ABSTRACT
Diagnosing concomitant transverse myelitis (TM) and Guillain-Barré syndrome (GBS) can be challenging. We report a case of an elderly patient presenting with acute sensory and motor disturbances in the four limbs, associated with urinary retention, ophthalmoparesis, facial weakness, and dysarthria. Electrodiagnostic studies were consistent with acute motor sensory axonal neuropathy (AMSAN), and imaging showed a longitudinally extensive tumefactive contrast-enhancing hyperintense spinal cord lesion extending from T6 to the cone. Concomitant AMSAN and TM have not been previously reported in the elderly. Comorbid TM and other GBS variants have been previously reported. Intravenous methylprednisolone, plasma exchange, cyclophosphamide, or combination therapies are usually used, although there are no randomized controlled studies regarding treatment choices.
ABSTRACT
Sclerotinia sclerotiorum is an important soybean pathogen. The objectives of this study were to evaluate levels of resistance of soybean genotypes to the fungus, and to determine the effects of different incubation environments on host resistance and pathogen aggressiveness. Two experiments were conducted using 103 genotypes from the seed collection of Laboratório de Desenvolvimento de Germoplasma, Universidade Federal de Uberlândia (LAGER-UFU). The first experiment was conducted in a greenhouse, and the second in a growth chamber. Inoculations were performed by the straw test method using two Brazilian isolates of the fungus, one from Uberaba, Minas Gerais, and the other from Jataí, Goiás. The average stem-lesion length (cm) at 5 days post-inoculation was used to determine levels of resistance. Overall, the most resistant genotype was EMGOPA-316, and the most susceptible genotype was LAGER-29. Incubation in a growth chamber and use of the Jataí isolate generated the most reliable data, and multivariate analysis indicated that the genotypes were divergent under the growth chamber conditions. Therefore, when studying host resistance of soybean genotypes to S. sclerotiorum, it is important to use environmental conditions favorable to the fungus and aggressive isolates.
Subject(s)
Ascomycota/isolation & purification , Disease Resistance , Glycine max/genetics , Genome, Plant , Genotype , Phylogeny , Plant Diseases/genetics , Plant Diseases/microbiology , Glycine max/microbiologyABSTRACT
Acrocomia aculeata (Jacq.) Lodd. ex Mart. is a plant species commonly used as a foodstuff and also for treating diseases, since it contains high concentrations of antioxidant compounds and monounsaturated fatty acids. Considering its ethnopharmacological relevance, the aim of the present study was to assess the cytotoxic, genotoxic, and mutagenic effects of an oil extracted from the pulp of A. aculeata (OPAC) in rats. In addition, a chromatographic characterization of the fatty acids present in OPAC was performed. Male and female Wistar rats were treated orally with 125, 250, 500, 1000, or 2000 mg/kg/body weight OPAC. The effects of OPAC ingestion were determined by performing the comet assay and micronucleus test. The comet assay data demonstrated that OPAC did not increase the frequency or rate of DNA damage in groups treated with any of the concentrations assessed compared to that in the negative control group. In the micronucleus test, the animals treated did not exhibit any cytotoxic or mutagenic changes in peripheral blood erythrocytes. The results demonstrated that OPAC did not exhibit cytotoxic, genotoxic, or mutagenic effects in Wistar rats, thereby increasing the evidence for the safety of oil extracted from this plant.
Subject(s)
Arecaceae/chemistry , Mutagens/toxicity , Plant Extracts/toxicity , Animals , Cell Death/drug effects , DNA Damage , Erythrocytes/drug effects , Erythrocytes/metabolism , Female , Male , Micronuclei, Chromosome-Defective , Mutagenesis/drug effects , Rats, WistarSubject(s)
Cognition Disorders/psychology , Dementia/psychology , Neurocysticercosis/psychology , Adolescent , Adult , Animals , Cognition Disorders/etiology , Dementia/etiology , Female , Host-Parasite Interactions , Humans , Inflammation/pathology , Male , Mice , Middle Aged , Neurocysticercosis/complications , Neurocysticercosis/parasitology , Taenia , Taeniasis/complications , Young AdultABSTRACT
OBJECTIVES: Neurocysticercosis (NCYST) is the most frequent CNS parasitic disease worldwide, affecting more than 50 million people. However, some of its clinical findings, such as cognitive impairment and dementia, remain poorly characterized, with no controlled studies conducted so far. We investigated the frequency and the clinical profile of cognitive impairment and dementia in a sample of patients with NCYST in comparison with cognitively healthy controls (HC) and patients with cryptogenic epilepsy (CE). METHODS: Forty treatment-naive patients with NCYST, aged 39.25 +/- 10.50 years and fulfilling absolute criteria for definitive active NCYST on MRI, were submitted to a comprehensive cognitive and functional evaluation and were compared with 49 HC and 28 patients with CE of similar age, educational level, and seizure frequency. RESULTS: Patients with NCYST displayed significant impairment in executive functions, verbal and nonverbal memory, constructive praxis, and verbal fluency when compared with HC (p < 0.05). Dementia was diagnosed in 12.5% patients with NCYST according to DSM-IV criteria. When compared with patients with CE, patients with NCYST presented altered working and episodic verbal memory, executive functions, naming, verbal fluency, constructive praxis, and visual-spatial orientation. No correlation emerged between cognitive scores and number, localization, or type of NCYST lesions on MRI. CONCLUSIONS: Cognitive impairment was ubiquitous in this sample of patients with active neurocysticercosis (NCYST). Antiepileptic drug use and seizure frequency could not account for these features. Dementia was present in a significant proportion of patients. These data broaden our knowledge on the clinical presentations of NCYST and its impact in world public health.
Subject(s)
Brain/parasitology , Cognition Disorders/physiopathology , Cognition Disorders/parasitology , Dementia/physiopathology , Dementia/parasitology , Neurocysticercosis/complications , Adolescent , Adult , Anticonvulsants/adverse effects , Brain/pathology , Case-Control Studies , Cognition Disorders/diagnosis , Cross-Sectional Studies , Dementia/diagnosis , Disability Evaluation , Epilepsy/drug therapy , Epilepsy/etiology , Epilepsy/physiopathology , Female , Humans , Language Disorders/diagnosis , Language Disorders/etiology , Language Disorders/physiopathology , Magnetic Resonance Imaging , Male , Memory Disorders/diagnosis , Memory Disorders/etiology , Memory Disorders/physiopathology , Middle Aged , Neurocysticercosis/pathology , Neurocysticercosis/psychology , Neuropsychological Tests , Young AdultABSTRACT
BACKGROUND: Patients with brief, complex partial seizures frequently suffer from tiredness and decreased productivity that continue well beyond the postictal period. A possible explanation is that seizures, even when occurring during the day, disrupt sleep the following night. OBJECTIVE: To determine the effect of temporal lobe complex partial seizures on sleep structure and daytime drowsiness. METHODS: Patients with temporal lobe epilepsy were admitted for video-electroencephalography monitoring. All-night polysomnography was recorded under the following 3 conditions: seizure free, seizure during the day before the recording, and seizure during the recording. Percentage of time in each sleep stage, sleep efficiency, and time to first and second rapid eye movement (REM) period were compared for seizure vs control conditions. Daytime drowsiness was also measured, using a modified maintenance of wakefulness test and 2 subjective drowsiness tests. RESULTS: Daytime seizures reduced REM from 18%+/-1% to 12%+/-2% (P = .003). Night seizures reduced REM from 16%+/-1% to 6.8%+/-2% (P<.001). Night seizures also significantly reduced stages 2 and 4 while increasing stage 1 sleep. Night seizures, but not day seizures, significantly reduced sleep efficiency, increased time to first REM period, and increased drowsiness as measured by the maintenance of wakefulness test. CONCLUSIONS: Temporal lobe complex partial seizures decrease REM sleep, particularly when occurring during sleep but also when occurring on the previous day. This may, in part, be responsible for the prolonged impairment of functioning that some patients report following seizures.
Subject(s)
Epilepsy, Temporal Lobe/physiopathology , Eye Movements/physiology , Seizures/physiopathology , Sleep, REM/physiology , Adult , Circadian Rhythm , Fatigue/etiology , Female , Humans , Male , Middle AgedABSTRACT
An unusual case of a young woman, heterozygote for Fabry gene is reported, who presented bilateral thalamic infarcts due to occlusions of central nervous system vessels. Three other members of her family were studied. Fabry's disease (angiokeratoma corporis diffusum) is included among the rare causes of ischemic stroke in young adults.
Subject(s)
Cerebral Infarction/etiology , Fabry Disease/genetics , Thalamus/blood supply , Adult , Aged , Fabry Disease/complications , Female , Humans , Male , Middle AgedABSTRACT
Because of an unexpectedly high rate of worsening, we report the results of treatment of Guillain-Barré syndrome with a standard regimen of human immune globulin (HIG) in 15 consecutive patients. Patients were treated with 1.5 g/kg HIG for 4 days beginning a mean of 7 days after the first symptoms. Eight stabilized or improved, but seven deteriorated during or within the first 5 days after treatment, and four remained ventilator-dependent for at least 2.5 months. One had a severe relapse 5 weeks after treatment. Five patients subsequently received plasma exchange and two improved. Our experience varies from previous reports that have endorsed HIG treatment for Guillain-Barré syndrome.
Subject(s)
Immunization, Passive , Polyradiculoneuropathy/physiopathology , Polyradiculoneuropathy/therapy , Action Potentials , Adult , Age Factors , Aged , Female , Humans , Immunoglobulins/administration & dosage , Infusions, Intravenous , Male , Middle Aged , Muscles/physiopathology , Time FactorsABSTRACT
We report a case of fatal chagasic meningoencephalitis in an AIDS patient. Acute exacerbation of chronic Chagas' disease with involvement of the CNS is uncommon and occurs only in immunocompromised patients. This is the third such reported reactivation and it underscores the importance of considering Chagas' disease in HIV-positive patients from endemic regions.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Chagas Disease/complications , Meningoencephalitis/etiology , Adult , Chagas Disease/pathology , Humans , MaleABSTRACT
HTLV-1 antibodies were investigated in serum and in CSF of 150 patients with neurologic disorders mainly myelopathies. The patients were considered into three groups according to the possible relationship of their disease to the presence of HTLV-1 antibodies: no relationship risk (control group), occasional risk group, and possible risk group. In this latter are 56 patients with crural spastic paraparesis or paraplegia of unknown etiology (SP). HTLV-1 antibodies were tested by the passive particle-agglutination method for anti-ATLA antibody detection. The search was negative in all patients of the control group, and positive (serum and/or CSF) in 16.5% of the patients from the second group and in 55.4% of the SP patients group. Clinical patterns in SP cases with HTLV-1 antibodies were those of tropical spastic paraparesis (TSP). CSF patterns considered (cytology, protein content and gamma-globulins rate) were different between TSP group with HTLV-1 antibodies in CSF and SP group with no HTLV-1 antibodies detection either in serum or in CSF. The difference was significant. Results of this investigation confirm the high incidence of TSP in Brazil, and bring additional indication for searching HTLV-1 antibodies in the CSF.
Subject(s)
HTLV-I Antibodies/analysis , Paraparesis, Tropical Spastic/immunology , Adolescent , Adult , Aged , Aged, 80 and over , Brazil , Female , Humans , Male , Middle Aged , Paraparesis, Tropical Spastic/blood , Paraparesis, Tropical Spastic/cerebrospinal fluidABSTRACT
Foi pesquisada a presença de HTLV-1 anticorpos no soro e no LCR de 150 pacientes com afecçöes do sistema nervoso, particularmente mielopatias. Os pacientes foram considerados segundo três grupos, de acordo com a possível relaçäo entre a doença e a presença de HTLV-1 anticorpos: sem risco de relaçäo (grupo controle); grupo de risco ocasional; grupo de risco possível. Este último abrange 56 pacientes com paraparesia ou paraplegia crural espástica de etiologia näo esclarecida (PE). Foi utilizada para a pesquisa a técnica de aglutinaçäo passiva de partículas para anti-ATLA anticorpo, sendo obtidos os seguintes resultados: näo foram detectados HTLV-1 anticorpos no grupo controle e foram detectados (soro e/ou LCR) em 16,5% dos pacientes do segundo grupo e em 55,4% daqueles do terceiro grupo. O quadro clínico dos pacientes com PE e HTLV-1 anticorpos era compatível a paraparesia espática tropical (PET). Foi verificada diferença significativa quanto a dados do exame de LCR (citologia, concentraçäo proteica e teor de globulinas gama) ao se compararem os pacientes com PET com HTLV-1 anticorpos no LCR àqueles com PE em que tais anticorpos näo foram detectados nem no soro e nem no LCR. Os resultados deste estudo confirmam a elevada incidência da PET no Brasil e ilustram a necessidade da pesquisa desses anticorpos também no LCR
Subject(s)
Humans , Child , Adolescent , Adult , Middle Aged , Male , Female , HTLV-I Antibodies/analysis , Paraparesis, Tropical Spastic/immunology , Aged, 80 and over , BrazilABSTRACT
Primary reading epilepsy is a rare form of reflex epilepsy, in which reading is the specific stimulus evoking attacks. The authors report a case of an 18-year-old man who since the age of 17 presented myoclonic jaw jerking provoked exclusively by reading. In one episode, in which reading was not interrupted, jerks were followed by a generalized convulsive seizure. EEG with routine activating procedures was normal, while EEG recorded during reading showed bilaterally synchronous paroxysmal small-voltage spikes, more prominent in frontocentral regions, coinciding with jaw myoclonus. Complete clinical seizures control and EEG normalization were achieved with clonazepam 2 mg daily in a 24-month follow-up.
Subject(s)
Clonazepam/therapeutic use , Epilepsy/drug therapy , Reading , Adolescent , Electroencephalography , Epilepsy/etiology , Epilepsy/physiopathology , Humans , MaleABSTRACT
A epilepsia primária da leitura é forma rara de epilepsia reflexa, na qual a leitura age como estímulo específico paa o desencadeamento de crises. Os autores relatam o caso de um paciente do sexo masculino, com 18 anos de idade, apresentando há um ano abalos mioclônicos da mandíbula provocados exclusivamente pela leitura. Em um episódio no qual o paciente prosseguiu a leitura, os abalos se seguiram de crise tônico-clônica generalizada. O EEG, efetuado com métodos de ativaçäo rotineira, foi normal, enquanto o EEG registrado durante leitura mostrou descargas de espículas geralmente de baixa voltagem, bilaterais e síncronas, predominando nas regiöes frontocentrais, concomitantes à manifestaçäo clínica de mioclonias da mandíbula. O uso de clonazepam, na dose de 2mg diários, levou ao controle completo das crises e normalizaçäo do EEG num período de seguimento de 24 meses
Subject(s)
Adolescent , Humans , Male , Clonazepam/therapeutic use , Epilepsy/drug therapy , Reading , Electroencephalography , Epilepsy/etiologyABSTRACT
In this preliminary report the authors present the finding of a high prevalence (37.5%) of seropositivity of antibodies to HTLV-I tested by Western blotting in a sample of 16 Brazilian patients with chronic myelopathies of undetermined origin.
Subject(s)
Paraparesis, Tropical Spastic/epidemiology , Blotting, Western , Brazil/epidemiology , Deltaretrovirus Antibodies/analysis , Humans , Immunoenzyme TechniquesABSTRACT
Neste relato preliminar os autores registram a constataçäo de alta prevalência do soropositividade para anticorpos dirigidos ao HTLV-I detectados pelo método de Westernblot (37,5%) em amostra de 16 pacientes brasileiros com mielopatias crônicas de causa näo determinadas
