Observation of universal Hall response in strongly interacting Fermions.

The Hall effect, which originates from the motion of charged particles in magnetic fields, has deep consequences for the description of materials, extending far beyond condensed matter. Understanding such an effect in interacting systems represents a fundamental challenge, even for small magnetic fields. In this work, we used an atomic quantum simulator in which we tracked the motion of ultracold fermions in two-leg ribbons threaded by artificial magnetic fields. Through controllable quench dynamics, we measured the Hall response for a range of synthetic tunneling and atomic interaction strengths. We unveil a universal interaction-independent behavior above an interaction threshold, in agreement with theoretical analyses. The ability to reach hard-to-compute regimes demonstrates the power of quantum simulation to describe strongly correlated topological states of matter.

Observation of a Dipolar Quantum Gas with Metastable Supersolid Properties.

The competition of dipole-dipole and contact interactions leads to exciting new physics in dipolar gases, well illustrated by the recent observation of quantum droplets and rotons in dipolar condensates. We show that the combination of the roton instability and quantum stabilization leads under proper conditions to a novel regime that presents supersolid properties due to the coexistence of stripe modulation and phase coherence. In a combined experimental and theoretical analysis, we determine the parameter regime for the formation of coherent stripes, whose lifetime of a few tens of milliseconds is limited by the eventual destruction of the stripe pattern due to three-body losses. Our results open intriguing prospects for the development of long-lived dipolar supersolids.

Synthetic Dimensions and Spin-Orbit Coupling with an Optical Clock Transition.

We demonstrate a novel way of synthesizing spin-orbit interactions in ultracold quantum gases, based on a single-photon optical clock transition coupling two long-lived electronic states of two-electron ^{173}Yb atoms. By mapping the electronic states onto effective sites along a synthetic "electronic" dimension, we have engineered fermionic ladders with synthetic magnetic flux in an experimental configuration that has allowed us to achieve uniform fluxes on a lattice with minimal requirements and unprecedented tunability. We have detected the spin-orbit coupling with fiber-link-enhanced clock spectroscopy and directly measured the emergence of chiral edge currents, probing them as a function of the flux. These results open new directions for the investigation of topological states of matter with ultracold atomic gases.

Observation of chiral edge states with neutral fermions in synthetic Hall ribbons.

Chiral edge states are a hallmark of quantum Hall physics. In electronic systems, they appear as a macroscopic consequence of the cyclotron orbits induced by a magnetic field, which are naturally truncated at the physical boundary of the sample. Here we report on the experimental realization of chiral edge states in a ribbon geometry with an ultracold gas of neutral fermions subjected to an artificial gauge field. By imaging individual sites along a synthetic dimension, encoded in the nuclear spin of the atoms, we detect the existence of the edge states and observe the edge-cyclotron orbits induced during quench dynamics. The realization of fermionic chiral edge states opens the door for edge state interferometry and the study of non-Abelian anyons in atomic systems.

A compact ultranarrow high-power laser system for experiments with 578 nm ytterbium clock transition.

In this paper, we present the realization of a compact, high-power laser system able to excite the ytterbium clock transition at 578 nm. Starting from an external-cavity laser based on a quantum dot chip at 1156 nm with an intra-cavity electro-optic modulator, we were able to obtain up to 60 mW of visible light at 578 nm via frequency doubling. The laser is locked with a 500 kHz bandwidth to an ultra-low-expansion glass cavity stabilized at its zero coefficient of thermal expansion temperature through an original thermal insulation and correction system. This laser allowed the observation of the clock transition in fermionic (173)Yb with a <50 Hz linewidth over 5 min, limited only by a residual frequency drift of some 0.1 Hz/s.

Strongly Interacting Gas of Two-Electron Fermions at an Orbital Feshbach Resonance.

We report on the experimental observation of a strongly interacting gas of ultracold two-electron fermions with an orbital degree of freedom and magnetically tunable interactions. This realization has been enabled by the demonstration of a novel kind of Feshbach resonance occurring in the scattering of two (173)Yb atoms in different nuclear and electronic states. The strongly interacting regime at resonance is evidenced by the observation of anisotropic hydrodynamic expansion of the two-orbital Fermi gas. These results pave the way towards the realization of new quantum states of matter with strongly correlated fermions with an orbital degree of freedom.

Direct observation of coherent interorbital spin-exchange dynamics.

We report on the first direct observation of fast spin-exchange coherent oscillations between different long-lived electronic orbitals of ultracold 173Yb fermions. We measure, in a model-independent way, the strength of the exchange interaction driving this coherent process. This observation allows us to retrieve important information on the interorbital collisional properties of 173Yb atoms and paves the way to novel quantum simulations of paradigmatic models of two-orbital quantum magnetism.

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists.

Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) from dying cells. HMGB1 is a nuclear nonhistone chromatin-binding protein. It is secreted at the late stages of cellular demise and engages Toll-like receptor4 (TLR4) on dendritic cells (DCs) to accelerate the processing of phagocytic cargo in the DC and to facilitate antigen presentation by DC to T cells. The absence of HMGB1 expression by dying tumor cells exposed to anthracyclines or oxaliplatin compromises DC-dependent T-cell priming by tumor-associated antigens. Here, we show that transplantable tumors exhibiting weak expression of nuclear HMGB1 respond to chemotherapy more effectively if the treatment is combined with the local or systemic administration of a highly purified and physiochemically defined and standardized lipopolysaccharide solution, which acts as a high-potency and exclusive TLR4 agonist, called Dendrophilin (DEN). The synergistic antitumor effects mediated by the combination of chemotherapy and immunotherapy relied upon the presence of the MyD88 (myeloid differentiation primary response gene) adapter of TLR4 (but not that of the TIR-domain-containing adapter-inducing interferon-ß adapter), in line with the well-characterized action of DEN on the MyD88 signaling pathway. DEN and anthracyclines synergized to induce intratumoral accumulation of interferon-γ-producing CD4(+) and CD8(+) T lymphocytes. Moreover, DEN could restore the immunogenicity of dying tumor cells from which HMGB1 had been depleted by RNA interference. These findings underscore the potential clinical utility of combination regimens involving immunogenic chemotherapy and certain TLR4 agonists in advanced HMGB1-deficient cancers.

Coherent addition of laser beams in resonant passive optical cavities.

An optical resonator, designed for frequency doubling of cw single-frequency radiation, is simultaneously injected by two phase-coherent laser beams with the same frequency. By using standard methods in laser-cavity stabilization, we are able to stabilize the cavity length on resonance with the laser, as well as the relative phase of the fundamental beams, to fulfill the optimum coupling conditions simultaneously on the two input couplers. By using this method, we generate reliably more than 220 mW of single-frequency radiation at 399 nm using two 0.5 W semiconductor tapered amplifiers at 798 nm. This method can be generalized to a larger number of input couplers and holds promise for improving the performances of extreme-UV frequency combs.

Scattering in mixed dimensions with ultracold gases.

We experimentally investigate the mix-dimensional scattering occurring when the collisional partners live in different dimensions. We employ a binary mixture of ultracold atoms and exploit a species-selective 1D optical lattice to confine only one atomic species in 2D. By applying an external magnetic field in proximity of a Feshbach resonance, we adjust the free-space scattering length to observe a series of resonances in mixed dimensions. By monitoring 3-body inelastic losses, we measure the magnetic field values corresponding to the mix-dimensional scattering resonances and find a good agreement with the theoretical predictions based on simple energy considerations.

Entropy exchange in a mixture of ultracold atoms.

We investigate experimentally the entropy transfer between two distinguishable atomic quantum gases at ultralow temperatures. Exploiting a species-selective trapping potential, we are able to control the entropy of one target gas in presence of a second auxiliary gas. With this method, we drive the target gas into the degenerate regime in conditions of controlled temperature by transferring entropy to the auxiliary gas. We envision that our method could be useful both to achieve the low entropies required to realize new quantum phases and to measure the temperature of atoms in deep optical lattices. We verified the thermalization of the two species in a 1D lattice.

Observation of heteronuclear atomic Efimov resonances.

Building on the recent experimental observation with ultracold atoms, we report the first experimental evidence of Efimov physics in a heteronuclear system. A mixture of ;{41}K and ;{87}Rb atoms was cooled to few hundred nanokelvins and stored in an optical dipole trap. Exploiting a broad interspecies Feshbach resonance, the losses due to three-body collisions were studied as a function of the interspecies scattering length. We observe an enhancement of the three-body collisions for three distinct values of the interspecies scattering lengths, both positive and negative, where no Feshbach resonances are expected. We attribute the two features at negative scattering length to the existence of two kinds of Efimov trimers, KKRb and KRbRb.

Double species Bose-Einstein condensate with tunable interspecies interactions.

We produce Bose-Einstein condensates of two different species, 87Rb and 41K, in an optical dipole trap in proximity of interspecies Feshbach resonances. We discover and characterize two Feshbach resonances, located around 35 and 79 G, by observing the three-body losses and the elastic cross section. The narrower resonance is exploited to create a double species condensate with tunable interactions. Our system opens the way to the exploration of double species Mott insulators and, more in general, of the quantum phase diagram of the two-species Bose-Hubbard model.

39K Bose-Einstein condensate with tunable interactions.

We produce a Bose-Einstein condensate of 39K atoms. Condensation of this species with a naturally small and negative scattering length is achieved by a combination of sympathetic cooling with 87Rb and direct evaporation, exploiting the magnetic tuning of both inter- and intraspecies interactions at Feshbach resonances. We explore the tunability of the self-interactions by studying the expansion and the stability of the condensate. We find that a 39K condensate is interesting for future experiments requiring a weakly-interacting Bose gas.

Optically induced lensing effect on a Bose-Einstein condensate expanding in a moving lattice.

We report the experimental observation of a lensing effect on a Bose-Einstein condensate expanding in a moving 1D optical lattice. The effect of the periodic potential can be described by an effective mass dependent on the condensate quasimomentum. By changing the velocity of the atoms in the frame of the optical lattice, we induce a focusing of the condensate along the lattice direction. The experimental results are compared with the numerical predictions of an effective 1D theoretical model. In addition, a precise band spectroscopy of the system is carried out by looking at the real-space propagation of the atomic wave packet in the optical lattice.