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1.
J Med Virol ; 91(1): 151-154, 2019 01.
Article in English | MEDLINE | ID: mdl-30133759

ABSTRACT

The current study aimed to determine the seroprevalence of hepatitis E virus (HEV) infection among persons who use crack from Midwest region of Brazil. Sera samples from 698 users of crack, collected from November 2013 to July 2015 were tested for anti-HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) markers. Of the 698 serum samples, 99 (14.2%) were positive for anti-HEV IgG. Two samples were positive for anti-HEV IgM but both were negative for HEV RNA. The variables independently associated with anti-HEV positivity were increasing age and absence of stable partnership. This study showed high prevalence of past hepatitis E virus infection among persons who use crack.


Subject(s)
Antibodies, Viral/blood , Crack Cocaine/administration & dosage , Hepatitis E virus/immunology , Hepatitis E/epidemiology , Substance-Related Disorders/complications , Adolescent , Adult , Aged , Brazil/epidemiology , Female , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Middle Aged , RNA, Viral/blood , Risk Factors , Seroepidemiologic Studies , Young Adult
2.
PLoS Negl Trop Dis ; 9(4): e0003691, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25886507

ABSTRACT

BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan. OBJECTIVE: This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV. STUDY DESIGN: A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing. RESULTS: The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese). CONCLUSION: The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.


Subject(s)
Emigrants and Immigrants/statistics & numerical data , HTLV-I Infections/epidemiology , Human T-lymphotropic virus 1/genetics , Phylogeny , Adult , Age Factors , Antibodies, Viral/blood , Base Sequence , Brazil/epidemiology , Cross-Sectional Studies , Enzyme-Linked Immunosorbent Assay , Female , Human T-lymphotropic virus 1/immunology , Humans , Immunoblotting , Japan/ethnology , Male , Molecular Sequence Data , Prevalence , Sequence Analysis, DNA
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