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4.
Intern Med ; 47(6): 511-3, 2008.
Article in English | MEDLINE | ID: mdl-18344637

ABSTRACT

We present a case of scleroderma complicated by severe pulmonary hypertension. The use of a three-drug (bosentan, iloprost, and sildenafil) approach contributed to significant improvement of both the clinical conditions and the pulmonary hemodynamics. Combining three pulmonary vasodilators with different mechanisms of action could benefit patients with severe pulmonary hypertension resistant to conventional therapy.


Subject(s)
Hypertension, Pulmonary/drug therapy , Hypertension, Pulmonary/etiology , Iloprost/therapeutic use , Piperazines/therapeutic use , Scleroderma, Systemic/complications , Sulfonamides/therapeutic use , Sulfones/therapeutic use , Vasodilator Agents/therapeutic use , Bosentan , Drug Therapy, Combination , Electrocardiography , Female , Humans , Hypertension, Pulmonary/physiopathology , Middle Aged , Purines/therapeutic use , Sildenafil Citrate , Treatment Outcome
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