[Crystaline mineral deposits on copper intrauterine devices. Study involving diffraction by X-rays on whole IUDs]. / Depots mineraux cristallises sur les dispositifs intra-uterins au cuivre. Etude par diffraction de rayons X sur les DIU entiers.

PIP: The crystallized mineral deposits on 91 copper IUDs removed by normal procedures were analyzed using x-ray diffraction. 50 Nova-T, 27 Multiload 375, and 14 Gravigard devices were divided into a group of 32 in place for 10-36 months and a group of 59 in place for over 36 months. Studies were performed by x-ray diffraction on whole IUDs in the fresh or dry state and by using classic x-ray, infrared, and atomic absorption spectrometry methods on deposits. Coils of all the IUDs were covered with a layer of cuprous oxide adherent to the metal that flaked over time. Crystals or coatings formed white deposits on 63% of all IUDs, especially when cuprous oxide adhered to the metal. The deposits covered 65-85% of adherent oxides and only 33-38% of flaked oxides for the 1st and 2nd durations of use respectively. Deposits were more abundant on Nova T and Gravigard than on Multiload devices. For the short and long periods of use, the respective frequencies were 67 and 74% on Nova Ts, 25 and 47% on Multiloads, and 88 and 67% on Gravigard. Calcium carbonate (CaCO3) was the only crystalline inorganic compound found, and was present with or without white deposit on 80% of IUDs. It was in the form of calcite, accompanied by vaterite in 40% of cases and rarely by aragonite. Calcium was substituted by magnesium, with an average of 3.7 atoms. Sodium, potassium, and excess magnesium were not in the organic crystalline phase.^ieng

[The effects of different inhibitors on bronchoconstriction induced by leukotriene D4 in isolated and perfused guinea pig lung]. / Effects de différents inhibiteurs sur la bronchoconstriction induite par le leucotriène D4 au niveau du poumon isolé et perfusé de cobaye.

The effects of selective inhibitions of both cyclo-oxygenase and lipoxygenase pathways were studied in the isolated, perfused and ventilated guinea-pig lungs. Leukotriene D4 (0.3 nmol) induced a significant bronchoconstriction. This effect was significantly inhibited by IPL 55712 (a SRS-A antagonist) and by Imidazole or Dazoxiben (specific thromboxane synthetase inhibitors), but aspirin and indomethacin were without significant effect on this broncho-constriction. Our results suggest that the principal component of leukotriene D4 induced bronchoconstriction in guinea-pig lungs is primary.

[Effects of verapamil and propranolol on bronchoconstriction induced by leukotriene D4 in the isolated perfused guinea pig lung]. / Effets du vérapamil et du propranolol sur la bronchoconstriction induite par le leucotriène D4 au niveau du poumon isolé et perfusé de cobaye.

The effects of verapamil and propranolol on the LTD4-induced bronchoconstriction were studied in the isolated, perfused and ventilated guinea pig lungs. Verapamil (4.10(-5) et 1, 2.10(-4)M.1(-1], a calcium antagonist, produces a significative inhibition of LTD4-induced bronchoconstriction. On the other hand, propranolol (10(-7)M and 10(-4)M) does not increase the constrictor effects of LTD4 in guinea-pig isolated lung. These first results obtained in guinea-pig lung, confirmed the protective effect of verapamil, effect previously demonstrated in vivo or in vitro by using lung parenchymal strips. We have also confirmed the difference between the in vivo and in vitro effects of propranolol.

[The effects of different inhibitors on the bronchoconstriction induced by leukotriene D4 in the isolated and perfused guinea pig lung]. / Effets de différents inhibiteurs sur la bronchoconstriction induite par le leucotriène D4 au niveau du poumon isolé et perfusé de cobaye.

The effects of selective inhibitors of both cyclo-oxygenase and lipoxygenase pathways were studied in the isolated, perfused and ventilated guinea-pig lungs. Leukotriene D4 (0,3 nmol) induced a significant bronchoconstriction. This effect was significantly inhibited by FPL 55712 (a SRS-A antagonist) and by Imidazole or Dazoxiben (specific thromboxane synthetase inhibitors), but aspirin and indomethacin were without significant effect on this bronchoconstriction. Our results suggests that the principal component of leukotriene D4 induced bronchoconstriction in guinea-pig lungs is primary.

[Effect of an MAO inhibitor, phenelzine, on acetylation of isoniazid by isolated perfused rat liver]. / Influence d'un IMAO, la phénelzine, sur l'acétylation de l'isoniazide par le foie isolé perfusé de rat.

Phenelzin, a monoamine oxydase inhibitor, administered in vivo, in rats, slowed down the initial velocity of isoniazid acetylation in isolated perfused liver. After in vitro addition in perfusion medium phenelzin decreased as well the initial velocity of acetylation as the total amount of acetylated substrate.

[Experimental value of the biliary excretion of the conjugated form of SBP by the in vivo liver and by the isolated and perfused liver]. / Intérêt expérimental de l'élimination biliaire de la forme conjuguée de la BSP par le foie, in vivo et par le foie isolé et perfusé

We first studied the uptake and excretion of the dye BSP by the isolated and perfused rat liver and by the rat liver in vivo. We then studied BSP-glutathion conjugation with these same methods. We found that benziodarone which induces a marked decrease of conjugation is able to inhibit in vitro the combination BSP-glutathion.