[Quality of life and mortality of patients in intensive care. Indices of quality of life]. / Calidad de vida y mortalidad a largo plazo de pacientes en medicina intensiva. Indice de calidad de vida (ICV).

INTRODUCTION: At present there is no single practical standardized scale for measuring quality of life (QL). Any proposal should include the patient's physical impairment, level of independence, and subjective perception of happiness. We combined three previously published scales to define a quality of life index (QLI) that we propose as a standard quantitative instrument. The applicability and usefulness of QLI for the measurement of the level of deterioration of patients after admission to an intensive care unit (ICU) was examined. We prospectively evaluated QL before patient admission to determine if it influences mortality, as well as long-term changes in the QL and the factors conditioning te deterioration of patients released from the UCI as evaluated by QL indicators. MATERIAL AND METHODS: To calculate QLI, we combined the Karnofsky scale, daily life activities index, and the perception of quality of life scale. The resulting percentage (QLI) was used to evaluate 536 patients after admission to the ICU and 6 and 12 months after release. QLI was compared with the severity of disease (Apache II), probability of death (MPM), diagnostic group, and socioeconomic variables. RESULTS: Using multivariate methods, four significant variables related with mortality were identified: Apache II--MPM, duration of the stay in the unit, age, and QLI. Our analysis of long-term deterioration showed that advanced age, high QLI before admission, and the patient's diagnostic group explained the degree of deterioration. DISCUSSION: QLI was a useful instrument for obtaining a quantitative estimate of the QL of critically ill patients.

[Hospital utilization for acute problems of the elderly. Catalonia, 1982-1990]. / La utilización de los hospitales de agudos por los ancianos. Cataluña, 1982-1990.

OBJECTIVE: Analyse the total and causal hospital utilization in Catalonia from 1982 to 1990 for the elderly. METHODS: Hospital admissions and the length of stay will be analysed using direct adjusted rates, age specific rates, percentage variation and the corresponding confidence intervals and significance tests. RESULTS: In population older than 65, male population have a greater hospital utilization and there is an increase in usage of hospitals with age. Sex differences are stressed among the elderly that in general population. Circulatory system diseases are the principal cause of admission in acute hospitals for the elderly of both sexes. CONCLUSIONS: Men and old people make greater hospital utilization. Circulatory system diseases comprise the major part of admissions in acute hospitals, even though other causes are gaining importance, especially mental disorders.

A comparison of severity of illness scoring systems for intensive care unit patients: results of a multicenter, multinational study. The European/North American Severity Study Group.

OBJECTIVE: To compare the performance of three severity of illness scoring systems used commonly for intensive care unit (ICU) patients in a large international data set. The systems analyzed were versions II and III of the Acute Physiology and Chronic Health Evaluation (APACHE) system, versions I and II of the Simplified Acute Physiology Score (SAPS), and versions I and II of the Mortality Probability Model (MPM), computed at admission and after 24 hrs in the ICU. DESIGN: A multicenter, multinational cohort study. SETTING: One hundred thirty-seven ICUs in 12 European and North American countries. PATIENTS: During a 3-month period, 14,745 patients were consecutively admitted to 137 ICUs enrolled in the study. INTERVENTIONS: Collection of information necessary to compute the APACHE II and APACHE III scores, SAPS I and SAPS II, and MPM I and MPM II scores. Patients were followed until hospital discharges. Statistical comparison, including indices of calibration (goodness-of-fit) and discrimination (area under the receiver operating characteristic curve). MEASUREMENTS AND MAIN RESULTS: Despite having acceptable receiver operating characteristic areas, the older versions of the systems analyzed (APACHE II, SAPS, and MPM I computed at admission-MPM I computed after 24 hrs in the ICU) demonstrated poor calibration for the whole database. The new versions of the systems (SAPS II and MPM II) were superior to their older counterparts. This superiority is reflected by larger receiver operating characteristic areas and better fit. The APACHE III system improved its receiver operating characteristic area compared with the APACHE II system, which showed the best fit of the old systems analyzed. CONCLUSIONS: The new versions of the severity systems analyzed (APACHE III, SAPS II, MPM II) perform better than their older counterparts (APACHE II, SAPS I, and MPM I). APACHE II, SAPS II, and MPM II show good discrimination and calibration in this international database.

Fat embolism syndrome and pulmonary microvascular cytology.

Pulmonary microvascular cytology consists of analysis of capillary blood sampled while a Swan-Ganz catheter is in the wedge position. This technique has proved to be useful in the diagnosis of lymphangitic spread of carcinoma in the lungs and there are case reports of their use in amniotic fluid embolism. Its usefulness in diagnosing fat embolism syndrome has been shown only rarely. We report a new case in which pulmonary microvascular cytologic study allowed a definite diagnosis of fat embolism syndrome. We suggest obtaining routinely samples of capillary blood when a pulmonary catheter is in place and fat embolism is suspected on a clinical basis.

[Malignant Mediterranean boutonneuse fever. Septic shock of unknown origin?]. / Fiebre botonosa mediterránea maligna. Shock séptico de origen desconocido?

Mediterranean Botonous Fever (MBF) is an infectious disease which provokes multisystemic vasculitis due to endothelial proliferation of rickettsia conorii. Its incidence, in our environment, has greatly increased during the last years being endemic in many large cities and their surrounding suburbs. In some cases its evolution is specially malignant resulting in septic shock, adult respiratory distress syndrome, and multiorgan failure. The purpose of this communication is to present a new case of malignant MBF with a bad evolution factor which has not been previously referred to, which is the persistence of vector ticks in the inoculation spot.

Mortality prediction models in intensive care: acute physiology and chronic health evaluation II and mortality prediction model compared.

OBJECTIVE: To compare the Acute Physiology and Chronic Health Evaluation (APACHE II) score with the Mortality Prediction Model (MPM). DESIGN: A prospective study. SETTING: A nine-bed ICU in a 300-bed, nonteaching secondary hospital. PATIENTS: Three hundred thirty-two consecutive, unselected adults. MEASUREMENTS AND MAIN RESULTS: We found a good correlation between APACHE II and MPM; their performance expressed as area under the receiver operating characteristics curve was nearly the same. Goodness-of-fit between observed and expected occurrences was better for APACHE II than for admission MPM, which overestimated deaths. Because we evaluate patients early, often in the Emergency Department, we felt that a "lead-time bias" could explain this discrepancy. Reevaluation after initial stabilization improved the performance of the MPM model to the level of APACHE II. CONCLUSIONS: Our investigation indicates that both APACHE II and MPM are good predictors of hospital outcome in our population, but the level of intensive care services received before conventional ICU admission modifies accuracy of predictive models. In any study of outcome using comparative studies of classification systems, confounding biases should be measured.