Genetic variation in brain-derived neurotrophic factor and human fear conditioning.

Brain-derived neurotrophic factor (BDNF) has been implicated in hippocampal-dependent learning processes, and carriers of the Met allele of the Val66Met BDNF genotype are characterized by reduced hippocampal structure and function. Recent nonhuman animal work suggests that BDNF is also crucial for amygdala-dependent associative learning. The present study sought to examine fear conditioning as a function of the BDNF polymorphism. Fifty-seven participants were genotyped for the BDNF polymorphism and took part in a differential-conditioning paradigm. Participants were shocked following a particular conditioned stimulus (CS+) and were also presented with stimuli that ranged in perceptual similarity to the CS+ (20, 40 or 60% smaller or larger than the CS+). The eye blink component of the startle response was measured to quantify fear conditioning; post-task shock likelihood ratings for each stimulus were also obtained. All participants reported that shock likelihood varied with perceptual similarity to the CS+ and showed potentiated startle in response to CS +/- 20% stimuli. However, only the Val/Val group had potentiated startle responses to the CS+. Met allele carrying individuals were characterized by deficient fear conditioning--evidenced by an attenuated startle response to CS+ stimuli. Variation in the BDNF genotype appears related to abnormal fear conditioning, consistent with nonhuman animal work on the importance of BDNF in amygdala-dependent associative learning. The relation between genetic variation in BDNF and amygdala-dependent associative learning deficits is discussed in terms of potential mechanisms of risk for psychopathology.

Development of young children's understanding that the recent past is causally bound to the present.

The results of 6 studies (involving 304 children) suggested that 4- and 5-year-olds, but not 3-year-olds, understand that very recent past events determine the present. In Studies 1-3, 3- and 4-year-old children were introduced to 2 empty hiding locations. With children's backs to these locations, a camera recorded an experimenter secretly hiding a puppet in one of them. Children then viewed the videotape of what had just happened, along with another tape that depicted identical events except with a different child and with the puppet hidden in the other location. Only 4-year-olds were subsequently able to locate the puppet, even though 3-year-olds remembered the contents of the tapes and understood the equivalence between the video events and the real world. In Study 4, similar effects were obtained when a verbal analog of the test was presented to 3-5-year-olds. Studies 5 and 6 showed that when children observed 2 events in which they had just participated, only 5-year-olds understood that the most recent events were relevant.

Ambiguous stimuli: sex is in the eye of the beholder.

It is usually assumed that sexual material is easily identifiable by its content. The present study investigated whether subjects could be led to interpret ambiguous material as sexual or not via simple instructions. Thematically ambiguous written text was presented to 269 subjects. The principal independent variable was the content of advance information. Advance information was designed to suggest that the accompanying text had either a sexual or a nonsexual theme. After reading the story and completing an intervening task, subjects completed recall and recognition tasks based on the text. These data were used to determine the theme or story interpretation given by subjects. The information contained in the advance organizers influenced subjects' memories for and interpretations of the ambiguous story. When the story was preceded by introductory information that suggested sexual content, subjects tended to attribute sexual meaning to the story. Other subjects attributed a nonsexual meaning to the same text when it was preceded by nonsexual information. Findings suggest that under certain conditions, sex is in the "eye of the beholder."