Lifetime prevalence of psychiatric comorbidities in patients with bipolar disorder: A systematic review and meta-analysis.

BACKGROUND: Bipolar disorder (BD) is a severe psychiatric disease and part of its burden is related to the high rates of lifetime psychiatric comorbidity (PC), with diagnostic, therapeutic, and prognostic implications. METHODS: Registered in PROSPERO (CRD42021282356). Meta-analyses were performed, searching for relevant papers published from 1993 to 2022 in Medline/PubMed (including E-Pub Ahead of Print), Embase, Cochrane Library (Central), PsycINFO, Scopus, Web of Science and via hand-searching, without language restrictions. 12.698 studies were initially identified, 114 of which were ultimately chosen based on the eligibility criteria. We performed two meta-analyses (prevalence and risk ratio) of mental health conditions among subjects with BD and then conducted a comprehensive examination of moderator effects using multivariable meta-regression models for moderators identified as significant in the univariable analysis. FINDINGS: Overall PC prevalence of at least one disorder was 38.91 % (95 % CI 35.24-42.70) and the most frequent disorders were: anxiety (40.4 % [34.97-46.06]), SUD (30.7 % [23.73-38.73]), ADHD (18.6 % [10.66-30.33]) and Disruptive, impulse-control and conduct disorder (15 % [6.21-31.84). The moderators with higher association with individual prevalences were UN's Human Development Index (HDI), female gender, age, suicide attempt, and age at onset (AAO). INTERPRETATION: It becomes evident that the prevalence of PC among individuals with BD is notably high, surpassing rates observed in the general population. This heightened prevalence persists despite significant heterogeneity across studies. Consequently, it is imperative to redirect clinical focus towards comprehensive mental health assessments, emphasizing personalized and routine screening. Additionally, there is a pressing need for the enhancement of public policies to create a supportive environment for individuals with BD, ensuring better therapeutic conditions and sustained assistance. By addressing these aspects, we can collectively strive towards fostering improved mental health outcomes for individuals with BD.

Low prevalence of contraceptive use among Brazilian women of reproductive age with systemic lupus erythematosus.

This was a cross-sectional study of women of reproductive age with systemic lupus erythematosus (SLE) being treated at Bahiana School Rheumatology Service in Brazil. The study aimed to assess the prevalence of contraceptive counselling and use. An interview was performed, and the results were analysed before and after the SLE diagnosis. Eighty-five women were included; the mean age of the group was 32.98 ± 8.39 years. Before SLE diagnosis, most of the patients had used some contraceptive method; mainly oral contraceptives (54%) or hormone injections (21%). After SLE diagnosis, 53% of patients did not use any contraceptive method. Among the remaining patients who continued using contraceptives, 22% used condoms, 11% used combined oral contraceptives and 7% used hormone injections. Although 62% of the patients regularly visited the gynaecologist, 56% were unaware of which contraceptive method could be used safely. Thus, a better contraceptive counselling of women of a reproductive age should be performed after SLE diagnosis. Impact Statement What is already known on this subject? Women diagnosed with SLE have inadequate counselling about family planning. What the results of this study add? Brazilian women with SLE have a low prevalence of contraceptive use after their diagnosis and are exposed to having high-risk pregnancies. What the implications are of these findings for clinical practice and/or further research? The results we found highlight the importance of continued medical educational programmes and establish questions for further studies in order to investigate the interventions used to improve the contraceptive use for women diagnosed with SLE.

Suicídio e Espiritualidade / Suicide and spirituality

A religiosidade/espiritualidade (R/E) é um tema de grande interesse na atualidade, principalmente no que concerne à sua relação com a saúde mental. De fato, o efeito benéfico dessa associação tem sido descrito com níveis de bem-estar maiores, redução do uso de drogas, menores taxas de depressão e ansiedade, além de se apresentar como um fator protetor ao comportamento suicida (CS). Contudo, os mecanismos que possam explicar esses resultados ainda não foram adequadamente esclarecidos. Da mesma forma, existem muitas dificuldades em transpor esse conhecimento para a prática clínica, sendo este um dos maiores desafios deste campo de pesquisa. Assim, diante da relevância deste tópico, este artigo objetiva fazer uma atualização sobre as conexões entre R/E e CS, visando discutir não só os aspectos positivos, mas também os possíveis elementos negativos envolvidos nessa relação. Para tal, foi realizada uma revisão da literatura com ênfase em artigos publicados nas últimas duas décadas.

The relation between religiosity/spirituality (R/S) and health is a topic of great interest actually, especially regarding mental health. In fact, the beneficial effect of this association has been described with higher levels of well-being, reduction of drug use, lower rates of depression and anxiety, as well as being a protective factor specifically for suicidal behavior (SB). However the mechanisms that may explain these results have not yet been adequately clarified. Likewise, there are still many difficulties in transposing this knowledge into clinical practice, which is the biggest challenge related to this theme. Thus, in view of the relevance of the theme, this article aims to bring an update on the relation between R/S and SB, with an approach not only to the positive aspects, but also about the negative elements involved among them. To this end, we conducted a literature review with emphasis on articles published in the past two decades.

Pulmonary Embolism Mortality in Brazil from 1989 to 2010: Gender and Regional Disparities / Mortalidade por Embolia Pulmonar no Brasil entre 1989 e 2010: Disparidades Regionais e por Gênero

Abstract Background: A significant variation in pulmonary embolism (PE) mortality trends have been documented around the world. We investigated the trends in mortality rate from PE in Brazil over a period of 21 years and its regional and gender differences. Methods: Using a nationwide database of death certificate information we searched for all cases with PE as the underlying cause of death between 1989 and 2010. Population data were obtained from the Brazilian Institute of Geography and Statistics (IBGE). We calculated age-, gender- and region-specific mortality rates for each year, using the 2000 Brazilian population for direct standardization. Results: Over 21 years the age-standardized mortality rate (ASMR) fell 31% from 3.04/100,000 to 2.09/100,000. In every year between 1989 and 2010, the ASMR was higher in women than in men, but both showed a significant declining trend, from 3.10/100,000 to 2.36/100,000 and from 2.94/100,000 to 1.80/100,000, respectively. Although all country regions showed a decline in their ASMR, the largest fall in death rates was concentrated in the highest income regions of the South and Southeast Brazil. The North and Northeast regions, the lowest income areas, showed a less marked fall in death rates and no distinct change in the PE mortality rate in women. Conclusions: Our study showed a reduction in the PE mortality rate over two decades in Brazil. However, significant variation in this trend was observed amongst the five country regions and between genders, pointing to possible disparities in health care access and quality in these groups.

Resumo Fundamento: Uma significativa variação nas tendências de mortalidade por embolia pulmonar (EP) foi documentada em todo o mundo. Investigamos as tendências na taxa de mortalidade por EP no Brasil no período de 21 anos, assim como suas diferenças regionais e de gênero. Métodos: Utilizando uma base de dados nacionais de certificados de óbito, buscamos todos os casos de EP como causa básica de morte entre 1989 e 2010. Dados populacionais foram obtidos no Instituto Brasileiro de Geografia e Estatística. Calculamos as taxas de mortalidade específica por idade, gênero e região para cada ano, usando a população brasileira do ano 2000 para padronização direta. Resultados: Nos 21 anos, a taxa de mortalidade padronizada por idade (TMPI) caiu 31%, passando de 3,04/100.000 para 2,09/100.000. Em cada ano entre 1989 e 2010, a TMPI foi maior nas mulheres do que nos homens, tendo ambos mostrado uma significativa tendência decrescente, de 3,10/100.000 para 2,36/100.000 e de 2,94/100.000 para 1,80/100.000, respectivamente. Embora todas as regiões do país tenham apresentado um declínio em suas taxas de mortalidade padronizada por idade, as maiores quedas concentraram-se nas regiões de mais alta renda do Sul e Sudeste do Brasil. As regiões Norte e Nordeste, que têm as mais baixas rendas, apresentaram uma queda menos marcante nas taxas de mortalidade, sem qualquer alteração na taxa de mortalidade por EP nas mulheres. Conclusões: Nosso estudo mostrou uma redução na taxa de mortalidade por EP nas duas décadas no Brasil. Entretanto, houve uma significativa variação nessa tendência entre as cinco regiões do país e entre gêneros, indicando uma possível disparidade no acesso aos cuidados de saúde e sua qualidade nesses grupos.

Pulmonary Embolism Mortality in Brazil from 1989 to 2010: Gender and Regional Disparities.

BACKGROUND: A significant variation in pulmonary embolism (PE) mortality trends have been documented around the world. We investigated the trends in mortality rate from PE in Brazil over a period of 21 years and its regional and gender differences. METHODS: Using a nationwide database of death certificate information we searched for all cases with PE as the underlying cause of death between 1989 and 2010. Population data were obtained from the Brazilian Institute of Geography and Statistics (IBGE). We calculated age-, gender- and region-specific mortality rates for each year, using the 2000 Brazilian population for direct standardization. RESULTS: Over 21 years the age-standardized mortality rate (ASMR) fell 31% from 3.04/100,000 to 2.09/100,000. In every year between 1989 and 2010, the ASMR was higher in women than in men, but both showed a significant declining trend, from 3.10/100,000 to 2.36/100,000 and from 2.94/100,000 to 1.80/100,000, respectively. Although all country regions showed a decline in their ASMR, the largest fall in death rates was concentrated in the highest income regions of the South and Southeast Brazil. The North and Northeast regions, the lowest income areas, showed a less marked fall in death rates and no distinct change in the PE mortality rate in women. CONCLUSIONS: Our study showed a reduction in the PE mortality rate over two decades in Brazil. However, significant variation in this trend was observed amongst the five country regions and between genders, pointing to possible disparities in health care access and quality in these groups.

Infections in patients with diabetes mellitus: A review of pathogenesis.

In general, infectious diseases are more frequent and/or serious in patients with diabetes mellitus, which potentially increases their morbimortality. The greater frequency of infections in diabetic patients is caused by the hyperglycemic environment that favors immune dysfunction (e.g., damage to the neutrophil function, depression of the antioxidant system, and humoral immunity), micro- and macro-angiopathies, neuropathy, decrease in the antibacterial activity of urine, gastrointestinal and urinary dysmotility, and greater number of medical interventions in these patients. The infections affect all organs and systems. Some of these problems are seen mostly in diabetic people, such as foot infections, malignant external otitis, rhinocerebral mucormycosis, and gangrenous cholecystitis. In addition to the increased morbidity, infectious processes may be the first manifestation of diabetes mellitus or the precipitating factors for complications inherent to the disease, such as diabetic ketoacidosis and hypoglycemia. Immunization with anti-pneumococcal and influenza vaccines is recommended to reduce hospitalizations, deaths, and medical expenses.

Implantação de grupo de estudos em diabetes mellitus em uma unidade de saúde da família do município de Salvador-Bahia

O Diabetes Mellitus (DM) é uma doença decorrente de múltiplos fatores, tanto genéticos, quanto clínicos e, atualmente, é considerado um problema de saúde pública. O bom controle metabólico previne o surgimento ou retarda a progressão de suas complicações crônicas e o processo de educação em saúde está relacionado à maior autonomia e entendimento da doença pelo paciente, o que promove maior adesão ao tratamento farmacológico e não farmacológico. Este projeto visa instituir um grupo de estudos em Diabetes Mellitus em uma USF em Salvador-BA. Para alcançar esse objetivo, as reuniões semanais das equipes serão utilizadas para discutir estratégias de implantação do grupo e, posteriormente, ocorrerão reuniões com a participação de profissionais e pacientes. Ao final, espera-se que a equipe encontre-se capacitada para atender integralmente o paciente com DM e que a população apresente maior adesão ao tratamento farmacológico e não farmacológico do Diabetes Mellitus, além de melhor controle metabólico desta patologia.