Shifts in Key Time Points and Strategies for a Multisegment Motor Task in Healthy Aging Subjects.

In this study, we compared key temporal points in the whole body pointing movement of healthy aging and young subjects. During this movement, subject leans forward from a standing position to reach a target. As it involves forward inclination of the trunk, the movement creates a risk for falling. We examined two strategic time points during the task-first, the crossover point where the velocity of the center of mass (CoM) in the vertical dimension outstripped the velocity in the anteroposterior dimension and secondly, the time to peak of the CoM velocity profile. Transitions to stabilizing postures occur at these time points. They both occurred earlier in aging subjects. The crossover point also showed adjustments with target distance in aging subjects, while this was not observed in younger subjects. The shifts in these key time points could not be attributed to differences in movement duration between the two groups. Investigation with an optimal control model showed that the temporal adjustment as a function of target distance in the healthy aging subjects fits into a strategy that emphasized equilibrium maintenance rather than absolute work as a control strategy.

Analysis of the impact of a cognitive task on the posture of elderly subjects with depression compared with healthy elderly subjects.

OBJECTIVE: While previous studies have demonstrated that depressive elderly subjects (DES) experience difficulties in the processing of simultaneous cognitive tasks, few have examined the coupling of cognitive tasks with seemingly 'automatic' tasks, such as standing upright. Current patient management focuses on pharmacological treatments and cognitive-behavioral therapies. METHODS: Healthy elderly (HES) and non-treated DES were included. Postural sway in DES was compared with that in HES while in single-task and dual-task conditions. The single-task consisted of standing upright. For the dual-task, the subjects recalled various items from memory or counted while standing upright. Postural sway was evaluated by computing the center of pressure (CoP) area and path length. RESULTS: DES showed greater postural sway than HES in all conditions. The HES showed a greater CoP area in the dual-task than in the single-task conditions. In DES, the CoP area in the single-task condition was similar to that in the dual-task condition. CONCLUSIONS: The greater postural sway observed in DES may be a cause of a greater risk of falls. We showed that even seemingly automatic tasks, such as maintaining an upright posture, are affected by depression. SIGNIFICANCE: These results are important for the management of DES.

Voluntary Imitation in Alzheimer's Disease Patients.

Although Alzheimer's disease (AD) primarily manifests as cognitive deficits, the implicit sensorimotor processes that underlie social interactions, such as automatic imitation, seem to be preserved in mild and moderate stages of the disease, as is the ability to communicate with other persons. Nevertheless, when AD patients face more challenging tasks, which do not rely on automatic processes but on explicit voluntary mechanisms and require the patient to pay attention to external events, the cognitive deficits resulting from the disease might negatively affect patients' behavior. The aim of the present study was to investigate whether voluntary motor imitation, i.e., a volitional mechanism that involves observing another person's action and translating this perception into one's own action, was affected in patients with AD. Further, we tested whether this ability was modulated by the nature of the observed stimulus by comparing the ability to reproduce the kinematic features of a human demonstrator with that of a computerized-stimulus. AD patients showed an intact ability to reproduce the velocity of the observed movements, particularly when the stimulus was a human agent. This result suggests that high-level cognitive processes involved in voluntary imitation might be preserved in mild and moderate stages of AD and that voluntary imitation abilities might benefit from the implicit interpersonal communication established between the patient and the human demonstrator.

Alterations with movement duration in the kinematics of a whole body pointing movement.

Our aim was to investigate how the organization of a whole body movement is altered when movement duration (MD) is varied. Subjects performed the same whole body pointing movement over long, normal and short MDs. The kinematic trajectories were then analyzed on a normalized time base. A principal components analysis (PCA) revealed that the degree of coordination between the elevation angles of the body did not change with MD. This lack of significant differences in the coordination was interesting given that small spatial and temporal differences were observed in the individual kinematic trajectories. They were revealed by studying the trajectories of the elevation angles, joint markers and center of mass. The elevation angle excursions displayed modifications primarily in their spatial characteristics. These alterations were more marked for the short rather than long duration movements. The temporal characteristics of the elevation angles as measured by the time to peak of angular velocity were not modified in the same fashion hence displaying a dissociation in the tuning of the spatial and temporal aspects of the elevation angles. Modifications in the temporal characteristics of the movement were also studied by examining the velocity profiles of the joint markers. Interestingly, unlike the disordered nature of this variable for the elevation angles, the time to peak velocity was neatly ordered as a function of MD for the joint markers - It arrived first for the short duration movements, followed by those of the normal and finally long duration movements. Despite the modifications observed in the kinematic trajectories, a PCA with the elevation angle excursions at different MDs revealed that two principal components were sufficient to account for nearly all the variance in the data. Our results suggest that although similar, the kinematic trajectories at different MDs are not achieved by a simple time scaling.