ABSTRACT
We undertook an association analysis between the ile50val, glu375ala, cys406arg, and ser761pro polymorphisms of the IL-4Ralpha gene and atopic asthma, total IgE levels and IL-4 serum levels in a population from western Mexico. We found that the ser761pro polymorphism was monomorphic for ser761, while there was no association between any of the other polymorphisms and the three phenotypes analysed.
Subject(s)
Asthma/genetics , Polymorphism, Genetic , Receptors, Interleukin-4/genetics , Amino Acid Substitution , Asthma/epidemiology , Genetic Predisposition to Disease , Heterozygote , Humans , Immunoglobulin E/blood , Interleukin-4/blood , Mexico/epidemiologyABSTRACT
The clinical files were reviewed of eight pediatric patients who died between 1976 and 1990, having the pathological diagnosis of aspergillosis. During the clinical evolution seven displayed malnutrition and respiratory symptomatology, four had slow evolving fever and oral candidiasis. The image in all the chest X-Rays was opaque. In the laboratory four had leukopenia, lymphopenia and neutropenia: two with a positive culture of Aspergillus. Five received four to eight different antibiotics during the last clinical evolution. All showed a combination of diverse forms of aspergillosis, all with the invasive form, five with the disseminated form, three bronchopulmonary allergic and one with aspergilloma. All had invasion of the respiratory system. Septicemia had the cause of death in four and three was direct relation with Aspergillosis.
Subject(s)
Aspergillosis, Allergic Bronchopulmonary/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Retrospective StudiesABSTRACT
We report 30 patients with exogenous lipoid pneumonia due to vegetal oil. This was employed in most of the cases during the first month of life for digestive tube symptomatology; clinical manifestations began three months following administrations, as a pneumonia or bronchopneumonia with a respiratory distress syndrome of variable severity. 60% of the thorax x-ray studies were abnormal, the main finding was opacity. One patient has alterations of the mechanics of deglutition; seven had gastroesophageal reflux. Arterial gasometry showed hypoxaemia and increase of alveolo-arterial gradient of oxygen in all. Ten patients died and all the survivors were reevaluated in september, 1988; 18 had normal physical findings. Thorax x-ray studies in 13 patients had right reticulate infiltration and 6 right apical opacity; ECG showed right ventricular hypertrophy in 3. Perfusion pulmonary gamagram with technetium 99 was abnormal in 5. Gastroesophageal reflux was evident in 2. Five were under treatment for several causes. Diagnosis and treatment is discussed.
Subject(s)
Plant Oils/adverse effects , Pneumonia, Aspiration/chemically induced , Pneumonia, Lipid/chemically induced , Female , Humans , Infant , Infant, Newborn , Male , Pneumonia, Lipid/classification , Pneumonia, Lipid/diagnostic imaging , Pneumonia, Lipid/pathology , Pneumonia, Lipid/physiopathology , RadiographyABSTRACT
We report a 15-year-old male with bronchial asthma since five years old, unresponsive to treatment; at age 12 a diagnosis of pulmonary tuberculosis was made and treated with several drugs. He was referred to our hospital because of hemoptysis. A diagnosis of aspergillosis in the aspergilloma form was made; after, a left upper lobectomy showed the invasive form; later he presented recurrent obstructive respiratory problems, secondary to the allergic form. Serum IgE was elevated, lowering after treatment with corticoids; simultaneously he had clinical improvement. Treatment was discontinued when clinically asymptomatic and serum IgE was normal. Diagnostic route and treatment are discussed.
