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1.
J Cardiovasc Med (Hagerstown) ; 17(10): 750-5, 2016 Oct.
Article in English | MEDLINE | ID: mdl-26765992

ABSTRACT

AIMS: The aim of the present study is to determine pregnancy outcome with regard to the risk class and the modality way of referral to our joint Cardiac Obstetric Clinic. METHODS: This is a prospective observational study. Patients referred to our clinic between 2011 and 2014 were included. Reason and timing for referral were recorded. Two groups were identified: women who were known to have cardiac disease before referral (group I) and women who were not (group II). Pregnancies were managed as recommended by the ESC Guidelines. Cardiac events were defined as death, heart failure requiring treatment, documented tachyarrhythmias, thromboembolic events and need for urgent endovascular procedures or surgery. RESULTS: Of the 110 pregnancies, 51 (47%) were in group I and 57 (53%) in group II. Congenital (44%) and valvular (27%) diseases were the most frequent diagnosis. Thirty-two percent of patients were in WHO risk classes III-IV. Thirty percent were referred for symptoms, 70% for risk assessment. Women in group II were evaluated later in pregnancy than those in group I (25.6 ±â€Š9 vs. 21.4 ±â€Š9; P < 0.01). Cardiovascular events occurred in 15 (13.6%) pregnancies and were more common in WHO risk classes III-IV (11, P < 0.001), in group II (12, P= 0.02) and in patients referred for symptoms (11, P < 0.001). Stillbirths occurred only in classes III-IV (three pregnant, 2.7%). CONCLUSION: There was no maternal or neonatal mortality and an overall acceptable incidence of cardiovascular events but a relevant percentage of pregnant were first referred late and/or for the onset of symptoms. Events were more frequent in these patients. Further efforts are needed to optimize referral to specialized centers.


Subject(s)
Heart Defects, Congenital/epidemiology , Maternal Mortality , Pregnancy Complications, Cardiovascular/classification , Pregnancy Complications, Cardiovascular/epidemiology , Pregnancy Outcome , Adult , Female , Humans , Italy , Middle Aged , Practice Guidelines as Topic , Pregnancy , Prospective Studies , Referral and Consultation/statistics & numerical data , World Health Organization , Young Adult
2.
Cardiol Young ; 25(1): 174-6, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24438356

ABSTRACT

A female baby suffered from a rare association between histiocytoid cardiomyopathy, left ventricular non-compaction, and Wolff-Parkinson-White syndrome causing severe and recurrent arrhythmic storms. Antiarrhythmic drugs, radiofrequency ablation of Purkinje tissue, and sympathetic denervation were ineffective. The implant of a cardiac defibrillator allowed her to survive till heart transplant. Compound mutation of CACNA2D1 and RANGRF genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy.


Subject(s)
Calcium Channels/genetics , Cardiomyopathies/congenital , DNA/genetics , Electron Transport Complex III/deficiency , Mutation , ran GTP-Binding Protein/genetics , Alleles , Calcium Channels/metabolism , Cardiomyopathies/diagnosis , Cardiomyopathies/genetics , Cardiomyopathies/metabolism , DNA Mutational Analysis , Electron Transport Complex III/genetics , Electron Transport Complex III/metabolism , Electrophysiologic Techniques, Cardiac , Female , Humans , Infant, Newborn , ran GTP-Binding Protein/metabolism
3.
Case Rep Pediatr ; 2012: 879161, 2012.
Article in English | MEDLINE | ID: mdl-23119213

ABSTRACT

Myocardial ischemia in pediatric population is uncommon and usually due to congenital heart disease or extracardiac conditions leading to poor coronary perfusion. A 6-day-old newborn presented with respiratory distress and signs of heart failure. ECG, echocardiography, and laboratory results were consistent with myocardial ischemia. Coronary angiography was performed to exclude anomalous origin of coronary arteries, showing normal coronary artery origin and course. Thrombophilia and extra-cardiac causes were ruled out. Clinical conditions improved with mechanical ventilation and diuretics, enzyme levels lowered, repolarisation and systolic function abnormalities regressed, but ischemic electrocardiographic and echocardiographic signs still presented during intense crying. Becaues of suspicion of microvascular angina, therapy with ASA and beta-blocker was started. At 5 month followup, the baby was in good clinical condition and no more episodes were recorded. We believe it is an interesting case, as no similar cases have been recorded till now.

4.
Pediatrics ; 125(6): e1448-52, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20478932

ABSTRACT

OBJECTIVE: The objective of this study was to evaluate the effects of breastfeeding on the risk for fever after routine immunizations. METHODS: A prospective cohort study was conducted at a pediatric vaccination center in Naples, Italy. The mothers of the infants scheduled to receive routine immunizations were instructed on how to measure and record infant temperature on the evening of the vaccination and for the subsequent 3 days. The information about the incidence of fever was obtained by telephone on the third day after vaccination. The relative risk for fever in relation to the type of breastfeeding was estimated in multivariate analyses that adjusted for vaccine dose, maternal education and smoking, and number of other children in the household. RESULTS: A total of 460 infants were recruited, and information on the outcome was obtained for 450 (98%). Fever was reported for 30 (25%), 48 (31%), and 94 (53%) of the infants who were being exclusively breastfed, partially breastfed, or not breastfed at all, respectively (P < .01). The relative risk for fever among infants who were exclusively and partially breastfed was 0.46 (95% confidence interval: 0.33-0.66) and 0.58 (95% confidence interval: 0.44-0.77), respectively. The protection conferred by breastfeeding persisted even when considering the role of several potential confounders. CONCLUSIONS: In this study, breastfeeding was associated with a decreased incidence of fever after immunizations.


Subject(s)
Breast Feeding , Fever/epidemiology , Immunization , Confounding Factors, Epidemiologic , Female , Humans , Infant , Male , Multivariate Analysis , Prospective Studies , Risk Assessment , Smoking/epidemiology
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