ABSTRACT
BACKGROUND/AIMS: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms. METHODS: Monocentric study, open-label, randomized design, with two parallel groups receiving Abexol tablets (150 mg/d) or Abexol suspension (75 mg/d) for 8 weeks. Primary efficacy variable (significant improvement in the total score of Gastrointestinal Symptom Rating Scale [GSRS]). Significant reduction in the intensity of the gastrointestinal-symptoms and the reduction in the consumption of antacids are considered secondary efficacy variable. Short form-36 (SF-36) quality of life questiongenonaire was evaluated as collateral variable. Data were analyzed as per intention to treat. RESULTS: A significantly decrease in the overall score of the survey was observed with respect to the baseline level (p < 0.001) of 81.4% in the Abexol suspension group and 77.9% in the Abexol tablets group. At the end of the trial, most gastrointestinal- symptoms disappeared or reduced significantly. The frequency of consumption of neutralizing antacids was low. The significantly improvement in the perception of the state of health obtained in the Abexol is in correspondence with the improvement achieved in some of the components evaluate in the SF-36 questionnaire. Both treatments were safe and well tolerated. CONCLUSION: Abexol suspension showed efficacy and safety similar to Abexol tablets in patients with gastrointestinal symptoms, but using half the dose.
Subject(s)
Antacids , Quality of Life , Animals , Humans , Double-Blind Method , Tablets , Treatment OutcomeABSTRACT
RESUMEN La obstrucción al flujo de salida de la unión esófago-gástrica es un trastorno motor esofágico poco conocido debido a su reciente identificación con el advenimiento de la manometría de alta resolución. Su desconocimiento hace que frecuentemente no sea advertido en el área clínica. Se presenta el caso de un paciente de sexo masculino, de 34 años de edad, que hacía aproximadamente 5 años comenzó a notar de manera esporádica sensación de atoro de los alimentos sólidos a nivel torácico, asociado en ocasiones a vómitos postpandriales tempranos. Esta manifestación se hizo más frecuente hacía un año y medio por lo que acudió al facultativo de su provincia sin conseguir diagnóstico ni mejoría clínica, motivo por el cual fue remitido al Instituto de Gastroenterología. Después de realizar las pruebas rutinarias en el estudio de una disfagia se obtuvo el resultado mediante manometría de alta resolución de una obstrucción al flujo de salida de la unión esófago gástrica. La presentación de este caso puede aportar a los especialistas de medicina interna, nuevos conocimientos para que tengan en cuenta esta entidad en pacientes con disfagia donde no se demuestre causa orgánica. Por lo que el objetivo de este reporte es describir el caso de un paciente con disfagia que presenta una obstrucción al flujo de salida de la unión esófago-gástrica.
ABSTRACT Gastric-esophageal junction outflow obstruction is a poorly understood esophageal motor disorder due to its recent identification with the beginning of high-resolution manometry. His ignorance means that it is frequently not noticed in the clinical area. The case of a 34-years-old male patient is presented, who approximately 5 years ago began to sporadically notice a sensation of clogging of solid foods at the thoracic level, sometimes associated with early postprandial vomiting. This manifestation became more frequent a year and a half ago, so he went to the doctor in his province without obtaining a diagnosis or clinical improvement, that is why he was referred to the Gastroenterology Institute. After performing the routine tests in the dysphagia study, the result was obtained by high resolution manometry of an obstruction to the outflow of the gastric esophagus junction. This case presentation can provide to internal medicine specialists with new knowledge so that they take this entity into account in patients with dysphagia where no organic cause is demonstrated. Therefore, the aim of this report is to describe the case of a patient with dysphagia who presents an obstruction to the outflow of the esophagus-gastric junction.
