ABSTRACT
Chlorhydrate nefopam was used in the prophylaxis and treatment of postoperative shivering in 54 patients undergoing general anesthesia for radical cystectomy with trans-intestinal anastomosis. Postoperative shivering was not observed in any of the patients treated with nefopam before coming round, whereas it occurred in 55% of patients treated with placebo. Chlorhydrate nefopam subsequently stopped shivering in all these patients. The main side effects observed took the form of delayed awakening in 11% of patients receiving prophylactic treatment and somnolence lasting 5-10 minutes in all other patients.
Subject(s)
Nefopam/therapeutic use , Postoperative Complications/drug therapy , Shivering/drug effects , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
The reproductive possibilities of cardiopathic patients with cardiac valvular prostheses have greatly improved in the past forty years. The correct management of this risk pregnancies remains a problem, however, especially as regards the chronic anticoagulant treatment to which these patients are subjected. The thirty years experience of a heart surgery-obstetric team is reported here. This included 14 pregnancies in women with aortic or mitral valvular prostheses. The problems relating to anticoagulant treatment in pregnancy and during labour are discussed.
