que ceden espontáneamente, un mayor número de participantes elige acudir a su médico de familia. Las principales fuentes de información de los participantes son sus familiares y médicos. Conclusiones: El conocimiento global sobre el ictus es escaso entre la población española. Sin embargo, la actitud de la mayoría de los participantes es adecuada, ya que elige mayoritariamente contactar con servicios de emergencias especializados.(AU)
Objectives: To analyze by means of a systematic review the general knowledge about strokes of the Spanish population. Materials and methods: A systematic review is performed following PRISMA guidelines and with data from PubMed, Scopus and EMBASE. All studies carried out in Spain, centred around the knowledge of strokes are compiled (terminology, pathophysiology, signs and symptoms, risk factors, treatment, and willingness to make use of the Emergency Services). From the 4,627 articles collected, 21 were ultimately included in this review. Results: In Spain, the term stroke is less known than others such as embolism or cerebrovascular accident. Loss of strength is the most widely recognized symptom, whereas arterial hypertension is the most widely identified risk factor. The least known symptom and risk factor are visual impairment and diabetes mellitus, respectively. When faced with a suspected stroke, the attitude of most respondents is adequate as they decide to go to the hospital or call the Emergency Services. However, in rural areas or in cases in which the symptoms suddenly stop, a greater number of participants choose to go to their family physician. The main sources of information of the participants are their family members and their doctors. Conclusions: General knowledge about strokes is scarce among the general population. Nonetheless, the attitude of most of the participants is adequate as they choose to contact specialized Emergency Services.(AU)
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Stroke , Cerebrovascular Disorders , Key Symptoms , Symptom Assessment , Risk Factors , Spain , NeurologyABSTRACT
INTRODUCCIÓN: Existe un interés creciente en la aplicación de la resonancia magnética funcional (RMf) en el abordaje prequirúrgico de la cirugía de la epilepsia. Tradicionalmente, esta técnica precisa la colaboración del paciente en la realización de tareas concretas; sin embargo, en la actualidad, se estudia la posibilidad de realizarla sin necesidad de colaboración en la modalidad de estado de reposo. OBJETIVO: Estudiar las utilidades clínicas de la RMf en estado de reposo en la planificación de la cirugía de la epilepsia del lóbulo temporal. Desarrollo. Se realizó una revisión mediante la búsqueda bibliográfica en diferentes bases de datos: PubMed, Science Direct, Scopus y Cochrane. Se incluyeron estudios en inglés y castellano que utilizaron la RMf en estado de reposo, excluyendo los artículos de pacientes exclusivamente pediátricos o relacionados con la existencia de tumores u otras patologías estructurales diferentes a la esclerosis temporal. Se encontraron 11 artículos que estudiaron las utilidades clínicas en la aplicación de la RMf en estado de reposo en el contexto de la cirugía de la epilepsia. En cinco se intenta determinar el hemisferio epileptógeno, en dos se propone como objetivo la predicción pronóstica de la mejoría de las crisis epilépticas y en cuatro se estudia la posibilidad de predecir el deterioro de diversas funciones cognitivas tras la cirugía. Concusión. La RMf en estado de reposo es una técnica con un gran potencial para convertirse en una herramienta útil en el contexto de la planificación de la cirugía de la epilepsia y en la predicción de la morbilidad postoperatoria
INTRODUCTION: There is a growing interest in the functional magnetic resonance imaging (fMRI) and his clinical applications in the planning of the epilepsy surgery. The conventional method of using the fMRI require the cooperation of the patient. Currently it is being studied the possibility of using this technique without the performance of specifi c tasks by the patient in the modality of resting state. AIM: To study the clinical applications of the fMRI in resting state, in the planning of the temporal epilepsy surgery. Development. We carried out a systematic review helped by a bibliographic research in diff erent databases, including PubMed, Science Direct, Scopus and Cochrane. We included articles focused on the use of resting state fMRI written in Spanish and English, excluding studies exclusively focused on pediatric patients or related with the presence of epileptogenic tumors and other structural pathologies except for the temporal sclerosis. We found 11 articles which describe different clinical applications for the resting state fMRI in the context of epilepsy surgery. In fi ve, the objective was to identify the epileptogenic hemisphere; in two, it was planned to predict the improvement of the disease; and in four of the articles, it has been studied the possibility of predicting worsening of cognitive functions that are frequently aff ected after the surgery. CONCLUSION: The resting state fMRI is a technique with a great potential of developing an useful tool in the context of planning the epilepsy surgery, as well as in the prediction of postsurgical morbidity
Subject(s)
Humans , Epilepsy, Temporal Lobe/diagnostic imaging , Epilepsy, Temporal Lobe/surgery , Neurosurgery/methods , Magnetic Resonance Imaging , RestABSTRACT
INTRODUCTION: There is a growing interest in the functional magnetic resonance imaging (fMRI) and his clinical applications in the planning of the epilepsy surgery. The conventional method of using the fMRI require the cooperation of the patient. Currently it is being studied the possibility of using this technique without the performance of specific tasks by the patient in the modality of resting state. AIM: To study the clinical applications of the fMRI in resting state, in the planning of the temporal epilepsy surgery. DEVELOPMENT: We carried out a systematic review helped by a bibliographic research in different databases, including PubMed, Science Direct, Scopus and Cochrane. We included articles focused on the use of resting state fMRI written in Spanish and English, excluding studies exclusively focused on pediatric patients or related with the presence of epileptogenic tumors and other structural pathologies except for the temporal sclerosis. We found 11 articles which describe different clinical applications for the resting state fMRI in the context of epilepsy surgery. In five, the objective was to identify the epileptogenic hemisphere; in two, it was planned to predict the improvement of the disease; and in four of the articles, it has been studied the possibility of predicting worsening of cognitive functions that are frequently affected after the surgery. CONCLUSION: The resting state fMRI is a technique with a great potential of developing an useful tool in the context of planning the epilepsy surgery, as well as in the prediction of postsurgical morbidity.
TITLE: Aplicaciones de la resonancia magnética funcional en estado de reposo en la cirugía de la epilepsia del lóbulo temporal.Introducción. Existe un interés creciente en la aplicación de la resonancia magnética funcional (RMf) en el abordaje prequirúrgico de la cirugía de la epilepsia. Tradicionalmente, esta técnica precisa la colaboración del paciente en la realización de tareas concretas; sin embargo, en la actualidad, se estudia la posibilidad de realizarla sin necesidad de colaboración en la modalidad de estado de reposo. Objetivo. Estudiar las utilidades clínicas de la RMf en estado de reposo en la planificación de la cirugía de la epilepsia del lóbulo temporal. Desarrollo. Se realizó una revisión mediante la búsqueda bibliográfica en diferentes bases de datos: PubMed, Science Direct, Scopus y Cochrane. Se incluyeron estudios en inglés y castellano que utilizaron la RMf en estado de reposo, excluyendo los artículos de pacientes exclusivamente pediátricos o relacionados con la existencia de tumores u otras patologías estructurales diferentes a la esclerosis temporal. Se encontraron 11 artículos que estudiaron las utilidades clínicas en la aplicación de la RMf en estado de reposo en el contexto de la cirugía de la epilepsia. En cinco se intenta determinar el hemisferio epileptógeno, en dos se propone como objetivo la predicción pronóstica de la mejoría de las crisis epilépticas y en cuatro se estudia la posibilidad de predecir el deterioro de diversas funciones cognitivas tras la cirugía. Concusión. La RMf en estado de reposo es una técnica con un gran potencial para convertirse en una herramienta útil en el contexto de la planificación de la cirugía de la epilepsia y en la predicción de la morbilidad postoperatoria.
Subject(s)
Epilepsy, Temporal Lobe/diagnostic imaging , Epilepsy, Temporal Lobe/surgery , Magnetic Resonance Imaging/methods , Humans , RestABSTRACT
INTRODUCCIÓN: El tratamiento quirúrgico de los pacientes con epilepsia mesial del lóbulo temporal refractaria al tratamiento farmacológico conlleva el riesgo de deterioro de la memoria, siendo así importante una correcta selección de los pacientes. Sin embargo, no existe un consenso claro en cuanto a qué métodos de la evaluación prequirúrgica de la memoria permitirían predecir mejor sus cambios tras la cirugía para identificar a aquellos pacientes con mayor riesgo de deterioro. OBJETIVOS: Identificar qué métodos de evaluación de la memoria podrían ser más útiles en la predicción de sus posibles cambios tras la cirugía, a través de una revisión sistemática de la literatura. MATERIAL Y MÉTODOS: Se realizó una búsqueda de los estudios publicados entre los años 2005 y 2015 en la base de datos Pubmed, incorporando aquellos en los que se evaluaba la memoria, mediante test neuropsicológicos, neuroimagen funcional, y otras, antes y después de la intervención neuroquirúrgica en pacientes con epilepsia mesial del lóbulo temporal, con objeto de predecir sus cambios. Se identificaron 178 artículos, de los cuales 31 fueron finalmente incluidos en la revisión. RESULTADOS: La mayoría de los estudios utilizan test neuropsicológicos y RM funcional, con una amplia variedad de técnicas diferentes, que son los métodos con mayor utilidad predictiva. Otras técnicas, como el test de Wada o el FDG-PET, son menos utilizadas. CONCLUSIONES: La evidencia actual apoya que una evaluación prequirúrgica adecuada de la memoria mediante test neuropsicológicos y RM funcional constituye el mejor modo de predicción de sus cambios tras la cirugía
INTRODUCTION: Given that surgical treatment of refractory mesial temporal lobe epilepsy may cause memory impairment, determining which patients are eligible for surgery is essential. However, there is little agreement on which presurgical memory assessment methods are best able to predict memory outcome after surgery and identify those patients with a greater risk of surgery-induced memory decline. OBJECTIVE: We conducted a systematic literature review to determine which presurgical memory assessment methods best predict memory outcome. MATERIAL AND METHODS: The literature search of PubMed gathered articles published between January 2005 and December 2015 addressing pre- and postsurgical memory assessment in mesial temporal lobe epilepsy patients by means of neuropsychological testing, functional MRI, and other neuroimaging techniques. We obtained 178 articles, 31 of which were included in our review. RESULTS: Most of the studies used neuropsychological tests and fMRI; these methods are considered to have the greatest predictive ability for memory impairment. Other less frequently used techniques included the Wada test and FDG-PET. CONCLUSIONS: Current evidence supports performing a presurgical assessment of memory function using both neuropsychological tests and functional MRI to predict memory outcome after surgery
Subject(s)
Humans , Epilepsy, Temporal Lobe/surgery , Memory Disorders/diagnosis , Neuropsychological Tests , Magnetic Resonance ImagingABSTRACT
INTRODUCTION: Musicogenic epilepsy is a type of reflex complex epilepsy and is evoked by musical stimulus, specially music with high emotional content to the patient. AIM: To review the state of the art of the musicogenic epilepsy in the current literature. DEVELOPMENT: We have made an analysis of all the patients that have been described with musicogenic epilepsy. Among the most studied variables we have included: the nature of the sound that evoke the seizure, the musical education of the patients, the changes between the different neurophysiological and neuroimaging techniques, the most frequent location and the hemispheric side implication in seizures, and comparison between the different neuroimaging techniques. Most of the patients had seizures when they were listening to music with emotional content. The right temporal lobe is the most affected area in this type of epilepsy. In these studies the structural neuroimaging were normal in most of the patients. CONCLUSIONS: Musicogenic epilepsy is reflex and complex and music with emotional content to the patients is the most frequent stimulus that evoke this type of epilepsy. The right temporal lobe is the most affected area. It seems that exists a correlation between emotional and auditory cerebral processing networks.
TITLE: Conocimiento actual de la epilepsia musicogena: revision de la literatura cientifica.Introduccion. La epilepsia musicogena se clasifica dentro del grupo de las epilepsias reflejas complejas y se caracteriza por desencadenarse con estimulos musicales, especialmente con fragmentos musicales con alta emotividad en la melodia. Objetivo. Revisar el conocimiento actual de las epilepsias musicogenas en la literatura cientifica. Desarrollo. Se ha realizado una revision detallada de los articulos que versan sobre epilepsia musicogena. Para ello se ha llevado a cabo un analisis de todos los casos clinicos descritos en la bibliografia hasta febrero de 2019. Entre las variables mas frecuentes se han estudiado: el tipo de estimulo sonoro desencadenante de las crisis, la presencia o no de educacion musical del paciente, los cambios en las diferentes pruebas complementarias neurofisiologicas y de neuroimagen, y la localizacion y lateralidad hemisferica implicada en este fenomeno. La mayoria de los pacientes tiene crisis evocadas por musica con contenido emocional para ellos. El lobulo temporal derecho es el mas frecuentemente implicado en este tipo de crisis, pero en la mayoria de los casos no se han observado alteraciones estructurales en las pruebas de neuroimagen. Conclusiones. La epilepsia musicogena es refleja y compleja y se caracteriza por desencadenarse con estimulos musicales. La zona que mas se afecta en las pruebas funcionales es el lobulo temporal derecho. Se piensa que existe una relacion entre las redes cerebrales que se encargan del procesamiento de las emociones a traves del estimulo auditivo y el desarrollo de este tipo de epilepsia.
Subject(s)
Epilepsy, Reflex/etiology , Music , Adolescent , Adult , Aged , Child , Child, Preschool , Electroencephalography , Emotions/physiology , Epilepsy, Reflex/diagnostic imaging , Epilepsy, Reflex/physiopathology , Female , Humans , Infant , Male , Middle Aged , Neuroimaging , Temporal Lobe/physiopathology , Young AdultABSTRACT
INTRODUCTION: Given that surgical treatment of refractory mesial temporal lobe epilepsy may cause memory impairment, determining which patients are eligible for surgery is essential. However, there is little agreement on which presurgical memory assessment methods are best able to predict memory outcome after surgery and identify those patients with a greater risk of surgery-induced memory decline. OBJECTIVE: We conducted a systematic literature review to determine which presurgical memory assessment methods best predict memory outcome. MATERIAL AND METHODS: The literature search of PubMed gathered articles published between January 2005 and December 2015 addressing pre- and postsurgical memory assessment in mesial temporal lobe epilepsy patients by means of neuropsychological testing, functional MRI, and other neuroimaging techniques. We obtained 178 articles, 31 of which were included in our review. RESULTS: Most of the studies used neuropsychological tests and fMRI; these methods are considered to have the greatest predictive ability for memory impairment. Other less frequently used techniques included the Wada test and FDG-PET. CONCLUSIONS: Current evidence supports performing a presurgical assessment of memory function using both neuropsychological tests and functional MRI to predict memory outcome after surgery.
Subject(s)
Epilepsy, Temporal Lobe/surgery , Memory Disorders/diagnosis , Neuropsychological Tests , Humans , Magnetic Resonance ImagingABSTRACT
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease which involves, among other manifestations, a progressive deterioration of memory and language, as well as behavioral disorders. In addition to non-curative pharmacological therapies, for the last years, music therapy has been developed as an effective non-pharmacological therapy in order to relieve many of these manifestations. AIM: To analyze the recent scientific evidence about the effect of music therapy on cognitive and behavioral symptoms in patients with AD. PATIENTS AND METHODS: A systematic review has been carried out by means of a bibliographical research using the database PubMed and Science Direct. The key words used for this search were 'Alzheimer's disease' and 'music therapy', as well as the boolean operator 'AND'. We selected those publications between January 2006 and December 2016 and after inclusion criteria, 21 publications were selected. RESULTS: This systematic review has demonstrated the beneficial impact of music therapy on cognition (memory, attention, language), emotion and behavior (anxiety, depression and agitation) in AD patients. CONCLUSIONS: Music therapy constitutes a non-pharmacological therapy effective for some cognitive, emotional and behavioral symptoms in patients with AD. However, further investigations and more evidence in this field are needed to claim conclusively the impact of music therapy on this disease.
TITLE: Efecto de la musicoterapia como terapia no farmacologica en la enfermedad de Alzheimer. Revision sistematica.Introduccion. La enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo que conlleva, entre otras manifestaciones, una afectacion progresiva de alteraciones cognitivas, como la memoria y el lenguaje, asi como de alteraciones conductuales. Ademas de las terapias farmacologicas no curativas, la terapia con musica viene asentandose en los ultimos anos como una terapia no farmacologica eficaz para paliar muchas de las manifestaciones clinicas de la enfermedad. Objetivo. Analizar la evidencia cientifica reciente sobre el efecto de la musicoterapia en los sintomas cognitivos y conductuales en pacientes con EA. Pacientes y metodos. Se ha realizado una revision sistematica mediante una busqueda bibliografica en las bases de datos PubMed y Science Direct, empleando como palabras clave 'Alzheimer's disease' y 'music therapy', y el operador booleano 'AND'. Se consideraron los trabajos publicados entre enero de 2006 y diciembre de 2016 y, tras los criterios de inclusion, se seleccionaron 21 estudios. Resultados. Esta revision sistematica demuestra el efecto beneficioso de la musicoterapia sobre el estado cognitivo (memoria, atencion, lenguaje), emocional y conductual (ansiedad, depresion y agitacion) de los pacientes con EA. Conclusiones. La musicoterapia constituye una terapia no farmacologica eficaz para determinados sintomas cognitivos, emocionales y conductuales de pacientes con EA. No obstante, se necesitan mas investigaciones en este campo para poder definir de forma mas concluyente el efecto que produce la musicoterapia en esta patologia.
Subject(s)
Alzheimer Disease/therapy , Music Therapy , Alzheimer Disease/psychology , Behavior , Cognition , Emotions , Humans , Language , Memory , Quality of Life , Treatment OutcomeABSTRACT
Introducción: La asistencia telefónica a demanda (ATAD) es una práctica habitual en las consultas de Neurología; no obstante, los estudios que valoran dicha modalidad de asistencia sanitaria son escasos. Hemos evaluado la ATAD en cuidadores de pacientes con enfermedad de Alzheimer (EA) desde el punto de vista económico y de la satisfacción percibida por el cuidador principal. Pacientes y métodos: Se seleccionó a 97 pacientes con diagnóstico de EA según criterios NINCDS-ADRDA y sus respectivos 97 cuidadores principales. Estudiamos los gastos diferenciales entre las modalidades asistenciales presencial y a demanda a lo largo de 12 meses. A los 12 meses se valoró la satisfacción de los cuidadores principales mediante un cuestionario autoadministrado. Resultados: El ahorro que supuso la ATAD frente la asistencia presencial fue de 80,05 ± 27,07 euros por usuario. Al 73,6% de los cuidadores que usaron la ATAD les parece mejor o mucho mejor esta que la asistencia presencial, mientras que al 2,6% de los cuidadores les parece peor o mucho peor. Conclusiones: La ATAD supone un servicio de salud eficiente en el seguimiento de los usuarios con EA en las consultas de Neurología y la satisfacción de los usuarios fue alta, por lo que consideramos que debería incluirse en la cartera de servicios del sistema sanitario (AU)
Introduction: Telephone assistance is a common practice in neurology, although there are only a few studies about this type of healthcare. We have evaluated a Telephone Assistance System (TAS) for caregivers of patients with Alzheimer's disease (AD) from 2 points of view: financially and according to the level of satisfaction of the caregiver. Patients and methods: 97 patients with a diagnosis of AD according to NINCDS-ADRDA criteria and their 97 informal caregivers were selected. We studied cost differences between on-site assistance and telephone assistance (TAS) for 12 months. We used a self-administered questionnaire to assess the level of satisfaction of caregivers at the end of the study period. Results: TAS savings amounted to 80.05 ± 27.07 euros per user. 73.6% of the caregivers consider TAS a better or much better system than on-site assistance, while only 2.6% of the caregivers considered TAS a worse or much worse system than on-site assistance. Conclusions: Telephone assistance systems are an efficient healthcare resource for monitoring patients with AD in neurology departments. Furthermore, the level of user satisfaction was high. We therefore consider that telephone assistance service should be offered by healthcare services (AU)
Subject(s)
Humans , Alzheimer Disease/epidemiology , Caregivers/psychology , Dementia/epidemiology , Nursing Care/methods , Telephone , Home Nursing/methods , Remote Consultation , Personal SatisfactionABSTRACT
Introducción: Los cuidadores de pacientes con enfermedad de Alzheimer (EA) tienen un deterioro de su calidad de vida relacionada con la salud (CVRS). La CVRS es una medida de resultado centrada en el usuario cada vez más usada. Evaluamos de forma longitudinal la CVRS en cuidadores de pacientes con EA, antes y después, durante un periodo de 12 meses. Métodos: Se incluyó en el estudio a 97 pacientes diagnosticados de EA según criterios NINCDS-ADRDA (Instituto Nacional de Trastornos Neurológicos y de la Comunicación y Accidente Cerebrovascular y Asociación de Enfermedad de Alzheimer y Trastornos relacionados) y sus respectivos 97 cuidadores principales. Se analizaron datos sociodemográficas de ambos, clínicos de los pacientes, y datos en relación con el cuidado en la visita basal. La CVRS se midió con el cuestionario SF-36 en la visita basal y a los 12 meses. Resultados: Las 8 dimensiones de la escala SF-36 en los cuidadores principales empeoraron de forma significativa a los 12 meses, salvo las dimensiones «Función física» y «Función social», que lo hicieron de forma no significativa. Las puntuaciones en la visita basal fueron menores que las correspondientes a la población general. La dimensión que presentó peor puntuación fue «Vitalidad». Conclusiones: La CVRS en cuidadores de pacientes con EA empeora a lo largo de la evolución de esta y es peor que la de la población general, para su edad y género (AU)
Introduction: Informal caregivers of patients with Alzheimer's disease (AD) have a poor health-related quality of life (HRQOL). HRQOL is an increasingly common user-focused outcome measure. We have evaluated HRQOL longitudinally in caregivers of AD patients at baseline and at 12 months. Methods: Ninety-seven patients diagnosed with AD according to the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke, and Alzheimer's Disease and Related Disorders Association) and their 97 respective primary caregivers were included in the study. We analysed the following data at the baseline visit: sociodemographic data of both patients and carers, patients clinical variables, and data related to the healthcare provided to patients by carers. HRQOL of caregivers was measured with the SF-36 questionnaire at baseline and 12 months later. Results: At 12 months, primary caregivers scored lower in the 8 subscales of the SF-36 questionnaire; differences were statistically significant in all dimensions except for physical function and social function. Baseline scores in our sample were lower than those of the general population. Vitality is the dimension that presented the lowest scores. Conclusion: HRQOL in caregivers of patients with Alzheimer's disease deteriorates over time and is poorer than that of the age- and sex-matched general population (AU)
Subject(s)
Humans , Alzheimer Disease/psychology , Caregivers/psychology , Psychometrics/instrumentation , Dementia/psychology , Quality of Life , Sickness Impact Profile , Longitudinal Studies , Psychiatric Status Rating ScalesABSTRACT
INTRODUCTION: Telephone assistance is a common practice in neurology, although there are only a few studies about this type of healthcare. We have evaluated a Telephone Assistance System (TAS) for caregivers of patients with Alzheimer's disease (AD) from 2 points of view: financially and according to the level of satisfaction of the caregiver. PATIENTS AND METHODS: 97 patients with a diagnosis of AD according to NINCDS-ADRDA criteria and their 97 informal caregivers were selected. We studied cost differences between on-site assistance and telephone assistance (TAS) for 12 months. We used a self-administered questionnaire to assess the level of satisfaction of caregivers at the end of the study period. RESULTS: TAS savings amounted to 80.05 ± 27.07 euros per user. 73.6% of the caregivers consider TAS a better or much better system than on-site assistance, while only 2.6% of the caregivers considered TAS a worse or much worse system than on-site assistance. CONCLUSIONS: Telephone assistance systems are an efficient healthcare resource for monitoring patients with AD in neurology departments. Furthermore, the level of user satisfaction was high. We therefore consider that telephone assistance service should be offered by healthcare services.
Subject(s)
Alzheimer Disease/psychology , Caregivers/psychology , Personal Satisfaction , Telephone , Aged , Alzheimer Disease/economics , Female , Humans , Male , Middle Aged , Neurologists , Prospective Studies , Surveys and QuestionnairesABSTRACT
INTRODUCTION: Informal caregivers of patients with Alzheimer's disease (AD) have a poor health-related quality of life (HRQOL). HRQOL is an increasingly common user-focused outcome measure. We have evaluated HRQOL longitudinally in caregivers of AD patients at baseline and at 12 months. METHODS: Ninety-seven patients diagnosed with AD according to the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke, and Alzheimer's Disease and Related Disorders Association) and their 97 respective primary caregivers were included in the study. We analysed the following data at the baseline visit: sociodemographic data of both patients and carers, patients' clinical variables, and data related to the healthcare provided to patients by carers. HRQOL of caregivers was measured with the SF-36 questionnaire at baseline and 12 months later. RESULTS: At 12 months, primary caregivers scored lower in the 8 subscales of the SF-36 questionnaire; differences were statistically significant in all dimensions except for 'physical function' and 'social function'. Baseline scores in our sample were lower than those of the general population. 'Vitality' is the dimension that presented the lowest scores. CONCLUSION: HRQOL in caregivers of patients with Alzheimer's disease deteriorates over time and is poorer than that of the age- and sex-matched general population.
Subject(s)
Alzheimer Disease , Caregivers/psychology , Quality of Life , Aged , Alzheimer Disease/nursing , Female , Humans , Longitudinal Studies , Male , Middle Aged , Surveys and QuestionnairesABSTRACT
Introducción: El estudio de las redes neuronales implicadas en el procesamiento de la música ha recibido menos atención que la dispensada al lenguaje proposicional. Desde hace dos décadas existe un interés creciente en conocer los mecanismos funcionales del cerebro musical y los trastornos que surgen del daño de las estructuras implicadas en la percepción y producción de la música. Desarrollo: Los déficits congénitos y adquiridos del procesamiento musical en cualquiera de sus componentes (percepción, ejecución, memoria musical) se engloban dentro del término genérico amusia. En este trabajo se presenta una revisión selectiva del «estado-del-arte» delos procesos cognitivos y neurales implicados en la música y los diferentes tipos de amusias. Conclusiones: El procesamiento musical depende de una amplia red neural córtico-subcortical distribuida en ambos hemisferios cerebrales y cerebelo. El análisis de sujetos sanos con neuroimagen funcional y de los déficits selectivos en los componentes musicales (p. ej., tono, ritmo, timbre, contorno melódico) en pacientes con amusia mejorarán nuestro conocimiento acerca de los mecanismos implicados en el procesamiento musical y su relación con otros procesos cognitivos (AU)
Introduction: The study of the neural networks involved in music processing has received less attention than work researching the brains language networks. For the last two decades there has been a growing interest in discovering the functional mechanisms of the musical brain and understanding those disorders in which brain regions linked with perception and production of music are damaged Discussion: Congenital and acquired musical deficits in their various forms (perception, execution, music-memory) are grouped together under the generic term amusia. In this selective review we present the cutting edge studies on the cognitive and neural processes implicated in music and the various forms of amusia. Conclusions: Musical processing requires a large cortico-subcortical network which is distributed throughout both cerebral hemispheres and the cerebellum. The analysis of healthy subjects sing functional neuroimaging and examination of selective deficits (e.g., tone, rhythm, timbre, melodic contours) in patients will improve our knowledge of the mechanisms involved in musical processing and the latters relationship with other cognitive processes (AU)
Subject(s)
Humans , Cognition Disorders , Perceptual Disorders , Music , Mental Processes , Functional LateralityABSTRACT
INTRODUCTION: The study of the neural networks involved in music processing has received less attention than work researching the brain's language networks. For the last two decades there has been a growing interest in discovering the functional mechanisms of the musical brain and understanding those disorders in which brain regions linked with perception and production of music are damaged. DISCUSSION: Congenital and acquired musical deficits in their various forms (perception, execution, music-memory) are grouped together under the generic term amusia. In this selective review we present the "cutting edge" studies on the cognitive and neural processes implicated in music and the various forms of amusia. CONCLUSIONS: Musical processing requires a large cortico-subcortical network which is distributed throughout both cerebral hemispheres and the cerebellum. The analysis of healthy subjects using functional neuroimaging and examination of selective deficits (e.g., tone, rhythm, timbre, melodic contours) in patients will improve our knowledge of the mechanisms involved in musical processing and the latter's relationship with other cognitive processes.
Subject(s)
Cognition/physiology , Music Therapy/methods , Music/psychology , Perceptual Disorders/psychology , Adult , Aged , Brain/physiology , Female , Humans , Male , Middle Aged , Models, Psychological , Perceptual Disorders/rehabilitationABSTRACT
The development of immunization strategies to induce strong and multiepitopic T-cell responses against tumour antigens is needed for anti-tumour immunotherapy. However, a common finding after immunization with complex antigens is the preferential induction of immune responses against immunodominant epitopes. In this study, with the aim of inducing multiepitopic responses against several common tumour antigens, we have designed a minigene construct encoding four human leucocyte antigen (HLA)-A2-restricted epitopes belonging to tumour antigens CEA (CEA-691 and CEA-571), MAGE2 (MAGE2-157) and MAGE3 (MAGE3-112), as well as the universal PADRE epitope recognized by T helper lymphocytes. To optimize the activation of immune responses against these epitopes, we have used different antigen formats (short peptides encompassing individual epitopes and DNA plasmids or adenoviral constructs expressing the minigene) in single or combined immunization schedules. A single immunization with either DNA plasmid or recombinant adenovirus induced a monospecific immune response against the immunodominant epitope CEA-571, whereas immunization with the peptide pool induced responses against all epitopes. Combination of peptide priming followed by a boost with the plasmid and the recombinant adenovirus expressing the minigene induced stronger, multi-specific and long-lasting immune responses, overcoming the immunodominance imposed by the main T-cell epitope. Moreover, these combined immunization strategies were able to induce responses that were able to recognize Mel624 HLA-A2+ tumour cells expressing MAGE2. These results suggest that heterologous immunization strategies combining peptides and DNA or recombinant adenoviruses can be useful to broaden the specificity and enhance the efficacy of subunit vaccines.
Subject(s)
Antigens, Neoplasm/immunology , Cancer Vaccines/immunology , Epitopes, T-Lymphocyte , Peptides/immunology , Vaccines, DNA/immunology , Vaccines, Synthetic/immunology , Adenoviridae/genetics , Animals , Carcinoembryonic Antigen/immunology , HLA-A2 Antigen/immunology , Humans , Immunization , Mice , Neoplasm Proteins/immunology , Plasmids , T-Lymphocytes, Cytotoxic/immunologyABSTRACT
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