Personality, negative affectivity and emotional intelligence: gender-differentiated relationships with physical exercise.

Introduction: Physical exercise is one of the most relevant lifestyle choices for the prevention of diseases; however, participation in this type of activity remains low. Therefore, it is necessary to deepen the understanding of related psychological factors in men and women. Objective: To determine whether personality traits, emotional intelligence and negative affective are differentially related to physical exercise characteristics in men and women. Method: A cross-sectional study was conducted with 579 physically active people (61.1% men) between 18 and 59 years of age. The Big Five Inventory (BFI-15p), Brief Emotional Intelligence Scale (EQ-i-M20), and Depression, Anxiety and Stress Scale (DASS-21) were used. Results: Compared with men, women exercised fewer days and minutes per week, had fewer years of participation and performed fewer different physical exercises. On the emotional intelligence scale, compared with men, women showed less stress management, adaptability and general mood but greater interpersonal intelligence. With regard to personality traits, compared with men, women showed greater openness, conscientiousness, agreeableness, and neuroticism. In males, heightened levels of general mood and extraversion were associated to a lasting commitment to physical exercise over time. Conversely, in females, depression was negatively associated with the years dedicated to physical exercise. Conclusion: Distinct approaches are essential for men and women, acknowledging the varied ways psychological factors are linked to physical exercise based on gender.

Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection.

Background and Objectives: Vitamin D, in addition to its effect on mineral homeostasis, plays a key role in muscle metabolism. Vitamin D supplementation is involved in muscle recovery after damage as a consequence of either pathology or after high-intensity exercise. In this context, the aim of this study was to analyze the effect of vitamin D on muscle fitness in elderly patients in the recovery phase after SARS-CoV-2 (COVID-19) infection. Materials and Methods: This pilot study was conducted at the Soria Norte Health Center. The study consisted of a double-blind trial with two groups of men (placebo and vitamin D-supplemented) (n = 15/group). Treatment with vitamin D (cholecalciferol: 2000 IU/day) and placebo was carried out for 6 weeks. Circulating hematological and biochemical parameters (total protein, glucose, vitamin D, urea, uric acid, aspartate aminotransferase/glutamic-oxaloacetic transaminase, alanine aminotransferase/glutamic-pyruvic transaminase, creatine kinase, lactate dehydrogenase, aldolase, gamma-glutamyl transferase and myoglobin) and the hormones cortisol and testosterone were determined. As for respiratory function tests, FEV1 and respiratory flow were also studied. For physical fitness tests, the "six-minute walk test" (6MWT) was used. Results: After vitamin D supplementation, we observed that serum creatine kinase levels returned to optimal values. This change suggests a protective role of vitamin D against muscle catabolism compared to placebo. In terms of physical test results, we observed only slight non-significant improvements, although patients reported feeling better. Conclusions: Vitamin D supplementation produces decreases in indicators of muscle damage, which may ultimately contribute to improving the health status and quality of life of patients who have suffered from COVID-19, during the recovery process.

Clinical Perspective and Translational Oncology of Liquid Biopsy.

The term liquid biopsy (LB) refers to the study of circulating tumor cells, circulating tumors nucleic acids free of cells or contained in exosomes, and information about platelets associated with tumors. LB can be performed in different biofluids and allows the limitations of tissue biopsy to be overcome offering possibilities of tumor identification reflecting in real time tumor heterogeneity. In addition, LB allows screening and early detection of cancer, real-time monitoring of therapy, stratification and therapeutic intervention, a therapeutic target and resistance mechanism, and a risk of metastatic relapse. Currently, LB has been shown to be effective for its application in different types of tumors including lung, colorectal, prostate, melanoma, breast and pancreatic cancer, by the determination and identification of biomarkers that with a high probability have the potential to change the way in which medical oncology could predict the course of the disease. These biomarkers make it possible to capture the heterogeneity of the cancer, monitor its clonal evolution, indicate new treatments or retreatments and evaluate the responses to different evolutionary and/or therapeutic pressures in the cancer disease.

Zerovalent nickel nanoparticles performance towards Cr(VI) adsorption in polluted water.

Heavy metals are one of the most common types of pollutants in ground water due to their wide sources, non-degradability and high toxicity. Many traditional wastewater treatments were not capable of removing enough such contaminants in order to meet quality standards. Nanosized zerovalent transition metals have emerged as a great candidate for ground water remediation, due to their simplicity and low fabrication cost, furthermore they can comply with simple chemical synthesis. Here, we present the synthesis of nano zerovalent nickel (nZVN) by a simple grinding reduction method. The obtained nZVN was characterized with XRD, SEM, EDS and BET surface area. The results confirms the formation of nZVN and the active particle cluster size ranges from 100 to 200 nm. N2 adsorption isotherms revealed that the formation mesoporous cluster of nZVN with good surface area. The adsorption of Cr(VI) using nZVN showed 96% removal efficiency for 10 ppm concentration, and even up to 98% when the temperature is slightly raised to 36 °C (309 K). The removal efficiencies of Cr by zerovalent nickel was well fitted by the Langmuir-Hinshelwood first order reaction kinetic model with deceptive rate constant values of 0.6699, 0.7956 and 1.0251 min-1 at temperature 200, 303 and 309 K, respectively. In total, our studies suggest that nanoscale zerovalent iron is a capable material for Cr(VI) remediation from groundwater.

Patterns of serum lipids derangements and cardiovascular risk assessment in patients with primary biliary cholangitis.

INTRODUCTION AND OBJECTIVES: Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune disease that disrupts the cholesterol metabolism. Our aim was to investigate the frequency of dyslipidemias and to evaluate the risk of cardiovascular events in a historic cohort of patients with PBC. PATIENTS: All patients attended from 2000 to 2009 with histological diagnosis of PBC were included and were compared with healthy controls. The 10-year cardiovascular risk was estimated by the Framingham risk score. RESULTS: Fifty four patients with PBC were included and compared to 106 controls. Differences in total cholesterol (263.8±123.9mg/dl vs. 199.6±40, p=0.0001), LDL-cholesterol (179.3±114.8 vs. 126.8±34.7, p=0.0001), HDL-cholesterol (62.4±36.2mg/dl vs. 47.3±12.3, p=0.0001) and triglycerides (149.1±59.1mg/dl vs. 126.4±55.4, p=0.001) were found. Hypercholesterolemia (>240mg/dl) was found in 52.4% of the patients with PBC vs. 11% in the control group, high LDL-cholesterol (160-189mg/dl) in 45.2% of the patients with PBC vs. 10% in controls and hyperalphalipoproteinemia (HDL-cholesterol >60mg/dl) in 45.2% of the patients with PBC vs. 16% in controls. The 10-year cardiovascular risk was 5.3%±5.9 in the patients with PBC and 4.1%±5.7 in the control group (p=0.723, IC 95%=0.637-1.104). Only one cardiovascular event (stroke) in a patient with PBC was registered in a mean follow up time of 57.9±36.5 months. CONCLUSIONS: Marked derangements in serum lipids and a high frequency of dyslipidemias are found in patients with PBC, however, these do not increase the risk of cardiovascular events.

A High-Demanding Strategy to Ensure the Highest Quality Standards of Oral Liquid Individualized Medicines for Pediatric Use.

Individualized medicines for pediatrics are a useful alternative if there is no correct dosage marketed for this segment (easy to swallow, adequate volume and content, correct composition for pediatrics, good organoleptic properties, etc.). Its validation process must ensure quality testing: its content uniformity, physical (homogeneity after shaking), chemical, and microbiological stability. Some of these attributes are checked by the recommendations of European Pharmacopoeia (Ph. Eur.), International Conference of Harmonization (ICH), and National Formularies but others are not. The aim of this study is to develop a general high-demanding strategy to ensure the final quality of liquid dosage forms testing and developing standard operating processes (SOPs) for the elaboration of individualized oral liquid medicines for pediatric use. Furosemide was used as an example of the validation of an individualized liquid solution for pediatric use. Three SOPs were selected according to their composition and the recommendations of liquid dosage forms for pediatric use. Quality attributes according to National Formularies, Ph. Eur., and ICH were tested: pH, organoleptic properties, uniformity of mass of delivered dose from multidose containers, and chemical stability. In this study, a general high-demanding strategy was elaborated to validate oral liquid dosage forms, including validation of the analytical method used to test their quality. A second part focuses on the elaboration of liquid formulations for pediatrics with the highest standards of quality taking into account CQAs that were not contemplated by official compendial such as content uniformity and physical stability.

Percepción de cualidades restauradoras de los espacios escolares de bachillerato en la ciudad de Xalapa, México / Perceived restorativeness in school spaces of high schools in Xalapa City, México / Percepção de qualidades restauradoras dos espaços escolares de ensino médio na cidade de Xalapa, México

El presente estudio se llevó a cabo con estudiantes de centros educativos de nivel bachillerato en Xalapa, México, y tuvo el objetivo de identificar y comparar las cualidades restauradoras percibidas en sus espacios escolares de acuerdo con la Teoría de la Restauración de la Atención. Se trabajó con una muestra no probabilística de 706 estudiantes de siete bachilleratos. Se recopilaron datos mediante una encuesta sociodemográfica y la Escala del Potencial Restaurador de los Espacios Escolares (EPREE).Los resultados mostraron que las áreas verdes de las escuelas eran los espacios de descanso con mayores cualidades restauradoras, y que los lugares de descanso favoritos poseían más cualidades restauradoras que los no favoritos. Los alumnos varones, los de más edad y aquellos cuya madre (jefe de familia) tenía niveles inferiores de estudios reportaron una percepción más positiva de los espacios escolares. Las escuelas más grandes y con áreas verdes fueron mejor valoradas en las dimensiones de fascinación, posibilidad de estar alejado, y extensión. Los resultados confirmaron las propuestas centrales de la teoría de la restauración de la atención en el contexto de los espacios escolares.

The present study was carried out with high school students from Xalapa, Mexico. Its aim was to identify and compare the perceived restorativeness in their school environments according to the attention restoration theory. This work is based on a non-probabilistic sample of 706 students from seven high schools. All data were compiled by a sociodemographic survey and the Scale of the Restorative Potential of School Spaces (EPREE, for its the Spanish acronym). The results proved that green areas were the rest spaces with major restorative qualities and that the students' favorite rest places possessed more restorative qualities than other places. Males, older pupils and those whose mother (head of the family) had a lower educational level reported a more positive perception of the school spaces. The largest schools with green areas obtained a higher evaluation for their dimensions of fascination, being away and extent. The results confirmed the main propositions of the attention restoration theory.

Este artigo foi realizado com estudantes de centros educativos de ensino médio em Xalapa (México) e teve como objetivo identificar e comparar as qualidades restauradoras percebidas em seus espaços escolares de acordo com a Teoria da Restauração da Atenção. Trabalhou-se com uma amostra não probabilística de 706 estudantes de sete turmas de ensino médio. Coletaramse dados mediante uma enquete sociodemográfica e a Escala do Potencial Restaurador dos Espaços Escolares (EPREE). Os resultados mostraram que as áreas verdes dos centros eram os espaços de descanso com maiores qualidades restauradoras e que os lugares de descanso preferidos pelos estudantes possuíam mais qualidades restauradoras do que os não preferidos. Os estudantes do gênero masculino, os de mais idade e aqueles cuja mãe (cabeça de família) tinha níveis inferiores de escolaridade relataram uma percepção mais positiva dos espaços escolares. Os maiores centros e com áreas verdes tiveram melhores avaliações nas dimensões de fascinação, possibilidade de estar isolado e extensão. Os resultados confirmaram as propostas centrais da Teoria da Restauração da Atenção no contexto dos espaços escolares.

[A 35-year report of the study of group on gastrointestinal cancer in Mexico City: variations in frequency of different digestive tract neoplasms among different socioeconomic statuses]. / Variaciones en la frecuencia de cáncer del aparato digestivo en el transcurso de 35 años en cuatro instituciones de la Ciudad de México de distinto nivel socioeconómico.

BACKGROUND: Since the middle of the last century, North America and occidental countries have reported variations in the frequency of gastrointestinal neoplasms. Several environmental factors, mainly nutritional and dietary exposure, as well as habits have contributed to these changes. We have documented these changes in Mexico during the last 35 years. AIMS: To define the epidemiologic changes of gastrointestinal neoplasms during the last three decades in our population. METHODS: We summarized the evidence of an observational study, registering the frequency of different gastrointestinal malignancies from four institutions of socioeconomically different populations in Mexico City during 35 years. The Mexican National Academy of Medicine supported this effort. During this period, two nutritional surveys took place, letting us define the relationship between dietary changes and cancer occurrence. RESULTS: Replacement of gastric cancer by colorectal cancer as the leading gastrointestinal malignancy. Relationship between cancer and diet changes. Increase of esophageal adenocarcinoma in relation to epidermoid carcinoma secondary to gastroesophageal reflux and Barrett's esophagus rising incidence. Gall bladder cancer had a high frequency in one institution, probably related to genetic and racial factors. CONCLUSIONS: This epidemiologic data should lead us to implement sanitary measures for the prevention, early diagnosis, and appropriate treatment of gastrointestinal neoplasms.

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.

OBJECTIVE: Alcoholic hepatitis (AH) is a severe clinical condition that needs novel therapies. The identification of targets for therapy is hampered by the lack of animal models of advanced AH. The authors performed a translational study through a transcriptome analysis in patients with AH to identify new molecular targets. DESIGN: Hepatic gene expression profiling was assessed by DNA microarray in patients with AH (n=15) and normal livers (n=7). Functional analysis was assessed by gene set enrichment analysis. Quantitative PCR was performed in patients with AH (n=40), hepatitis C (n=18), non-alcoholic steatohepatitis (n=20) and in mouse models of acute and chronic liver injury. Protein expression was assessed by immunohistochemistry and western blotting. RESULTS: Gene expression analysis showed 207 genes >5-fold differentially expressed in patients with AH and revealed seven pathways differentially regulated including 'cytokine-cytokine receptor interaction'. Several tumour necrosis factor (TNF) superfamily receptors, but not ligands, were overexpressed in AH. Importantly, Fn14 was the only TNF superfamily receptor exclusively upregulated in AH compared with other liver diseases and correlated with both 90-day mortality and severity of portal hypertension. Fn14 protein expression was detected in areas of fibrogenesis and in a population of hepatocytes. Fn14 expression was increased in experimental models of liver injury and was detected in progenitor cells. CONCLUSION: Translational research revealed that TNF superfamily receptors are overexpressed in AH. Fn14, the receptor for TNF-like weak inducer of apoptosis, is selectively upregulated in patients with AH. TNF superfamily receptors could represent a potential target for therapy.

Relación entre el nivel de conocimientos con el cumplimiento de las medidas de bioseguridad en el profesional de enfermería de la Unidad de Cuidados Intensivos en el Hospital Nacional Guillermo Almenara Irigoyen EsSalud - 2010 / Relationship between the level knowledge compliance biosegurity measures in the professional nursing care unit National Hospital Intensive Guillermo Almenara Irigoyen EsSalud 2010

El presente estudio de investigación titulado "Relación entre el nivel de conocimientos con el cumplimiento de las medidas de bioseguridad en el profesional de enfermería de la unidad de cuidados intensivos en el Hospital Nacional Guillermo Almenara Irigoyen EsSalud-2010" tiene como objetivo determinar la relación entre el nivel de conocimientos y el cumplimiento de las medidas de bioseguridad en el profesional de enfermería de la Unidad de Cuidados Intensivos en el Hospital Nacional Guillermo Almenara Irigoyen EsSalud. El Estudio es de tipo cuantitativo, aplicativo, descriptivo transversal siendo la población el personal profesional de enfermería del Hospital Nacional Guillermo Almenara Irigoyen EsSalud. Se tomo una muestra de 32 enfermeras, la técnica que se utilizo fue la entrevista, como instrumentos se utilizo el cuestionario para recoger datos sobre el nivel de conocimientos y la guía de observación para recoger los datos sobre la aplicación de las medidas de bioseguridad por el profesional de enfermería a través de observaciones directas. Para realizar el estudio se tomo en consideración la autorización de la institución y el consentimiento informado de las enfermeras del Hospital Nacional Guillermo Almenara Irigoyen, haciendo de su conocimiento que toda información que brinde será de carácter anónimo y solo con fines de investigación. Las Conclusiones fueron: El mayor porcentaje de profesionales de enfermería tuvieron un nivel de conocimiento medio de las medidas de bioseguridad básicamente en la realización de lavado de mano, en la utilización de barreras protectoras así como el adecuado lugar de descarte del material punzocortante, en cuanto al cumplimiento el mayor porcentaje de los profesionales de enfermería si cumple con las medidas de bioseguridad refiriéndose básicamente a la realización de lavado de manos y utilización de barreras protectoras

This research study entitled "Relationship between the level knowledge compliance biosecurity measures in the professional nursing care unit National Hospital Intensive Guillermo AImenara Irigoyen EsSalud-2010 " aims to determine the relationship between the level of knowledge and implementation of biosecurity measures in professional nursing Intensive Care Unit in National Hospital Guillermo Almenara Irigoyen's Health. The Survey is of type quantitative application, descriptive being the population cross staff Hospital nurse Guillermo Almenara Irigoyen National EsSalud, took a sample of 32 nurses, the technique used was the interview was used as instruments questionnaire to collect data on level of knowledge and guide observation to collect data on implementation of biosecurity measures by the nurse through direct observations. To perform study took into consideration the authorization of the institution and informed consent nurse National Hospital Guillermo Almenara Irigoyen, making your knowledge Any information you provide will be anonymous and only for purposes of research. The conclusions were: higher per centage of professionals had a level of nursing knowledge through measures primarily in the conduct biosafety hand washing, the use of protective barriers and appropriate material disposal site sharps, in meeting the higher per centage of professionals if you meet the nursing measures Biosecurity referring mainly to the implementation of hand washing and use of protective barriers

AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fibrosis.

Liver biopsy is the recognized gold standard for liver fibrosis staging. The aspartate aminotransferase to platelet ratio index (APRI) has been proposed as a noninvasive and readily available tool for the assessment of liver fibrosis in chronic hepatitis C (CHC). This study aimed to validate, in a Mexican tertiary health care setting, the diagnostic usefulness of APRI in CHC, nonalcoholic fatty liver disease (NAFLD) and autoimmune hepatitis (AIH). In an observational, cross-sectional, comparative and retrolective fashion, consecutive patients with CHC, NAFLD or AIH were evaluated. Fibrosis was staged using the METAVIR scale. Receiver operating characteristic ROC curves were constructed for significant fibrosis, advanced fibrosis and cirrhosis. One-hundred-sixty-four CHC, 30 NAFLD and 42 AIH patients were evaluated. For the diagnosis of significant fibrosis, APRI values delimited an area under de ROC curve (AUC) of 0.776 in CHC, 0.564 in NAFLD, and 0.602 in AIH patients. For advanced fibrosis, the AUCs were 0.803, 0.568 and 0.532 in CHC, NAFLD and AIH patients, respectively. For cirrhosis, AUCs were 0.830 and 0.599 in CHC and AIH patients. In conclusion, APRI can be a useful noninvasive alternative for the diagnosis of significant fibrosis and cirrhosis in our CHC patients. APRI values of < or = 0.3 and < or = 0.5 rule out significant fibrosis and cirrhosis, and a value of > or = 1.5 rules in significant fibrosis. In patients with NAFLD, APRI values tend to increase with the degree of fibrosis, suggesting that it could be useful in this disease. APRI appears to be of no value in patients with AIH.

Wallenberg's Syndrome: An Unusual Case of Dysphagia.

A 56-year-old man presented with sudden-onset oropharyngeal dysphagia and vomiting of central etiology. Neurological evaluation showed uvula deviation to the left, paresis of the mid-right portion of the soft palate, lateralization of gaze to the right side, and dysphonia. Magnetic resonance imaging (MRI) showed an infarction in the left lateral medullary region, therefore the diagnosis of Wallenberg's syndrome was established. The neurological issues along with the dysphagia gradually improved and the patient was discharged.

[Gastrointestinal cancer in four medical centers in Mexico City. A 25-year study]. / Estudio de 25 años de cáncer del aparato digestivo en cuatro instituciones de la Ciudad de México.

BACKGROUND: Digestive cancer is an important mortality cause in Mexico. In the past decades a change in the frequency of digestive malignancies has been observed. AIM: To evaluate the frequency of digestive malignancies in four hospitals in México City during a 25 years period. PATIENTS AND METHODS: All digestive cancers were studied at the following hospitals: Hospital General de México (HGM), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirdn (INCMNSZ), Centro Médico Nacional 20 de Noviembre (CMN20Nov) and Hospital Español (HE). The diagnosis was established by histopathology study. Cases frequency is were compared in three-years intervals. RESULTS: 8,879 digestive cancers were documented. Gastric cancer frequency decreased during the study period at HGM (59% in 1978 to 38% in 2003) and at INCMNSZ (32% in 1978 to 24% in 2003), p = 0.013 andp = 0.012 respectively. Colon cancer frequency increased significantly at HGM (15% in 1978 to 36% in 2003, p < 0.001) and at CMN20Nov (20% in 1981 to 51% in 2003, p < 0.01) and at INCMNSZ with tower significancy. A change in squamous esophageal cancer (SC) and esophageal adenocarcinoma (EA) frequencies was observed in at the INCMNSZ, with a SC:EA ratio of 7:1 between 1977 to 1987and 1:2 between 1988 to 2005. Alimentary habits questionnaries showed early during the study diferences in caloric intake between the four hospitals (mean HGM: 2,169 kcal, INCMNSZ: 2,195 kcal, CMN2O0Nov: 3,133 y 2,262 kcal HE) and in animal protein intake, being lower at HGM (9.3 g/day) and IN-CMNSZ (11.8 g/day) compared with CMN2ONov (45.6 g/day) and HE (63.4 g/day), in the next questionnary these differences dissapeared and there was an increase in both, the same was observed for lipid intake. CONCLUSIONS: We observed a reduction in gastric cancer fre quency and an increase in colon cancer in 25 years, probably associated to a change in habits dietary. Also a change in the main histological type of esophageal cancer was observed, initially epidermoid cancer was the most frequent and in the last 10 years adenocarcinoma is the most frequent.