Sindrome de Stevens-Johnson. / StevensJohnson syndrome

Os autores estudando 23 casos de sindrome de Stevens-Johnson, encontraram a seguinte relacao quanto aos possiveis agentes etiologicos: 1) casos em que nao houve nenhum sinal de infeccao previa e estariam, entao, relacionados a drogas: 7 casos (30,43%), 1 medicamento previo; 1 caso (4,35%), 2 medicamentos previos; 2) associacao de infeccoes previas (vias urinarias e/ou vias aereas superiores) e drogas: 10 casos (43,48%); 3) infeccoes previas sem relacao a drogas: 3 casos (13,04%); 4) desconhecidos: 2 casos. Comentarios foram feitos sobre a sindrome de Stevens -Johnson, revelando-se a dificuldade com que se depararam em face do provavel agente etiologico

The effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide on acute viral hepatitis.

We studied the effect of 1-beta-ribofuranosyl-1,2,4-traizole-3-carboxamide (ribavirin) on 66 patients with acute viral hepatitis, by a double-blind study. Thirty-three of these patients received the active drug and the other 33 received a placebo. The effect of ribavirin was evaluated by the clinical picture and by the changes in both direct and total serum bilirubin and in the activity of serum glutamic-pyruvic and glutamic-oxaloacetic transaminases. There was a significant decrease in serum bilirubin, SGOT, and SGPT from the 5th to 10th day of treatment in the ribavirin group. In the placebo group such a decrease was observed but was not statistically significant.