[Atrial lead placement in the right atrial appendage during recent or chronic arrhythmia]. / Implantation de la sonde atriale dans l'auricule droit chez des patients en arythmie atriale récente ou chronique en vue d'une régularisation différée du rythme. Performance de la sonde à 6 mois.

An atrial arrhythmia could be encountered during the atrial lead implantation. The lead placement must subsequently be delayed after restitution of the sinus rhythm or completely abandoned. The authors investigate the atrial lead placement during atrial arrhythmia and the lead performance at 6-month follow-up. The study population was 65 patients aged 78.5 years, 42 males and 28 structural heart diseases. They were implanted for sick sinus syndrome (n=14), atrioventricular block (n=44), infra-hisian conduction abnormality (n=7) in association with an atrial fibrillation (63.1%), an atrial flutter (24.6%) or an atrial tachycardia (12.3%). The onset of the arrhythmia was < or = 7 days (47.7%) or > 7 days (52.3%). An atrial lead was placed in the right atrial appendage under fluoroscopic control. If the sinus rhythm was not restored at 1 month, an electrical cardioversion was performed. The per-implantation atrial signal amplitude was 2.2+/-1.5 mV (range 0.5 mV to 7 mV). Sinus rhythm was restored in 54 patients. At 1 month, one patient was in an incessant atrial fibrillation. The 53 patients in sinus rhythm had a good atrial lead performance. Out of 46 patients who completed the 6-month follow-up, 4 had an arrhythmia recurrence. The 42 patients in sinus rhythm had a good atrial lead performance. At 1 and 6-month follow-up, the atrial pacing threshold (1.1+/-0.7 V vs 1.2+/-1.0 V, ns) and the atrial signal amplitude (2.1+/-1.0 mV and 2.1+/-0.9 mV, ns) were stable. Comparing the patients with a recent or a chronic arrhythmia, the pacing thresholds (1.2+/-1.1 V vs 1.14+/-0.8 V, ns), the atrial signal amplitudes (2.17+/-0.9 mV vs 2.05+/-0.9 mV, ns) and the proportion of satisfactory pacemaker performance in DDD(R) mode for the patients in sinus rhythm (100% vs 100%, ns) did not statistically differ between the two groups at 6 months. In conclusion, the placement of an atrial lead in the right atrial appendage during an atrial arrhythmia is feasible with a good lead performance at 6 months in sinus rhythm regardless the onset time of the arrhythmia and provides a satisfactory atrial-based pacing with the preservation of the atrioventricular synchrony.

[Retraining in dento-facial orthopedics. An orthodontist's viewpoint]. / La rééducation en orthopédie dento-faciale. Point de vue d'un orthodontiste.

In dentofacial orthopedics, rehabilitation concerns the performance of the orofacial functions. Orthodontists will therefore speak of rehabilitation of functions, or functional therapy. Orofacial functions seem to obey a hierarchical system in accordance with their physiological importance; the impact of their disorders on both muscular behavior and facial morphogenesis, proportionally to their physiological importance. Therefore, priority will be given at a very early stage to the rehabilitation of respiration: restoring nasal ventilation is indeed an essential condition to obtain balanced oral functions because oral ventilation conditions both muscular posture and the performance of other functions. A little later, affective immaturity symptoms closely linked to various persisting bad suction habits will be looked after. At last, the rehabilitation of phonation and chewing both affected by the previous dysfunctions will participate in acquiring correct lingual position. The age for intervention will before all depend on the dysfunctional etiopathogeny. The morphological context, the importance of the malocclusion, and some orthodontic appliances also play a role in the the dysfunctional requests and the alterations of oral behavior.

The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT).

The evaluation of the electrostatic molecular potential at important nucleophilic sites of the purine and pyrimidine bases in poly (dG.dC) and poly (dA.dT) and of the evolution of the potential through the series free bases-nucleosides-nucleotides-single polynucleotide helices-double helices enables the interpretation of the evolution of the corresponding reactivity of the bases towards a series of electrophilic carcinogenic and mutagenic reactants.