Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Nat Prod Res ; 36(4): 999-1003, 2022 Feb.
Article in English | MEDLINE | ID: mdl-33146027

ABSTRACT

The present work describes the acetylcholinesterase inhibitory activity of Ocotea pomaderroides extracts besides the chemical composition of chromatographic fractions. The hexane, dichloromethane and ethyl acetate extract soluble fractions showed high Electrophorus electricus acetylcholinesterase (EelAChE) inhibition (92.18, 71.86 and 74.25%, respectively) while the butanolic and aqueous extracts showed moderate to low activities (44.48 and 20.74%, respectively). The high-performance liquid chromatography coupled with electrospray ionization multiple-stage mass spectrometry (HPLC-ESI-MSn) analysis led to the identification of the alkaloids and flavonol glycoside derivatives present in these extracts. The binding profile of the alkaloids and their atomic effect on 3D structure of Electrophorus electricus AchE (EelAChE) were assessed with molecular modeling.


Subject(s)
Cholinesterase Inhibitors/pharmacology , Ocotea , Plant Extracts , Acetylcholinesterase/metabolism , Chromatography, High Pressure Liquid , Ocotea/chemistry , Plant Extracts/chemistry , Plant Extracts/pharmacology , Spectrometry, Mass, Electrospray Ionization , Tandem Mass Spectrometry
2.
Nat Prod Res ; 28(5): 333-6, 2014.
Article in English | MEDLINE | ID: mdl-24219406

ABSTRACT

Aerial parts of Microlicia hatschbachii were extracted with hexane, and the extract was evaluated for antimicrobial activity by a broth dilution method. After phytochemical procedures: GC-MS identified aliphatic alkanes, carboxylic acids and methyl esters of long-chain fatty acids; and two diterpenoids [labd-8(17)-en-15-oic acid and labd-8(17),13-dien-15-oic acid] were identified by (1)H and (13)C NMR. The antimicrobial activity of the hexane extract could be attributed to the presence of labdanes. This identification is the first reported occurrence of labdane diterpenes in the Melastomataceae family.


Subject(s)
Anti-Infective Agents/isolation & purification , Anti-Infective Agents/pharmacology , Diterpenes/isolation & purification , Diterpenes/pharmacology , Fatty Acids/isolation & purification , Fatty Acids/pharmacology , Melastomataceae/chemistry , Anti-Infective Agents/chemistry , Diterpenes/chemistry , Fatty Acids/chemistry , Gas Chromatography-Mass Spectrometry , Hexanes/chemistry , Microbial Sensitivity Tests , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular
SELECTION OF CITATIONS
SEARCH DETAIL
...