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1.
AJNR Am J Neuroradiol ; 39(5): 942-948, 2018 05.
Article in English | MEDLINE | ID: mdl-29519789

ABSTRACT

BACKGROUND AND PURPOSE: Congenital aqueductal stenosis is a common cause of prenatal ventriculomegaly. An accurate diagnosis provides prognostic information and may guide obstetric management. The purpose of this study was to identify specific anatomic findings on prenatal MR imaging that can be used as predictors of congenital aqueductal stenosis. MATERIALS AND METHODS: Prenatal and postnatal MRIs of fetuses referred to our institution for ventriculomegaly between June 2008 and August 2015 were reviewed. Imaging findings in postnatally confirmed congenital aqueductal stenosis (disease group) were compared with those of ventriculomegaly cases from other causes (control group). Univariate analysis was performed using the Fisher exact test and the Wilcoxon rank test, and multivariate analysis, via the random forest method. RESULTS: Forty-three cases of ventriculomegaly had a confirmed postnatal diagnosis of congenital aqueductal stenosis. Thirty-two ventriculomegaly cases negative for congenital aqueductal stenosis were included in the control group. Dominant findings associated with an accurate prenatal diagnosis of congenital aqueductal stenosis on multivariate analysis included the following: enlarged inferior third ventricular recesses, enlargement of the lateral ventricles and third ventricle, and an abnormal corpus callosum. Findings that significantly increase the probability of congenital aqueductal stenosis (high positive predictive value) included the following: enlarged third ventricular recesses, aqueduct funneling, hemorrhage in the cerebral aqueduct, ventricular diverticulum, rhombencephalosynapsis, and dystroglycanopathy-related cerebellar dysplasia. CONCLUSIONS: Our study identified specific characteristics on fetal MR imaging that can be used as predictors of the diagnosis of congenital aqueductal stenosis. Most of these findings are secondary to the obstructive nature of the resulting hydrocephalus. Common associated malformations such as rhombencephalosynapsis and dystroglycanopathies should also increase the suspicion of congenital aqueductal stenosis when present with ventriculomegaly.


Subject(s)
Hydrocephalus/congenital , Hydrocephalus/diagnostic imaging , Prenatal Diagnosis/methods , Cerebral Aqueduct/abnormalities , Cerebral Aqueduct/diagnostic imaging , Female , Fetus/diagnostic imaging , Humans , Magnetic Resonance Imaging , Male , Pregnancy
2.
Ultrasound Obstet Gynecol ; 45(6): 683-8, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25158239

ABSTRACT

OBJECTIVE: To evaluate the impact of the presence of a congenital heart anomaly (CHA) and its potential contribution to morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). METHODS: In this retrospective cohort study, prenatal and postnatal data of all newborns diagnosed with CDH between January 2004 and December 2012 in a single center were reviewed. Cases were classified into two groups: those with 'isolated' CDH and those with both CDH and CHA. Patients with CHA were further subclassified into those with a major or minor CHA based on the Risk Adjustment for Congenital Heart Surgery-1 (RACHS-1), and the Society of Thoracic Surgeons-European Association for Cardiothoracic Surgery (STS-EACTS) scoring systems. Patients with associated non-cardiac anomalies, including 'syndromic cases', were excluded from the analysis. Primary and secondary outcomes were survival up to 1 year of age and a need for extracorporeal membrane oxygenation (ECMO), respectively. RESULTS: Of the 180 infants with CDH, 41 were excluded because of the presence of non-cardiac associated anomalies, 118 had isolated CDH and 21 had CDH with CHA (16 with minor and five with major CHA). Receiver-operating characteristics curve analysis demonstrated that the best cut-off for survival was when the score for CHA was ≤ 2 for both RACHS-1 (area under the curve (AUC), 0.74 (P = 0.04); sensitivity, 80.0%; specificity, 87.5%) and STS-EACTS (AUC, 0.83 (P = 0.03); sensitivity, 100%; specificity, 87.5%). Survival rate at 1 year was significantly lower in those with CHD and a major CHA (40.0%; P = 0.04) than in those with isolated CDH (77.1%) and those with CDH and a minor CHA (81.3%). We found no significant differences among the groups with regard to the need for ECMO. CONCLUSIONS: In general, a milder form of CHA does not appear to have a negative impact on the survival of infants with CDH. However, mortality appears to be significantly higher in infants with CDH and a major form of CHA. The scoring systems appear to be useful as predictors for classifying the effects of CHA in this population of patients.


Subject(s)
Heart Defects, Congenital/mortality , Hernias, Diaphragmatic, Congenital/mortality , Extracorporeal Membrane Oxygenation/statistics & numerical data , Heart Defects, Congenital/classification , Heart Defects, Congenital/complications , Hernias, Diaphragmatic, Congenital/complications , Humans , Infant , Infant, Newborn , Kaplan-Meier Estimate , ROC Curve , Retrospective Studies , Sensitivity and Specificity , Survival Rate
3.
Ultrasound Obstet Gynecol ; 46(2): 150-4, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25366655

ABSTRACT

OBJECTIVES: To describe a method of quantifying the amount of liver herniation in fetuses with isolated congenital diaphragmatic hernia (CDH) using two-dimensional ultrasonography and to correlate this finding with neonatal outcome. METHODS: Ultrasound images obtained from 77 consecutive fetuses that presented with isolated CDH between January 2004 and July 2012 were reviewed. Liver herniation and thoracic area were measured in a cross-sectional plane of the fetal chest at the level of the four-chamber view of the heart (the same section as is used to measure the lung area-to-head circumference ratio) and the ultrasound-derived liver-to-thoracic area ratio (US-LiTR) was calculated by dividing the liver herniation area by the thoracic area. Receiver-operating characteristics (ROC) curve analysis was used to evaluate the performance of US-LiTR in predicting neonatal outcome (survival to 6 months after delivery and need for extracorporeal membrane oxygenation (ECMO)). In addition, the US-LiTR was compared with the magnetic resonance imaging (MRI)-derived volume ratio (MRI-LiTR) and percentage of liver herniation (MRI-%LH). RESULTS: The overall neonatal mortality in the 77 cases with isolated CDH was 20.8% (16/77). ECMO was needed in 35.5% (27/76) of the newborns, with a survival rate of 52%. The US-LiTR was associated statistically with mortality (P < 0.01) and with the need for ECMO (P < 0.01). Good correlations were observed between US-LiTR and MRI-LiTR (r = 0.87; P < 0.001) and between US-LiTR and MRI-%LH (r = 0.90; P < 0.001). Based on ROC curve analysis, all three parameters had similar accuracy in predicting mortality (US-LiTR: area under the ROC curve (AUC), 0.78 (95% CI, 0.65-0.92), P < 0.01; MRI-LiTR: AUC, 0.77 (95% CI, 0.63-0.90), P < 0.01; MRI-%LH: AUC, 0.79 (95% CI, 0.65-0.92), P < 0.01, respectively) as well as the need for ECMO (US-LiTR: AUC, 0.72 (95% CI, 0.60-0.84), P < 0.01; MRI-LiTR: AUC, 0.73 (95% CI, 0.60-0.88), P < 0.01; MRI-%LH: AUC, 0.77 (95% CI, 0.64-0.89), P < 0.01, respectively). CONCLUSIONS: Two-dimensional ultrasound measurement of the amount of liver herniation in fetuses with isolated CDH is feasible and demonstrates a predictive accuracy for neonatal outcome similar to that of MRI.


Subject(s)
Fetal Diseases/diagnostic imaging , Fetal Diseases/pathology , Hernias, Diaphragmatic, Congenital/diagnostic imaging , Liver Diseases/diagnostic imaging , Liver Diseases/embryology , Liver Diseases/pathology , Ultrasonography, Prenatal/methods , Adult , Cohort Studies , Extracorporeal Membrane Oxygenation/methods , Female , Fetal Diseases/therapy , Hernias, Diaphragmatic, Congenital/pathology , Hernias, Diaphragmatic, Congenital/surgery , Hernias, Diaphragmatic, Congenital/therapy , Humans , Infant, Newborn , Liver Diseases/therapy , Magnetic Resonance Imaging/methods , Predictive Value of Tests , Pregnancy , Retrospective Studies
4.
Ultrasound Obstet Gynecol ; 43(6): 662-9, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24127326

ABSTRACT

OBJECTIVE: To determine associations between fetal lung and liver herniation volumes measured by magnetic resonance imaging (MRI) and mortality/need for extracorporeal membrane oxygenation (ECMO) in cases of isolated congenital diaphragmatic hernia (CDH). A secondary objective was to compare prenatal MRI parameters with two-dimensional ultrasound lung measurements. METHODS: A retrospective review of medical records of all fetuses with isolated CDH evaluated between January 2004 and July 2012 was performed. The following MRI parameters were measured at 20-32 weeks: observed/expected total fetal lung volume (o/e-TLV), predicted pulmonary volume (PPV), percentage of liver herniated into the fetal thorax (%LH) and the liver/thoracic volume ratio (LiTR). These were compared with the ultrasound-determined lung-to-head ratio (LHR) and the observed/expected LHR (o/e-LHR) in the same cohort. The predictive value of MRI and ultrasound parameters for mortality and the need for ECMO was evaluated by univariate, multivariate and factor analysis and by receiver-operating characteristics curves. RESULTS: Eighty fetuses with isolated CDH were evaluated. Overall mortality was 18/80 (22.5%). Two newborns died a few hours after birth. ECMO was performed in 29/78 (37.2%) newborns, with a survival rate of 48.3% (14/29). The side of the diaphragmatic defect was not associated with mortality (P = 0.99) or the need for ECMO (P = 0.48). Good correlation was observed among o/e-TLV, PPV, LHR and o/e-LHR as well as between %LH and LiTR (r = 0.89; P < 0.01); however, fetal lung measurements and measures of liver herniation were not correlated (all P > 0.05). All parameters were statistically associated with mortality or the need for ECMO. The best combination of measurements to predict mortality was o/e-TLV and %LH, with 83% accuracy. CONCLUSION: Mortality and the need for ECMO in neonates with isolated CDH can be best predicted using a combination of MRI o/e-TLV and %LH.


Subject(s)
Fetal Diseases/pathology , Hernias, Diaphragmatic, Congenital/pathology , Liver Diseases/pathology , Lung/embryology , Adult , Extracorporeal Membrane Oxygenation , Female , Head/embryology , Humans , Liver Diseases/embryology , Lung Volume Measurements/methods , Magnetic Resonance Imaging , Pregnancy , ROC Curve , Reproducibility of Results , Retrospective Studies , Ultrasonography, Prenatal
5.
Pediatr Surg Int ; 29(5): 437-43, 2013 May.
Article in English | MEDLINE | ID: mdl-23411614

ABSTRACT

PURPOSE: Our institution routinely utilizes needle core biopsy (NCB), instead of fine needle aspiration, in the evaluation of pediatric thyroid nodules. This practice initially arose from limited cytopathology services in our hospital. Given the lack of information regarding the utility of NCB in diagnosing pediatric thyroid neoplasms, we set out to review our institution's experience with this technique. METHODS: We performed a single institution retrospective chart review of all children who underwent thyroidectomy for primary thyroid pathology. RESULTS: Seventy-four patients, with a mean age of 12.9 ± 4.5 (SD) years, underwent partial or total thyroidectomy between 2002 and 2010. Seven of these patients had medically refractive hyperthyroidism. The remaining 67 patients had one or more thyroid nodules as identified by ultrasound. 24 (36 %) of these cases were malignant on final pathology. 14 (58 %) of the malignant cases were papillary thyroid carcinoma. 46 of the thyroid nodule cases underwent pre-operative NCB. Biopsy results for these patients were non-diagnostic in 6 (13 %), benign in 11 (24 %), atypical in 17 (37 %), and malignant in 12 (26 %). There were no complications arising from NCB. Sensitivity of NCB for diagnosing papillary carcinoma (PC) and follicular neoplasm was calculated at 0.88 (0.47-1.0, 95 % CI) and 0.84 (0.60-0.97, 95 % CI), respectively. Of the 28 patients not undergoing preoperative NCB, 12 underwent hemithyroidectomy, with one patient (8 %) requiring completion thyroidectomy for PC. Overall, the sensitivity of NCB in diagnosing PC and follicular thyroid neoplasms was 0.85 (0.55-0.99, 95 % CI), while the specificity was 0.63 (0.42-0.82, 95 % CI). CONCLUSIONS: Needle core biopsy appears to have a low rate of associated complications, and its sensitivity for diagnosing PC and follicular neoplasm is comparable to what has been reported for fine needle aspiration biopsy in a similar patient population.


Subject(s)
Thyroid Gland/pathology , Thyroid Neoplasms/pathology , Adolescent , Biopsy, Fine-Needle , Biopsy, Large-Core Needle , Child , Female , Humans , Male , Retrospective Studies , Sensitivity and Specificity , Thyroid Neoplasms/surgery , Thyroidectomy
6.
Pediatr Cardiol ; 28(3): 172-5, 2007.
Article in English | MEDLINE | ID: mdl-17375352

ABSTRACT

We report two cases of pentalogy of Cantrell diagnosed in utero using a combination of fetal echocardiography and magnetic resonance imaging. The cardiac component consisted of tetralogy of Fallot in the first fetus and ventricular septal defect in the second fetus. Whereas fetal echocardiography allowed accurate delineation of the cardiac anatomy, prenatal magnetic resonance imaging allowed clearer delineation of the extent of the thoracic and abdominal wall defects. Fetal magnetic resonance imaging in conjunction with prenatal echocardiography allows optimal assessment of the fetus with ectopia cordis, which has significant implications from the standpoint of preoperative planning and providing prognostic information. This report represents the first description of applying magnetic resonance imaging in combination with echocardiography toward a better understanding of this clinical entity in the fetus.


Subject(s)
Abnormalities, Multiple/diagnostic imaging , Heart Septal Defects, Ventricular/diagnostic imaging , Tetralogy of Fallot/diagnostic imaging , Adult , Echocardiography , Female , Hernia, Diaphragmatic/diagnostic imaging , Hernia, Umbilical/diagnostic imaging , Humans , Magnetic Resonance Imaging , Male , Pregnancy , Ultrasonography, Prenatal/methods , alpha-Fetoproteins/analysis
8.
AJR Am J Roentgenol ; 156(1): 59-62, 1991 Jan.
Article in English | MEDLINE | ID: mdl-1898571

ABSTRACT

We conducted a telephone interview of all 207 accredited diagnostic radiology residency training programs listed in the American Medical Association's Directory of Graduate Medical Education Programs. Resident training in mammography was offered in 206 programs, and 35% of the programs had initiated this training within the past 3 years. Residents had an assigned block of time to do mammography in 84% of the programs. Of the 206 programs, 40% had rotations devoted exclusively to mammography, with 82% of the exclusive rotations lasting from 4 to 8 weeks. Residents were performing localization procedures in 91% of the programs and dictating cases in 81%. A distinction was made between screening and diagnostic examinations by 35% of the training institutions, at least in terms of the fee for the examination. Radiologists who devoted at least half of their practice to mammography taught in 52% of the programs. The American College of Radiology has granted accreditation in mammography to 29% of the programs. Although almost all accredited residency training programs offer training in mammography, there are some deficiencies in this training. More residents need to gain the experience of dictating mammography reports and need to learn about the distinctions between screening and diagnostic mammography. Despite the anticipated deluge of screening examinations in the next decade, there were only 17 fellowships that included at least 6 months of mammography identified in 15 (7%) of the institutions; only 11 of these were full-time 1-year breast imaging fellowships.


Subject(s)
Curriculum , Internship and Residency , Mammography , United States
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