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Cell Biochem Funct ; 31(2): 136-51, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22961602

ABSTRACT

The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non-enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L-NAME and Exercise L-NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L-NAME-treated group was reverted by physical training in serum from the Exercise L-NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L-NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L-NAME group when compared with the L-NAME group (P < 0·05). There was a decrease in the non-protein thiols (NPSH) levels in the L-NAME-treated group when compared with the normotensive groups (P < 0·05). In the Exercise L-NAME group, there was an increase in NPSH levels when compared with the L-NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L-NAME group were reverted to levels close to normal by exercise in the Exercise L-NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L-NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension.


Subject(s)
Hypertension/pathology , Oxidative Stress , Physical Conditioning, Animal , Animals , Ascorbic Acid/metabolism , Biomarkers/metabolism , Blood Pressure , Body Weight , Catalase/blood , Heart Rate , Hypertension/blood , Hypertension/physiopathology , Kidney/enzymology , Kidney/pathology , Lipid Peroxidation , Lipids/blood , Male , NG-Nitroarginine Methyl Ester , Nitric Oxide/metabolism , Oxidation-Reduction , Protein Carbonylation , Rats , Rats, Wistar , Sulfhydryl Compounds/blood , Superoxide Dismutase/blood , Swimming , Systole , Thiobarbituric Acid Reactive Substances/metabolism
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